Search Results - "Brain"

Neurotransmitter modulation by the gut microbiota by Strandwitz, Philip

“…[Display omitted] •The human microbiota has been linked to numerous components of health and disease.•Gut bacteria can influence diseases of the enteric and…”
Get full text

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings by Paterson, Ross W, Brown, Rachel L, Benjamin, Laura, Nortley, Ross, Wiethoff, Sarah, Bharucha, Tehmina, Jayaseelan, Dipa L, Kumar, Guru, Raftopoulos, Rhian E, Zambreanu, Laura, Vivekanandam, Vinojini, Khoo, Anthony, Geraldes, Ruth, Chinthapalli, Krishna, Boyd, Elena, Tuzlali, Hatice, Price, Gary, Christofi, Gerry, Morrow, Jasper, McNamara, Patricia, McLoughlin, Benjamin, Lim, Soon Tjin, Mehta, Puja R, Levee, Viva, Keddie, Stephen, Yong, Wisdom, Trip, S Anand, Foulkes, Alexander J M, Hotton, Gary, Miller, Thomas D, Everitt, Alex D, Carswell, Christopher, Davies, Nicholas W S, Yoong, Michael, Attwell, David, Sreedharan, Jemeen, Silber, Eli, Schott, Jonathan M, Chandratheva, Arvind, Perry, Richard J, Simister, Robert, Checkley, Anna, Longley, Nicky, Farmer, Simon F, Carletti, Francesco, Houlihan, Catherine, Thom, Maria, Lunn, Michael P, Spillane, Jennifer, Howard, Robin, Vincent, Angela, Werring, David J, Hoskote, Chandrashekar, Jäger, Hans Rolf, Manji, Hadi, Zandi, Michael S

“…Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and…”
Get full text

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report by Nelson, Peter T, Dickson, Dennis W, Trojanowski, John Q, Jack, Clifford R, Boyle, Patricia A, Arfanakis, Konstantinos, Rademakers, Rosa, Alafuzoff, Irina, Attems, Johannes, Brayne, Carol, Coyle-Gilchrist, Ian T S, Chui, Helena C, Fardo, David W, Flanagan, Margaret E, Halliday, Glenda, Hokkanen, Suvi R K, Hunter, Sally, Jicha, Gregory A, Katsumata, Yuriko, Kawas, Claudia H, Keene, C Dirk, Kovacs, Gabor G, Kukull, Walter A, Levey, Allan I, Makkinejad, Nazanin, Montine, Thomas J, Murayama, Shigeo, Murray, Melissa E, Nag, Sukriti, Rissman, Robert A, Seeley, William W, Sperling, Reisa A, White, 3rd, Charles L, Yu, Lei, Schneider, Julie A

“…We describe a recently recognized disease entity, limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE neuropathological change (LATE-NC) is…”
Get full text

The cholinergic system in the pathophysiology and treatment of Alzheimer's disease by Hampel, Harald, Mesulam, M.-Marsel, Cuello, A Claudio, Farlow, Martin R, Giacobini, Ezio, Grossberg, George T, Khachaturian, Ara S, Vergallo, Andrea, Cavedo, Enrica, Snyder, Peter J, Khachaturian, Zaven S

“…Hampel et al. review the role of the cholinergic system in cognition and how cholinergic deficits in Alzheimer's disease interact with other aspects of disease…”
Get full text

Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study by Horsager, Jacob, Andersen, Katrine B, Knudsen, Karoline, Skjærbæk, Casper, Fedorova, Tatyana D, Okkels, Niels, Schaeffer, Eva, Bonkat, Sarah K, Geday, Jacob, Otto, Marit, Sommerauer, Michael, Danielsen, Erik H, Bech, Einar, Kraft, Jonas, Munk, Ole L, Hansen, Sandra D, Pavese, Nicola, Göder, Robert, Brooks, David J, Berg, Daniela, Borghammer, Per

“…Parkinson's disease is characterized by the presence of abnormal, intraneuronal α-synuclein aggregates, which may propagate from cell-to-cell in a prion-like…”
Get full text

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study by Postuma, Ronald B, Iranzo, Alex, Hu, Michele, Högl, Birgit, Boeve, Bradley F, Manni, Raffaele, Oertel, Wolfgang H, Arnulf, Isabelle, Ferini-Strambi, Luigi, Puligheddu, Monica, Antelmi, Elena, Cochen De Cock, Valerie, Arnaldi, Dario, Mollenhauer, Brit, Videnovic, Aleksandar, Sonka, Karel, Jung, Ki-Young, Kunz, Dieter, Dauvilliers, Yves, Provini, Federica, Lewis, Simon J, Buskova, Jitka, Pavlova, Milena, Heidbreder, Anna, Montplaisir, Jacques Y, Santamaria, Joan, Barber, Thomas R, Stefani, Ambra, St.Louis, Erik K, Terzaghi, Michele, Janzen, Annette, Leu-Semenescu, Smandra, Plazzi, Guiseppe, Nobili, Flavio, Sixel-Doering, Friederike, Dusek, Petr, Bes, Frederik, Cortelli, Pietro, Ehgoetz Martens, Kaylena, Gagnon, Jean-Francois, Gaig, Carles, Zucconi, Marco, Trenkwalder, Claudia, Gan-Or, Ziv, Lo, Christine, Rolinski, Michal, Mahlknecht, Philip, Holzknecht, Evi, Boeve, Angel R, Teigen, Luke N, Toscano, Gianpaolo, Mayer, Geert, Morbelli, Silvia, Dawson, Benjamin, Pelletier, Amelie

