Search Results - "Brainson, Christine F"

BRG1 Loss Predisposes Lung Cancers to Replicative Stress and ATR Dependency by Gupta, Manav, Concepcion, Carla P, Fahey, Caroline G, Keshishian, Hasmik, Bhutkar, Arjun, Brainson, Christine F, Sanchez-Rivera, Francisco J, Pessina, Patrizia, Kim, Jonathan Y, Simoneau, Antoine, Paschini, Margherita, Beytagh, Mary C, Stanclift, Caroline R, Schenone, Monica, Mani, D R, Li, Chendi, Oh, Audris, Li, Fei, Hu, Hai, Karatza, Angeliki, Bronson, Roderick T, Shaw, Alice T, Hata, Aaron N, Wong, Kwok-Kin, Zou, Lee, Carr, Steven A, Jacks, Tyler, Kim, Carla F

“…Inactivation of SMARCA4/BRG1, the core ATPase subunit of mammalian SWI/SNF complexes, occurs at very high frequencies in non-small cell lung cancers (NSCLC)…”
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Cellular Origins of EGFR‐Driven Lung Cancer Cells Determine Sensitivity to Therapy by Chen, Fan, Liu, Jinpeng, Flight, Robert M., Naughton, Kassandra J., Lukyanchuk, Alexsandr, Edgin, Abigail R., Song, Xiulong, Zhang, Haikuo, Wong, Kwok‐Kin, Moseley, Hunter N. B., Wang, Chi, Brainson, Christine F.

“…Targeting the epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKIs) is one of the major precision medicine treatment options for lung…”
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EZH2 inhibition confers PIK3CA-driven lung tumors enhanced sensitivity to PI3K inhibition by Chen, Fan, Liu, Jinpeng, Song, Xiulong, DuCote, Tanner J., Byrd, Aria L., Wang, Chi, Brainson, Christine F.

“…Members of the PI3K signaling pathway, especially PIK3CA, the gene encoding the catalytic subunit of the PI3K complex, are highly mutated and amplified in…”
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L858R / L718Q and L858R / L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds by Imam, Ibrahim A., Al Adawi, Shatha, Liu, Xiaoqi, Ellingson, Sally, Brainson, Christine F., Moseley, Hunter N. B., Zinner, Ralph, Zhang, Shulin, Shao, Qing

“…ABSTRACT Acquired resistance to first‐line treatments in various cancers both promotes cancer recurrence as well as limits effective treatment. This is true…”
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Therapeutic potential of tumor-infiltrating lymphocytes in non-small cell lung cancer by Plaugher, Daniel R., Childress, Avery R., Gosser, Christian M., Esoe, Dave-Preston, Naughton, Kassandra J., Hao, Zhonglin, Brainson, Christine F.

“…Lung cancer is the leading cause of cancer-related death worldwide, with poor outcomes even for those diagnosed at early stages. Current standard-of-care for…”
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Metabolic reprogramming driven by EZH2 inhibition depends on cell–matrix interactions by W-M Fan, Teresa, Islam, Jahid M.M., Higashi, Richard M., Lin, Penghui, Brainson, Christine F., Lane, Andrew N.

“…EZH2 (Enhancer of Zeste Homolog 2), a subunit of Polycomb Repressive Complex 2 (PRC2), catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3),…”
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Using Artificial Intelligence to Identify Tumor Microenvironment Heterogeneity in Non–Small Cell Lung Cancers by DuCote, Tanner J., Naughton, Kassandra J., Skaggs, Erika M., Bocklage, Therese J., Allison, Derek B., Brainson, Christine F.

“…Lung cancer heterogeneity is a major barrier to effective treatments and encompasses not only the malignant epithelial cell phenotypes and genetics but also…”
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The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET by Kong, Yifan, Allison, Derek B, Zhang, Qiongsi, He, Daheng, Li, Yuntong, Mao, Fengyi, Li, Chaohao, Li, Zhiguo, Zhang, Yanquan, Wang, Jianlin, Wang, Chi, Brainson, Christine F, Liu, Xiaoqi

“…Increased abundance of polo-like kinase 1 (PLK1) is observed in various tumor types, particularly in lung adenocarcinoma (LUAD). Here, we found that PLK1…”
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Brain glycogen serves as a critical glucosamine cache required for protein glycosylation by Sun, Ramon C., Young, Lyndsay E.A., Bruntz, Ronald C., Markussen, Kia H., Zhou, Zhengqiu, Conroy, Lindsey R., Hawkinson, Tara R., Clarke, Harrison A., Stanback, Alexandra E., Macedo, Jessica K.A., Emanuelle, Shane, Brewer, M. Kathryn, Rondon, Alberto L., Mestas, Annette, Sanders, William C., Mahalingan, Krishna K., Tang, Buyun, Chikwana, Vimbai M., Segvich, Dyann M., Contreras, Christopher J., Allenger, Elizabeth J., Brainson, Christine F., Johnson, Lance A., Taylor, Richard E., Armstrong, Dustin D., Shaffer, Robert, Waechter, Charles J., Vander Kooi, Craig W., DePaoli-Roach, Anna A., Roach, Peter J., Hurley, Thomas D., Drake, Richard R., Gentry, Matthew S.

