Search Results - "Brakhage, A"

Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus by Shekhova, Elena, Kniemeyer, Olaf, Brakhage, Axel A

“…Drug resistance in fungal pathogens is of incredible importance to global health, yet the mechanisms of drug action remain only loosely defined. Antifungal…”
Get full text

Regulation and Role of Fungal Secondary Metabolites by Macheleidt, Juliane, Mattern, Derek J, Fischer, Juliane, Netzker, Tina, Weber, Jakob, Schroeckh, Volker, Valiante, Vito, Brakhage, Axel A

“…Fungi have the capability to produce a tremendous number of so-called secondary metabolites, which possess a multitude of functions, e.g., communication…”
Get full text

The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence by Valiante, Vito, Macheleidt, Juliane, Föge, Martin, Brakhage, Axel A

“…Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe infections with invasive growth in immunocompromised patients. The fungal…”
Get full text

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters by Netzker, Tina, Fischer, Juliane, Weber, Jakob, Mattern, Derek J, König, Claudia C, Valiante, Vito, Schroeckh, Volker, Brakhage, Axel A

“…Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in…”
Get full text

Human and plant fungal pathogens: the role of secondary metabolites by Scharf, Daniel H, Heinekamp, Thorsten, Brakhage, Axel A

“…  [...]melanin-deficient M. oryzae mutants produce non-pigmented appressoria that are unable to penetrate epidermal cells of the leaf cuticle [9]. Fungal SM…”
Get full text

Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA by Bruns, Sandra, Kniemeyer, Olaf, Hasenberg, Mike, Aimanianda, Vishukumar, Nietzsche, Sandor, Thywissen, Andreas, Jeron, Andreas, Latgé, Jean-Paul, Brakhage, Axel A, Gunzer, Matthias

“…Aspergillus fumigatus is the most important airborne fungal pathogen causing life-threatening infections in immunocompromised patients. Macrophages and…”
Get full text

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex by Gsaller, Fabio, Hortschansky, Peter, Furukawa, Takanori, Carr, Paul D, Rash, Bharat, Capilla, Javier, Müller, Christoph, Bracher, Franz, Bowyer, Paul, Haas, Hubertus, Brakhage, Axel A, Bromley, Michael J

“…Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs,…”
Get full text

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity by Akoumianaki, Tonia, Kyrmizi, Irene, Valsecchi, Isabel, Gresnigt, Mark S., Samonis, George, Drakos, Elias, Boumpas, Dimitrios, Muszkieta, Laetitia, Prevost, Marie-Christine, Kontoyiannis, Dimitrios P., Chavakis, Triantafyllos, Netea, Mihai G., van de Veerdonk, Frank L., Brakhage, Axel A., El-Benna, Jamel, Beauvais, Anne, Latge, Jean-Paul, Chamilos, Georgios

“…Concealing pathogen-associated molecular patterns (PAMPs) is a principal strategy used by fungi to avoid immune recognition. Surface exposure of PAMPs during…”
Get full text

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans by Schroeckh, Volker, Scherlach, Kirstin, Nützmann, Hans-Wilhelm, Shelest, Ekaterina, Schmidt-Heck, Wolfgang, Schuemann, Julia, Martin, Karin, Hertweck, Christian, Brakhage, Axel A

“…Fungi produce numerous low molecular weight molecules endowed with a multitude of biological activities. However, mining the full-genome sequences of fungi…”
Get full text

Conidial surface proteins at the interface of fungal infections by Blango, Matthew G, Kniemeyer, Olaf, Brakhage, Axel A

“…Another important protein on the surface of A. fumigatus conidia is the Mep1p metalloprotease, which is released from spores in the mammalian lung to cleave…”
Get full text

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation by Nützmann, Hans-Wilhelm, Reyes-Dominguez, Yazmid, Scherlach, Kirstin, Schroeckh, Volker, Horn, Fabian, Gacek, Agnieszka, Schümann, Julia, Hertweck, Christian, Strauss, Joseph, Brakhage, Axel A

“…Sequence analyses of fungal genomes have revealed that the potential of fungi to produce secondary metabolites is greatly underestimated. In fact, most gene…”
Get full text