“…See Morris and Weil (doi:10.1093/brain/awz014) for a scientific commentary on this article. In a prospective multicentre study involving 1280 patients with…”
Get full text

COVID-19 neuropathology at Columbia University Irving Medical Center/New York Presbyterian Hospital by Thakur, Kiran T, Miller, Emily Happy, Glendinning, Michael D, Al-Dalahmah, Osama, Banu, Matei A, Boehme, Amelia K, Boubour, Alexandra L, Bruce, Samuel S, Chong, Alexander M, Claassen, Jan, Faust, Phyllis L, Hargus, Gunnar, Hickman, Richard A, Jambawalikar, Sachin, Khandji, Alexander G, Kim, Carla Y, Klein, Robyn S, Lignelli-Dipple, Angela, Lin, Chun-Chieh, Liu, Yang, Miller, Michael L, Moonis, Gul, Nordvig, Anna S, Overdevest, Jonathan B, Prust, Morgan L, Przedborski, Serge, Roth, William H, Soung, Allison, Tanji, Kurenai, Teich, Andrew F, Agalliu, Dritan, Uhlemann, Anne-Catrin, Goldman, James E, Canoll, Peter

“…Many patients with SARS-CoV-2 infection develop neurological signs and symptoms, though, to date, little evidence exists that primary infection of the brain is…”
Get full text

Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19 by Hosp, Jonas A, Dressing, Andrea, Blazhenets, Ganna, Bormann, Tobias, Rau, Alexander, Schwabenland, Marius, Thurow, Johannes, Wagner, Dirk, Waller, Cornelius, Niesen, Wolf D, Frings, Lars, Urbach, Horst, Prinz, Marco, Weiller, Cornelius, Schroeter, Nils, Meyer, Philipp T

“…During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, neurological symptoms increasingly moved into the focus of interest. In this…”
Get full text

How patients with multiple sclerosis acquire disability by Lublin, Fred D, Häring, Dieter A, Ganjgahi, Habib, Ocampo, Alex, Hatami, Farhad, Čuklina, Jelena, Aarden, Piet, Dahlke, Frank, Arnold, Douglas L, Wiendl, Heinz, Chitnis, Tanuja, Nichols, Thomas E, Kieseier, Bernd C, Bermel, Robert A

“…Patients with multiple sclerosis acquire disability either through: (1) Relapse-associated worsening (RAW), or (2) progression independent of relapse activity…”
Get full text

Impaired glymphatic function and clearance of tau in an Alzheimer's disease model by Harrison, Ian F, Ismail, Ozama, Machhada, Asif, Colgan, Niall, Ohene, Yolanda, Nahavandi, Payam, Ahmed, Zeshan, Fisher, Alice, Meftah, Soraya, Murray, Tracey K, Ottersen, Ole P, Nagelhus, Erlend A, O'Neill, Michael J, Wells, Jack A, Lythgoe, Mark F

“…The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein…”
Get full text

Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease by Janelidze, Shorena, Bali, Divya, Ashton, Nicholas J, Barthélemy, Nicolas R, Vanbrabant, Jeroen, Stoops, Erik, Vanmechelen, Eugeen, He, Yingxin, Dolado, Anna Orduña, Triana-Baltzer, Gallen, Pontecorvo, Michael J, Zetterberg, Henrik, Kolb, Hartmuth, Vandijck, Manu, Blennow, Kaj, Bateman, Randall J, Hansson, Oskar

“…Abstract Plasma phospho-tau (p-tau) species have emerged as the most promising blood-based biomarkers of Alzheimer's disease. Here, we performed a head-to-head…”
Get full text

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state by Smajić, Semra, Prada-Medina, Cesar A, Landoulsi, Zied, Ghelfi, Jenny, Delcambre, Sylvie, Dietrich, Carola, Jarazo, Javier, Henck, Jana, Balachandran, Saranya, Pachchek, Sinthuja, Morris, Christopher M, Antony, Paul, Timmermann, Bernd, Sauer, Sascha, Pereira, Sandro L, Schwamborn, Jens C, May, Patrick, Grünewald, Anne, Spielmann, Malte

“…Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic neurons, but the exact disease aetiology remains largely unknown. To…”
Get full text

