Search Results - "Braine, Emma L."

Effects of the T-type calcium channel CaV3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models by Casillas-Espinosa, Pablo M., Lin, Runxuan, Li, Rui, Nandakumar, Nanditha M., Dawson, Georgia, Braine, Emma L., Martin, Benoît, Powell, Kim L., O'Brien, Terence J.

“…Low-voltage-activated or T-type Ca2+ channels play a key role in the generation of seizures in absence epilepsy. We have described a homozygous, gain of…”
Get full text

Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy by Casillas-Espinosa, Pablo M, Anderson, Alison, Harutyunyan, Anna, Li, Crystal, Lee, Jiyoon, Braine, Emma L, Brady, Rhys D, Sun, Mujun, Huang, Cheng, Barlow, Christopher K, Shah, Anup D, Schittenhelm, Ralf B, Mychasiuk, Richelle, Jones, Nigel C, Shultz, Sandy R, O'Brien, Terence J

“…There are no pharmacological disease-modifying treatments with an enduring effect to mitigate the seizures and comorbidities of established chronic temporal…”
Get full text

Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy by Powell, Kim L., Liu, Zining, Curl, Claire L., Raaijmakers, Antonia J.A., Sharma, Pragati, Braine, Emma L., Gomes, Flavia M., Sivathamboo, Shobi, Macefield, Vaughan G., Casillas-Espinosa, Pablo M., Jones, Nigel C., Delbridge, Lea M., O’Brien, Terence J.

“…This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic…”
Get full text

Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development by Cook, Andrew D, Pobjoy, Jarrad, Steidl, Stefan, Dürr, Manuela, Braine, Emma L, Turner, Amanda L, Lacey, Derek C, Hamilton, John A

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to be important in the development of inflammatory models of rheumatoid arthritis and…”
Get full text

Regulation of systemic and local myeloid cell subpopulations by bone marrow cell–derived granulocyte–macrophage colony‐stimulating factor in experimental inflammatory arthritis by Cook, Andrew D., Turner, Amanda L., Braine, Emma L., Pobjoy, Jarrad, Lenzo, Jason C., Hamilton, John A.

“…Objective Even though there are clinical trials assessing granulocyte–macrophage colony‐stimulating factor (GM‐CSF) blockade in rheumatoid arthritis (RA),…”
Get full text

The Phenotype of Inflammatory Macrophages Is Stimulus Dependent: Implications for the Nature of the Inflammatory Response by Cook, Andrew D, Braine, Emma L, Hamilton, John A

“…Many diseases are characterized by inflammatory reactions involving both the innate and adaptive arms of the immune system. Thioglycolate medium (TM) injection…”
Get full text

Stimulus-Dependent Requirement for Granulocyte-Macrophage Colony-Stimulating Factor in Inflammation by Cook, Andrew D, Braine, Emma L, Hamilton, John A

“…Data from several inflammation/autoimmunity models indicate that GM-CSF can be a key inflammatory mediator. Convenient models in readily accessible tissues are…”
Get full text

Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease by Cook, A D, Braine, E L, Campbell, I K, Rich, M J, Hamilton, J A

“…There is mounting evidence for a role of the growth factor granulocyte-macrophage colony-stimulating factor (GM-CSF) in inflammatory disease, including…”
Get full text

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy by Casillas-Espinosa, Pablo M, Shultz, Sandy R, Braine, Emma L, Jones, Nigel C, Snutch, Terrance P, Powell, Kim L, O'Brien, Terence J

“…We evaluated whether pharmacologically targeting T-type Ca channels with Z944, a potent and selective antagonist, has disease-modifying effects in a model of…”
Get full text

Tau Phosphorylation Patterns in the Rat Cerebral Cortex After Traumatic Brain Injury and Sodium Selenate Effects: An Epibios4rx Project 2 Study by Grandizoli Saletti, Patricia, Casillas-Espinosa, Pablo M, Panagiotis Lisgaras, Christos, Bi Mowrey, Wenzhu, Li, Qianyun, Liu, Wei, Brady, Rhys D, Ali, Idrish, Silva, Juliana, Yamakawa, Glenn, Hudson, Matt, Li, Crystal, Braine, Emma L, Coles, Lisa, Cloyd, James C, Jones, Nigel C, Shultz, Sandy R, Moshé, Solomon L, O'Brien, Terence J, Galanopoulou, Aristea S

“…Sodium selenate (SS) activates protein phosphatase 2 (PP2A) and reduces phosphorylated tau (pTAU) and late post-traumatic seizures after lateral fluid…”
Get more information

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis by Ndode-Ekane, Xavier Ekolle, Santana-Gomez, Cesar, Casillas-Espinosa, Pablo M., Ali, Idrish, Brady, Rhys D., Smith, Gregory, Andrade, Pedro, Immonen, Riikka, Puhakka, Noora, Hudson, Matthew R., Braine, Emma L., Shultz, Sandy R., Staba, Richard J., O’Brien, Terence J., Pitkänen, Asla

“…•All experimental sites: UEF, Melbourne and UCLA, produced TBI rats with moderate to severe injury.•Variability in mortality between the experimental sites was…”
Get full text

ComBating inter‐site differences in field strength: harmonizing preclinical traumatic brain injury MRI data by Quach, Mara, Ali, Idrish, Shultz, Sandy R., Casillas‐Espinosa, Pablo M., Hudson, Matthew R., Jones, Nigel C., Silva, Juliana C., Yamakawa, Glenn R., Braine, Emma L., Immonen, Riikka, Staba, Richard J., Tohka, Jussi, Harris, Neil G., Gröhn, Olli, O'Brien, Terence J., Wright, David K.

