Analysis of SNAP25 mRNA expression and promoter DNA methylation in brain areas of Alzheimer’s Disease patients

Highlights ► Decrease in SNAP25 expression in brain areas of Alzheimer’s Disease in relation to elderly controls. ► SNAP25 mRNA expression alterations in brain might suggest an impairment in synaptic function. ► The changes in the auditory cortex reflected those in the hippocampus and the entorhinal...

Full description

Saved in:

Bibliographic Details
Published in:	Neuroscience Vol. 220; pp. 41 - 46
Main Authors:	Furuya, T.K, Silva, P.N.O, Payão, S.L.M, Bertolucci, P.H.F, Rasmussen, L.T, De Labio, R.W, Braga, I.L.S, Chen, E.S, Turecki, G, Mechawar, N, Mill, J, Smith, M.A.C
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 18-09-2012 Elsevier
Subjects:	Aged aging Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer’s Disease Biological and medical sciences Brain - metabolism DNA Methylation - genetics Female Fundamental and applied biological sciences. Psychology Humans Male Neurology post mortem brain tissue promoter DNA methylation Promoter Regions, Genetic - genetics Real-Time Polymerase Chain Reaction RNA, Messenger - analysis SNAP25 gene expression synaptic impairment Synaptosomal-Associated Protein 25 - biosynthesis Synaptosomal-Associated Protein 25 - genetics Synaptosomes - metabolism Transcriptome Vertebrates: nervous system and sense organs APP SNAP25 df DSM-IV base pair GLM synaptic impairment post mortem brain tissue CDR relative quantification promoter DNA methylation female SNAP25 gene expression β-amyloid AD MALDI-TOF cycle threshold qRT-PCR general linear model Polymerase Chain Reaction–Restriction Fragment Length Polymorphism C T apolipoprotein E Mini-Mental State Examination male RQ standard deviation Alzheimer’s Disease PCR–RFLP F PSEN2 PSEN1 M bp N βA SD NINCDS–ADRDA amyloid precursor protein MMSE APOE National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer’s Disease and Related Disorders Association degrees of freedom presenilin 2 presenilin 1 quantitative Reverse Transcription Polymerase Chain Reaction IV Diagnostic and Statistical Manual of Mental Disorders number of individuals clinical dementia rating synaptosomal-associated protein, 25 kDa aging matrix-assisted laser desorption ionization time of flight mass spectrometry CT Alzheimer's Disease
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights ► Decrease in SNAP25 expression in brain areas of Alzheimer’s Disease in relation to elderly controls. ► SNAP25 mRNA expression alterations in brain might suggest an impairment in synaptic function. ► The changes in the auditory cortex reflected those in the hippocampus and the entorhinal cortex. ► No Alzheimer’s Disease-associated differences in SNAP25 promoter DNA methylation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.06.035