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease by Pereira, Joana B, Janelidze, Shorena, Smith, Ruben, Mattsson-Carlgren, Niklas, Palmqvist, Sebastian, Teunissen, Charlotte E, Zetterberg, Henrik, Stomrud, Erik, Ashton, Nicholas J, Blennow, Kaj, Hansson, Oskar

“…Although recent clinical trials targeting amyloid-β in Alzheimer's disease have shown promising results, there is increasing evidence suggesting that…”
Get full text

Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease by Guo, Min, Wang, Jian, Zhao, Yanxin, Feng, Yiwei, Han, Sida, Dong, Qiang, Cui, Mei, Tieu, Kim

“…Accumulation of neuronal α-synuclein is a prominent feature in Parkinson's disease. More recently, such abnormal protein aggregation has been reported to…”
Get full text

Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome by Keddie, Stephen, Pakpoor, Julia, Mousele, Christina, Pipis, Menelaos, Machado, Pedro M, Foster, Mark, Record, Christopher J, Keh, Ryan Y S, Fehmi, Janev, Paterson, Ross W, Bharambe, Viraj, Clayton, Lisa M, Allen, Claire, Price, Olivia, Wall, Jasmine, Kiss-Csenki, Annamaria, Rathnasabapathi, Devi Priya, Geraldes, Ruth, Yermakova, Tatyana, King-Robson, Joshua, Zosmer, Maya, Rajakulendran, Sanjeev, Sumaria, Sheetal, Farmer, Simon F, Nortley, Ross, Marshall, Charles R, Newman, Edward J, Nirmalananthan, Niranjanan, Kumar, Guru, Pinto, Ashwin A, Holt, James, Lavin, Tim M, Brennan, Kathryn M, Zandi, Michael S, Jayaseelan, Dipa L, Pritchard, Jane, Hadden, Robert D M, Manji, Hadi, Willison, Hugh J, Rinaldi, Simon, Carr, Aisling S, Lunn, Michael P

“…Reports of Guillain-Barré syndrome (GBS) have emerged during the Coronavirus disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to…”
Get full text

Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks by Uddin, Lucina Q., Yeo, B. T. Thomas, Spreng, R. Nathan

“…The past decade has witnessed a proliferation of studies aimed at characterizing the human connectome. These projects map the brain regions comprising…”
Get full text

Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines by Filippi, Massimo, Preziosa, Paolo, Banwell, Brenda L, Barkhof, Frederik, Ciccarelli, Olga, De Stefano, Nicola, Geurts, Jeroen J G, Paul, Friedemann, Reich, Daniel S, Toosy, Ahmed T, Traboulsee, Anthony, Wattjes, Mike P, Yousry, Tarek A, Gass, Achim, Lubetzki, Catherine, Weinshenker, Brian G, Rocca, Maria A

“…MRI has improved the diagnostic work-up of multiple sclerosis, but inappropriate image interpretation and application of MRI diagnostic criteria contribute to…”
Get full text

Development and validation of an interpretable deep learning framework for Alzheimer's disease classification by Qiu, Shangran, Joshi, Prajakta S, Miller, Matthew I, Xue, Chonghua, Zhou, Xiao, Karjadi, Cody, Chang, Gary H, Joshi, Anant S, Dwyer, Brigid, Zhu, Shuhan, Kaku, Michelle, Zhou, Yan, Alderazi, Yazan J, Swaminathan, Arun, Kedar, Sachin, Saint-Hilaire, Marie-Helene, Auerbach, Sanford H, Yuan, Jing, Sartor, E Alton, Au, Rhoda, Kolachalama, Vijaya B

“…Alzheimer's disease is the primary cause of dementia worldwide, with an increasing morbidity burden that may outstrip diagnosis and management capacity as the…”
Get full text

Macrophage activation and its role in repair and pathology after spinal cord injury by Gensel, John C, Zhang, Bei

“…Abstract The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for…”
Get full text

Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort by Symonds, Joseph D, Zuberi, Sameer M, Stewart, Kirsty, McLellan, Ailsa, O'Regan, Mary, MacLeod, Stewart, Jollands, Alice, Joss, Shelagh, Kirkpatrick, Martin, Brunklaus, Andreas, Pilz, Daniela T, Shetty, Jay, Dorris, Liam, Abu-Arafeh, Ishaq, Andrew, Jamie, Brink, Philip, Callaghan, Mary, Cruden, Jamie, Diver, Louise A, Findlay, Christine, Gardiner, Sarah, Grattan, Rosemary, Lang, Bethan, MacDonnell, Jane, McKnight, Jean, Morrison, Calum A, Nairn, Lesley, Slean, Meghan M, Stephen, Elma, Webb, Alan, Vincent, Angela, Wilson, Margaret

“…Epilepsy is common in early childhood. In this age group it is associated with high rates of therapy-resistance, and with cognitive, motor, and behavioural…”
Get full text