Microbial interactions trigger the production of antibiotics by Netzker, Tina, Flak, Michal, Krespach, Mario KC, Stroe, Maria C, Weber, Jakob, Schroeckh, Volker, Brakhage, Axel A

“…[Display omitted] Since the discovery of penicillin, antibiotics have been instrumental in treating infectious diseases. However, emerging antibiotic…”
Get full text

HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus by Schrettl, Markus, Beckmann, Nicola, Varga, John, Heinekamp, Thorsten, Jacobsen, Ilse D, Jöchl, Christoph, Moussa, Tarek A, Wang, Shaohua, Gsaller, Fabio, Blatzer, Michael, Werner, Ernst R, Niermann, William C, Brakhage, Axel A, Haas, Hubertus

“…Iron is essential for a wide range of cellular processes. Here we show that the bZIP-type regulator HapX is indispensable for the transcriptional remodeling…”
Get full text

Surface hydrophobin prevents immune recognition of airborne fungal spores by Aimanianda, Vishukumar, Bayry, Jagadeesh, Bozza, Silvia, Kniemeyer, Olaf, Perruccio, Katia, Elluru, Sri Ramulu, Clavaud, Cécile, Paris, Sophie, Brakhage, Axel A., Kaveri, Srini V., Romani, Luigina, Latgé, Jean-Paul

“…Breathe easy: why inhaled fungal spores don't provoke an immune reaction Every day we inhale thousands of tiny fungal spores (conidia), originating from many…”
Get full text

Biosynthesis and function of gliotoxin in Aspergillus fumigatus by Scharf, Daniel H., Heinekamp, Thorsten, Remme, Nicole, Hortschansky, Peter, Brakhage, Axel A., Hertweck, Christian

“…Gliotoxin (GT) is the prototype of the epidithiodioxopiperazine (ETP)-type fungal toxins. GT plays a critical role in the pathobiology of Aspergillus fumigatus…”
Get full text

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus by Altwasser, Robert, Baldin, Clara, Weber, Jakob, Guthke, Reinhard, Kniemeyer, Olaf, Brakhage, Axel A, Linde, Jörg, Valiante, Vito

“…Mitogen activated protein kinases (MAPKs) are highly conserved in eukaryotic organisms. In pathogenic fungi, their activities were assigned to different…”
Get full text

Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome by Mirhakkak, Mohammad H., Chen, Xiuqiang, Ni, Yueqiong, Heinekamp, Thorsten, Sae-Ong, Tongta, Xu, Lin-Lin, Kurzai, Oliver, Barber, Amelia E., Brakhage, Axel A., Boutin, Sebastien, Schäuble, Sascha, Panagiotou, Gianni

“…Aspergillus fumigatus , an opportunistic human pathogen, frequently infects the lungs of people with cystic fibrosis and is one of the most common causes of…”
Get full text

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus by Jain, Radhika, Valiante, Vito, Remme, Nicole, Docimo, Teresa, Heinekamp, Thorsten, Hertweck, Christian, Gershenzon, Jonathan, Haas, Hubertus, Brakhage, Axel A.

“…Summary The saprophytic fungus Aspergillus fumigatus is the most important air‐borne fungal pathogen. The cell wall of A. fumigatus has been studied…”
Get full text

Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin by Stroe, Maria Cristina, Netzker, Tina, Scherlach, Kirstin, Krüger, Thomas, Hertweck, Christian, Valiante, Vito, Brakhage, Axel A

“…Microorganisms produce numerous secondary metabolites (SMs) with various biological activities. Many of their encoding gene clusters are silent under standard…”
Get full text

Dynamic optimization reveals alveolar epithelial cells as key mediators of host defense in invasive aspergillosis by Ewald, Jan, Rivieccio, Flora, Radosa, Lukáš, Schuster, Stefan, Brakhage, Axel A, Kaleta, Christoph

“…Aspergillus fumigatus is an important human fungal pathogen and its conidia are constantly inhaled by humans. In immunocompromised individuals, conidia can…”
Get full text