“…Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In…”
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Aberrant glycogen accumulation alters gene expression and promotes lung tumor progression in vivo by Lamb, Jessica F., Conroy, Lindsey R., James, Alexis N., Buoncristiani, Michael D., Relich, Eric R., Brainson, Christine F., Sun, Ramon C.

“…Lung cancer is one of the most prevalent cancers worldwide, accounting for nearly two million new cases each year. Lung adenocarcinoma (LUAD) is the most…”
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Isolation, Culture, and Phenotypic Analysis of Murine Lung Organoids by Evans, Kelly, Dabrowska, Catherine, Ng, Minn E, Brainson, Christine F, Lee, Joo-Hyeon

“…Three-dimensional (3D) organoid cultures retain self-renewing stem cells that differentiate into multiple cell types that display spatial organization and…”
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Using 3-Dimensional Cultures to Propagate Genetically Modified Lung Organoids by Chen, Fan, Naughton, Kassandra J, Lee, Joo-Hyeon, Brainson, Christine F

“…Transformed lung organoids have extensive applications in lung cancer modeling and drug screening. Traditional two-dimensional (2D) cultures fail to propagate…”
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The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations by Agrawal, Pankaj B, Wang, Ruobing, Li, Hongmei Lisa, Schmitz-Abe, Klaus, Simone-Roach, Chantelle, Chen, Jingxin, Shi, Jiahai, Louie, Tin, Sheng, Shaohu, Towne, Meghan C, Brainson, Christine F, Matthay, Michael A, Kim, Carla F, Bamshad, Michael, Emond, Mary J, Gerard, Norma P, Kleyman, Thomas R, Gerard, Craig

“…Cystic fibrosis (CF) remains the most lethal genetic disease in the Caucasian population. However, there is great variability in clinical phenotypes and…”
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Description of a Lung Cancer Hotspot: Disparities in Lung Cancer Histology, Incidence, and Survival in Kentucky and Appalachian Kentucky by Brainson, Christine F., Huang, Bin, Chen, Quan, McLouth, Laurie E., He, Chunyan, Hao, Zhonglin, Arnold, Susanne M., Zinner, Ralph G., Mullett, Timothy W., Bocklage, Therese J., Orren, David K., Villano, John L., Durbin, Eric B.

“…•Kentucky has significantly higher proportions of small cell and squamous cell carcinomas•Appalachian females have 3.5-fold higher incidence rates of small…”
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EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas by DuCote, Tanner J, Song, Xiulong, Naughton, Kassandra J, Chen, Fan, Plaugher, Daniel R, Childress, Avery R, Gellert, Abigail R, Skaggs, Erika M, Qu, Xufeng, Liu, Jinze, Liu, Jinpeng, Li, Fei, Wong, Kwok-Kin, Brainson, Christine F

“…Two important factors that contribute to resistance to immune checkpoint inhibitors (ICI) are an immune-suppressive microenvironment and limited antigen…”
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Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition by Burikhanov, Ravshan, Ganguly, Saptadwipa, Ellingson, Sally, Sviripa, Vitaliy M, Araujo, Nathalia, Li, Shunqiang, Venkatraman, Prasanna, Rao, Mahadev, Choughule, Anuradha, Brainson, Christine F, Zhan, Chang-Guo, Spielmann, H Peter, Watt, David S, Govindan, Ramaswamy, Rangnekar, Vivek M

“…Lung cancer is the leading cause of cancer-related deaths. Lung cancer cells develop resistance to apoptosis by suppressing the secretion of the tumor…”
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Abstract 5189: Activity of polycomb repressive complex 2 determines sensitivity to epigenetic therapy by Chen, Fan, Brainson, Christine F.

“…Abstract EZH2 is a histone methyltransferase that tri-methylates histone H3 at lysine 27 (H3K27me) in the context of the Polycomb Repressive Complex 2, and is…”
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Abstract 5185: Squamous cell cancers and chronic obstructive pulmonary disease share polycomb repressive cComplex 2 dysregulation by Byrd, Aria L., Brainson, Christine F.

“…Abstract Non-small cell lung cancers often share the aberrant differentiation patterns observed in the bronchiolar epithelium of chronic obstructive pulmonary…”
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Abstract 2819: Mass spectrometry imaging reveals heterogeneous glycogen metabolism in non small cell lung cancer by Conroy, Lindsey R., Young, Lyndsay EA, Clarke, Harrison A., Stanback, Alexandra E., Buoncristiani, Michael D., Brainson, Christine F., Allison, Derek B., Sun, Ramon C., Drake, Richard R.

“…Abstract Lung cancer is the leading cause of cancer related death worldwide, with a high mortality rate even when diagnosed at an early stage. Identifying the…”
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Metabolic reprogramming driven by EZH2 inhibition depends on cell-matrix interactions by W-M Fan, Teresa, Islam, Jahid M M, Higashi, Richard M, Lin, Penghui, Brainson, Christine F, Lane, Andrew N

“…EZH2 (Enhancer of Zeste Homolog 2), a subunit of Polycomb Repressive Complex 2 (PRC2), catalyzes the trimethylation of histone H3 at lysine 27 (H3K27me3),…”
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