Search Results - "Brakenhielm, Ebba"

Microvascular and lymphatic dysfunction in HFpEF and its associated comorbidities by Cuijpers, Ilona, Simmonds, Steven J., van Bilsen, Marc, Czarnowska, Elżbieta, González Miqueo, Arantxa, Heymans, Stephane, Kuhn, Annika R., Mulder, Paul, Ratajska, Anna, Jones, Elizabeth A. V., Brakenhielm, Ebba

“…Heart failure with preserved ejection fraction (HFpEF) is a complex heterogeneous disease for which our pathophysiological understanding is still limited and…”
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Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction by Henri, Orianne, Pouehe, Chris, Houssari, Mahmoud, Galas, Ludovic, Nicol, Lionel, Edwards-Lévy, Florence, Henry, Jean-Paul, Dumesnil, Anais, Boukhalfa, Inès, Banquet, Sébastien, Schapman, Damien, Thuillez, Christian, Richard, Vincent, Mulder, Paul, Brakenhielm, Ebba

“…BACKGROUND—The lymphatic system regulates interstitial tissue fluid balance, and lymphatic malfunction causes edema. The heart has an extensive lymphatic…”
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Therapeutic vascular growth in the heart by Brakenhielm, Ebba, Richard, Vincent

“…Despite tremendous efforts in preclinical research over the last decades, the clinical translation of therapeutic angiogenesis to grow stable and functional…”
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Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis by Brakenhielm, Ebba, González, Arantxa, Díez, Javier

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Lymphatic and Immune Cell Cross-Talk Regulates Cardiac Recovery After Experimental Myocardial Infarction by Houssari, Mahmoud, Dumesnil, Anais, Tardif, Virginie, Kivelä, Riikka, Pizzinat, Nathalie, Boukhalfa, Ines, Godefroy, David, Schapman, Damien, Hemanthakumar, Karthik A., Bizou, Mathilde, Henry, Jean-Paul, Renet, Sylvanie, Riou, Gaetan, Rondeaux, Julie, Anouar, Youssef, Adriouch, Sahil, Fraineau, Sylvain, Alitalo, Kari, Richard, Vincent, Mulder, Paul, Brakenhielm, Ebba

“…OBJECTIVE:Lymphatics play an essential pathophysiological role in promoting fluid and immune cell tissue clearance. Conversely, immune cells may influence…”
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Does anti-VEGF bevacizumab improve survival in experimental sepsis? by Besnier, Emmanuel, Brakenhielm, Ebba, Richard, Vincent, Tamion, Fabienne

“…See related research by Jeong et al. https://ccforum.biomedcentral.com/articles/10.1186/cc12742 This comment refers to the article available at:…”
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Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI by Rondeaux, Julie, Groussard, Déborah, Renet, Sylvanie, Tardif, Virginie, Dumesnil, Anaïs, Chu, Alphonse, Di Maria, Léa, Lemarcis, Théo, Valet, Manon, Henry, Jean-Paul, Badji, Zina, Vézier, Claire, Béziau-Gasnier, Delphine, Neele, Annette E., de Winther, Menno P. J., Guerrot, Dominique, Brand, Marjorie, Richard, Vincent, Durand, Eric, Brakenhielm, Ebba, Fraineau, Sylvain

“…Epigenetic regulation of histone H3K27 methylation has recently emerged as a key step during alternative immunoregulatory M2-like macrophage polarization;…”
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Enhanced angiogenesis and increased cardiac perfusion after myocardial infarction in protein tyrosine phosphatase 1B‐deficient mice by Besnier, Marie, Galaup, Ariane, Nicol, Lionel, Henry, Jean‐Paul, Coquerel, David, Gueret, Alexandre, Mulder, Paul, Brakenhielm, Ebba, Thuillez, Christian, Germain, Stéphane, Richard, Vincent, Ouvrard‐Pascaud, Antoine

“…The protein tyrosine phosphatase 1B (PTP1B) modulates tyrosine kinase receptors, among which is the vascular endothelial growth factor receptor type 2…”
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Suppression of Prostate Cancer Nodal and Systemic Metastasis by Blockade of the Lymphangiogenic Axis by BURTON, Jeremy B, PRICEMAN, Saul J, SUNG, James L, BRAKENHIELM, Ebba, DONG SUNG AN, PYTOWSKI, Bronislaw, ALITALO, Kari, WU, Lily

