Search Results - "Brain Bank, The Netherlands"

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    Perivascular phosphorylated TDP-43 inclusions are associated with Alzheimer's disease pathology and loss of CD146 and Aquaporin-4 by Santiago, Jessica, Pocevičiūtė, Dovilė, Wennström, Malin

    Published in Brain pathology (Zurich, Switzerland) (09-09-2024)
    “…The majority of patients with Alzheimer's disease (AD) exhibit aggregates of Trans-active response DNA binding protein 43 (TDP-43) in their hippocampus, which…”
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    Journal Article
  3. 3

    Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels by Wennström, Malin, Janelidze, Shorena, Nilsson, K Peter R, Serrano, Geidy E, Beach, Thomas G, Dage, Jeffrey L, Hansson, Oskar

    Published in Acta neuropathologica communications (06-01-2022)
    “…Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in…”
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    Increased plasma and brain immunoglobulin A in Alzheimer's disease is lost in apolipoprotein E ε4 carriers by Pocevičiūtė, Dovilė, Nuñez-Diaz, Cristina, Roth, Bodil, Janelidze, Shorena, Giannisis, Andreas, Hansson, Oskar, Wennström, Malin

    Published in Alzheimer's research & therapy (26-08-2022)
    “…Alzheimer's disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation,…”
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    Plasma IAPP-Autoantibody Levels in Alzheimer's Disease Patients Are Affected by APOE4 Status by Pocevičiūtė, Dovilė, Roth, Bodil, Schultz, Nina, Nuñez-Diaz, Cristina, Janelidze, Shorena, The Netherlands Brain Bank, Olofsson, Anders, Hansson, Oskar, Wennström, Malin

    “…Pancreas-derived islet amyloid polypeptide (IAPP) crosses the blood-brain barrier and co-deposits with amyloid beta (Aβ) in brains of type 2 diabetes (T2D) and…”
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    The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and App NL−F/NL−F mice by Nuñez-Diaz, Cristina, Andersson, Emelie, Schultz, Nina, Pocevičiūtė, Dovilė, Hansson, Oskar, Nilsson, K. Peter R., Wennström, Malin

    Published in Alzheimer's research & therapy (2024)
    “…Background: Amyloid beta (Aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of Alzheimer’s disease (AD) patients…”
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  7. 7

    Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide by Nuñez-Diaz, Cristina, Pocevičiūtė, Dovilė, Schultz, Nina, Welinder, Charlotte, Swärd, Karl, Wennström, Malin

    Published in Molecular brain (15-02-2023)
    “…The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2…”
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  8. 8

    Interplay between androgen and CXCR4 chemokine signaling in myelin repair by Asbelaoui, Narimène, Abi-Ghanem, Charly, Schlecht-Louf, Géraldine, Oukil, Hania, Schumacher, Michael, Ghoumari, Abdel Mouman

    Published in Acta neuropathologica communications (30-01-2024)
    “…In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling demyelinating…”
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    The Relationship between p-tau217, p-tau231, and p-tau205 in the Human Brain Is Affected by the Cellular Environment and Alzheimer's Disease Pathology by Wennström, Malin, Schultz, Nina, Gallardo, Paula Mille, The Netherlands Brain Bank, Serrano, Geidy E, Beach, Thomas G, Bose, Suchira, Hansson, Oskar

    Published in Cells (Basel, Switzerland) (01-02-2024)
    “…The levels of p-tau217 and p-tau231 in cerebrospinal fluid (CSF) are associated with early amyloid beta (Aß) changes in the brain, while the CSF levels of…”
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    Alpha-amylase 1A copy number variants and the association with memory performance and Alzheimer's dementia by Byman, Elin, Nägga, Katarina, Gustavsson, Anna-Märta, Andersson-Assarsson, Johanna, Hansson, Oskar, Sonestedt, Emily, Wennström, Malin

    Published in Alzheimer's research & therapy (21-11-2020)
    “…Previous studies have shown that copy number variation (CNV) in the alpha (α)-amylase gene (AMY1A) is associated with body mass index, insulin resistance, and…”
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  11. 11

    Movement disorders are linked to TDP-43 burden in the substantia nigra of FTLD-TDP brain donors by Fiondella, Luigi, Gami-Patel, Priya, Blok, Christian A, Rozemuller, Annemieke J M, Hoozemans, Jeroen J M, Pijnenburg, Yolande A L, Scarioni, Marta, Dijkstra, Anke A

    Published in Acta neuropathologica communications (12-04-2023)
    “…Movement disorders (MD) have been linked to degeneration of the substantia nigra (SN) in Parkinson's disease and include bradykinesia, rigidity, and tremor…”
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