“…Integrating datasets from multiple sites and scanners can increase statistical power for neuroimaging studies but can also introduce significant inter‐site…”
Get full text

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis by Casillas-Espinosa, Pablo M., Andrade, Pedro, Santana-Gomez, Cesar, Paananen, Tomi, Smith, Gregory, Ali, Idrish, Ciszek, Robert, Ndode-Ekane, Xavier Ekolle, Brady, Rhys D., Tohka, Jussi, Hudson, Matthew R., Perucca, Piero, Braine, Emma L., Immonen, Riikka, Puhakka, Noora, Shultz, Sandy R., Jones, Nigel C., Staba, Richard J., Pitkänen, Asla, O’Brien, Terence J.

“…•We harmonized the surgical and data collection procedures, equipment and data analysis for chronic EEG recording in order to phenotype PTE in this rat model…”
Get full text

Image data harmonization tools for the analysis of post-traumatic epilepsy development in preclinical multisite MRI studies by Bhagavatula, Sweta, Cabeen, Ryan, Harris, Neil G, Gröhn, Olli, Wright, David K, Garner, Rachael, Bennett, Alexis, Alba, Celina, Martinez, Aubrey, Ndode-Ekane, Xavier Ekolle, Andrade, Pedro, Paananen, Tomi, Ciszek, Robert, Immonen, Riikka, Manninen, Eppu, Puhakka, Noora, Tohka, Jussi, Heiskanen, Mette, Ali, Idrish, Shultz, Sandy R, Casillas-Espinosa, Pablo M, Yamakawa, Glenn R, Jones, Nigel C, Hudson, Matthew R, Silva, Juliana C, Braine, Emma L, Brady, Rhys D, Santana-Gomez, Cesar E, Smith, Gregory D, Staba, Richard, O'Brien, Terence J, Pitkänen, Asla, Duncan, Dominique

“…Preclinical MRI studies have been utilized for the discovery of biomarkers that predict post-traumatic epilepsy (PTE). However, these single site studies often…”
Get full text

The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation by Cook, Andrew D, Vlahos, Ross, Massa, Christine M, Braine, Emma L, Lenzo, Jason C, Turner, Amanda L, Way, Kerrie J, Hamilton, John A

“…There are two plasminogen activators (PAs), urokinase type-PA (u-PA) and tissue type-PA (t-PA). While u-PA is considered to be involved in cellular migration…”
Get more information

Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement by Cook, Andrew D, De Nardo, Christine M, Braine, Emma L, Turner, Amanda L, Vlahos, Ross, Way, Kerrie J, Beckman, S Kaye, Lenzo, Jason C, Hamilton, John A

“…Urokinase-type plasminogen activator (u-PA) has been implicated in fibrinolysis, cell migration, latent cytokine activation, cell activation, T-cell…”
Get full text

Differing Roles for Urokinase and Tissue-Type Plasminogen Activator in Collagen-Induced Arthritis by Cook, Andrew D., Braine, Emma L., Campbell, Ian K., Hamilton, John A.

“…The plasminogen activators, urokinase PA (u-PA) and tissue-type PA (t-PA), are believed to play important roles in inflammatory cell infiltration, fibrin…”
Get full text

Image Data Harmonization Tools for the Analysis of Posttraumatic Epilepsy Development in Preclinical Multisite MRI Studies by Bhagavatula, Sweta, Cabeen, Ryan, Harris, Neil G., Gröhn, Olli, Wright, David K., Garner, Rachael, Bennett, Alexis, Alba, Celina, Martinez, Aubrey, Ndode-Ekane, Xavier Ekolle, Andrade, Pedro, Paananen, Tomi, Ciszek, Robert, Immonen, Riikka, Manninen, Eppu, Puhakka, Noora, Tohka, Jussi, Heiskanen, Mette, Ali, Idrish, Shultz, Sandy R., Casillas-Espinosa, Pablo M., Yamakawa, Glenn R., Jones, Nigel C., Hudson, Matthew R., Silva, Juliana C., Braine, Emma L., Brady, Rhys D., Santana-Gomez, Cesar E., Smith, Gregory D., Staba, Rick, O’Brien, Terence J, Pitkänen, Asla, Duncan, Dominique

“…Preclinical MRI studies have been utilized for the discovery of biomarkers that predict posttraumatic epilepsy (PTE). However, these single site studies often…”
Get full text

Effects of the T-type calcium channel Ca V 3.2 R1584P mutation on absence seizure susceptibility in GAERS and NEC congenic rats models by Casillas-Espinosa, Pablo M, Lin, Runxuan, Li, Rui, Nandakumar, Nanditha M, Dawson, Georgia, Braine, Emma L, Martin, Benoît, Powell, Kim L, O'Brien, Terence J

“…Low-voltage-activated or T-type Ca channels play a key role in the generation of seizures in absence epilepsy. We have described a homozygous, gain of function…”
Get full text

Harmonization of lateral fluid-percussion injury model production and postinjury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis by Ndode-Ekane, Xavier Ekolle, Santana-Gomez, Cesar, Casillas-Espinosa, Pablo M., Ali, Idrish, Brady, Rhys D., Smith, Gregory, Andrade, Pedro, Immonen, Riikka, Puhakka, Noora, Hudson, Matthew R., Braine, Emma L., Shultz, Sandy R., Staba, Richard J., O’Brien, Terence J., Pitkänen, Asla

“…Multi-center preclinical studies can facilitate the discovery of biomarkers of antiepileptogenesis and thus facilitate the diagnosis and treatment development…”
Get full text