“…Lymph node involvement denotes a poor outcome for patients with prostate cancer. Our group, along with others, has shown that initial tumor cell dissemination…”
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Role of M2-like macrophage recruitment during angiogenic growth factor therapy by Barbay, Virginie, Houssari, Mahmoud, Mekki, Malik, Banquet, Sebastien, Edwards-Lévy, Florence, Henry, Jean-Paul, Dumesnil, Anais, Adriouch, Sahil, Thuillez, Christian, Richard, Vincent, Brakenhielm, Ebba

“…Therapeutic angiogenesis has yet to fulfill its promise for the clinical treatment of ischemic diseases. Given the impact of macrophages during…”
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Leptin Induces Vascular Permeability and Synergistically Stimulates Angiogenesis with FGF-2 and VEGF by Cao, Renhai, Brakenhielm, Ebba, Wahlestedt, Claes, Thyberg, Johan, Cao, Yihai

“…Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood…”
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Arteriogenic Therapy by Intramyocardial Sustained Delivery of a Novel Growth Factor Combination Prevents Chronic Heart Failure by BANQUET, Sebastien, GOMEZ, Elodie, YIHAI CAO, THUILLEZ, Christian, MULDER, Paul, RICHARD, Vincent, BRAKENHIELM, Ebba, NICOL, Lionel, EDWARDS-LEVY, Florence, HENRY, Jean-Paul, CAO, Renhai, SCHAPMAN, Damien, DAUTREAUX, Brigitte, LALLEMAND, Francoise, BAUER, Fabrice

“…Therapeutic angiogenesis is a promising approach for the treatment of cardiovascular diseases, including myocardial infarction and chronic heart failure. We…”
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Sphingolipid Signaling Takes Center Stage in Regulation of Lymphatic–Immune Crosstalk in Lymphedema by Brakenhielm, Ebba

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Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis by BJÖRNDAHL, Meit A, RENHAI CAO, BURTON, Jeremy B, BRAKENHIELM, Ebba, RELIGA, Piotr, GALTER, Dagmar, WU, Lily, YIHAI CAO

“…Metastases are commonly found in the lymphatic system. The molecular mechanism of lymphatic metastasis is, however, poorly understood. Here we report that…”
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Heart Rate Reduction Induced by the If Current Inhibitor Ivabradine Improves Diastolic Function and Attenuates Cardiac Tissue Hypoxia by Fang, Yuehua, Debunne, Manuelle, Vercauteren, Magali, Brakenhielm, Ebba, Richard, Vincent, Lallemand, Francoise, Henry, Jean-Paul, Mulder, Paul, Thuillez, Christian

“…AIMSEnhanced heart rate (HR) is a compensatory mechanism in chronic heart failure (CHF), preserving cardiac output, but at the cost of increased left…”
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Cardiac lymphatics in health and disease by Brakenhielm, Ebba, Alitalo, Kari

“…The lymphatic vasculature, which accompanies the blood vasculature in most organs, is indispensable in the maintenance of tissue fluid homeostasis, immune cell…”
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Transient heart rate reduction improves acute decompensated heart failure‐induced left ventricular and coronary dysfunction by Peschanski, Nicolas, Harouki, Najah, Soulie, Matthieu, Lachaux, Marianne, Nicol, Lionel, Remy‐Jouet, Isabelle, Henry, Jean‐Paul, Dumesnil, Anais, Renet, Sylvanie, Fougerousse, Françoise, Brakenhielm, Ebba, Ouvrard‐Pascaud, Antoine, Thuillez, Christian, Richard, Vincent, Roussel, Jérôme, Mulder, Paul

“…Aims Acute decompensated heart failure (ADHF), a live‐threatening complication of heart failure (HF), associates a further decrease of the already by…”
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Progenitor Cell Mobilizing Treatments Prevent Experimental Transplant Arteriosclerosis by Roux, Nicolas, M.D, Brakenhielm, Ebba, M.D., Ph.D, Freguin-Bouillant, Caroline, M.D., Ph.D, Lallemand, Françoise, Henry, Jean-Paul, Boyer, Olivier, M.D., Ph.D, Thuillez, Christian, M.D., Ph.D, Plissonnier, Didier, M.D., Ph.D

“…Objective Vascular rejection after organ transplantation is characterized by an arterial occlusive lesion, resulting from intimal proliferation occurring in…”
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Cardiac Lymphangiogenesis in CVDs by Brakenhielm, Ebba, Sultan, Ibrahim, Alitalo, Kari

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Role of Cardiac Lymphatics in Myocardial Edema and Fibrosis: JACC Review Topic of the Week by Brakenhielm, Ebba, González, Arantxa, Díez, Javier

“…The cardiac lymphatic network plays a key role in regulation of myocardial extracellular volume and immune cell homeostasis. In different pathological…”
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