Search Results - "Braga, Tárcio T"
-
1
Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic‐ and GPR109a‐mediated mechanisms
Published in The FASEB journal (01-11-2019)“…Butyrate is a short‐chain fatty acid derived from the metabolism of indigestible carbohydrates by the gut microbiota. Butyrate contributes to gut homeostasis,…”
Get full text
Journal Article -
2
Prophylactic Supplementation of Bifidobacterium longum 51A Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness
Published in Frontiers in microbiology (11-09-2017)“…Asthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms and severity in women change during menstruation…”
Get full text
Journal Article -
3
Administration of α-Galactosylceramide Improves Adenine-Induced Renal Injury
Published in Molecular medicine (Cambridge, Mass.) (18-06-2015)“…Natural killer T (NKT) cells are a subset of lymphocytes that reacts to glycolipids presented by CD1d. Invariant NKT cells (iNKT) correspond to >90% of the…”
Get full text
Journal Article -
4
Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis
Published in Kidney international (01-06-2011)“…Focal and segmental glomerulosclerosis (FSGS) is one of the most important causes of end-stage renal failure. The bradykinin B1 receptor has been associated…”
Get full text
Journal Article -
5
Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response
Published in Oncotarget (25-05-2018)“…The antitumor effect of metformin has been demonstrated in several types of cancer; however, the mechanisms involved are incompletely understood. In this…”
Get full text
Journal Article -
6
Caloric Restriction Promotes Structural and Metabolic Changes in the Skin
Published in Cell reports (Cambridge) (12-09-2017)“…Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR…”
Get full text
Journal Article -
7
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability
Published in Cell reports (Cambridge) (04-08-2015)“…The evolutionarily conserved miR-302 family of microRNAs is expressed during early mammalian embryonic development. Here, we report that deletion of miR-302a-d…”
Get full text
Journal Article -
8
Statins improve NASH via inhibition of RhoA and Ras
Published in American journal of physiology: Gastrointestinal and liver physiology (01-10-2016)“…Nonalcoholic steatohepatitis (NASH), especially as part of the metabolic syndrome (MS), is an increasing burden in Western countries. Statins are already used…”
Get more information
Journal Article -
9
Mesenchymal Stromal Cell-Derived Microvesicles Regulate an Internal Pro-Inflammatory Program in Activated Macrophages
Published in Frontiers in immunology (31-07-2017)“…Mesenchymal stromal cells (MSCs) are multipotent cells with abilities to exert immunosuppressive response promoting tissue repair. Studies have shown that MSCs…”
Get full text
Journal Article -
10
Palmitoleic acid reduces high fat diet-induced liver inflammation by promoting PPAR-γ-independent M2a polarization of myeloid cells
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01-10-2020)“…Palmitoleic acid (POA, 16:1n-7) is a lipokine that has potential nutraceutical use to treat non-alcoholic fatty liver disease. We tested the effects of POA…”
Get full text
Journal Article -
11
Detection of ASC Speck Formation by Flow Cytometry and Chemical Cross-linking
Published in Methods in molecular biology (Clifton, N.J.) (2018)“…Assembly of a relatively large protein aggregate or "speck" formed by the adaptor protein ASC is a common downstream step in the activation of most…”
Get more information
Journal Article -
12
Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration
Published in Molecular and cellular biochemistry (01-10-2016)“…Deficient wound healing is a common multifactorial complication in diabetic patients, but the cellular and molecular mechanisms involved are poorly defined. In…”
Get full text
Journal Article -
13
Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis
Published in Laboratory investigation (01-04-2014)“…Platelet-activating factor (PAF) is a lipid mediator with important pro-inflammatory effects, being synthesized by several cell types including kidney cells…”
Get full text
Journal Article -
14
Prophylactic Supplementation of Bifidobacterium longum 5 1A Protects Mice from Ovariectomy-Induced Exacerbated Allergic Airway Inflammation and Airway Hyperresponsiveness
Published in Frontiers in microbiology (2017)“…Asthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms and severity in women change during menstruation…”
Get full text
Journal Article