Search Results - "Braeuning, Albert"

Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans? by Braeuning, Albert

“…The anticolvulsant phenobarbital (PB) and other activators of the constitutive androstane receptor (CAR) act as transient inducers of hepatocyte proliferation…”
Get full text

Activation of human nuclear receptors by perfluoroalkylated substances (PFAS) by Behr, Anne-Cathrin, Plinsch, Christin, Braeuning, Albert, Buhrke, Thorsten

“…Perfluoralkylated substances (PFAS) such as perfluorooctanoic acid (PFOA) or perfluorooctanesulfonic acid (PFOS) are used to produce, e.g., surface coatings…”
Get full text

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo by Stock, Valerie, Böhmert, Linda, Lisicki, Elisa, Block, Rafael, Cara-Carmona, Julia, Pack, Laura Kim, Selb, Regina, Lichtenstein, Dajana, Voss, Linn, Henderson, Colin J., Zabinsky, Elke, Sieg, Holger, Braeuning, Albert, Lampen, Alfonso

“…Evidence exists that humans are exposed to plastic microparticles via diet. Data on intestinal particle uptake and health-related effects resulting from…”
Get full text

Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro by Behr, Anne-Cathrin, Lichtenstein, Dajana, Braeuning, Albert, Lampen, Alfonso, Buhrke, Thorsten

“…•PFAS did not directly activate human ERα, ERβ and AR.•Some PFAS enhanced agonist-stimulated ERα, ERβ and AR activity.•PFAS did not stimulate proliferation of…”
Get full text

Cross-species analysis of hepatic cytochrome P450 and transport protein expression by Hammer, Helen, Schmidt, Felix, Marx-Stoelting, Philip, Pötz, Oliver, Braeuning, Albert

“…Most drugs and xenobiotics are metabolized in the liver. Amongst others, different cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of foreign…”
Get full text

Effects of okadaic acid, azaspiracid-1, yessotoxin and their binary mixtures on human intestinal Caco-2 cells by Alarcan, Jimmy, Braeuning, Albert

“…Phycotoxins are responsible for foodborne intoxications. Symptoms depend on the ingested toxins but mostly imply gastro-intestinal and neurological disorders…”
Get full text

Regulation of cytochrome P450 expression by Ras- and beta-catenin-dependent signaling by Braeuning, Albert

“…Signaling through the Ha-Ras/ mitogen-activated protein kinase cascade and through the Wnt/ beta-catenin signaling pathway has been implicated in various…”
Get more information

New approach methodologies in human regulatory toxicology – Not if, but how and when by Schmeisser, Sebastian, Miccoli, Andrea, von Bergen, Martin, Berggren, Elisabet, Braeuning, Albert, Busch, Wibke, Desaintes, Christian, Gourmelon, Anne, Grafström, Roland, Harrill, Joshua, Hartung, Thomas, Herzler, Matthias, Kass, George E.N., Kleinstreuer, Nicole, Leist, Marcel, Luijten, Mirjam, Marx-Stoelting, Philip, Poetz, Oliver, van Ravenzwaay, Bennard, Roggeband, Rob, Rogiers, Vera, Roth, Adrian, Sanders, Pascal, Thomas, Russell S., Marie Vinggaard, Anne, Vinken, Mathieu, van de Water, Bob, Luch, Andreas, Tralau, Tewes

“…The predominantly animal-centric approach of chemical safety assessment has increasingly come under pressure. Society is questioning overall performance,…”
Get full text

Pyrrolizidine Alkaloids Induce Cell Death in Human HepaRG Cells in a Structure-Dependent Manner by Glück, Josephin, Waizenegger, Julia, Braeuning, Albert, Hessel-Pras, Stefanie

“…Pyrrolizidine alkaloids (PAs) are a group of secondary metabolites produced in various plant species as a defense mechanism against herbivores. PAs consist of…”
Get full text

Comparative Analysis of Transcriptional Responses to Genotoxic and Non-Genotoxic Agents in the Blood Cell Model TK6 and the Liver Model HepaRG by Kreuzer, Katrin, Sprenger, Heike, Braeuning, Albert

“…Transcript signatures are a promising approach to identify and classify genotoxic and non-genotoxic compounds and are of interest as biomarkers or for future…”
Get full text

Is the question of phenobarbital as potential liver cancer risk factor for humans really resolved? by Braeuning, Albert, Schwarz, Michael

“…The mechanisms by which phenobarbital causes tumor promotion or inhibition are still not fully understood. Without such deeper mechanistic understanding,…”
Get full text

Pregnane X receptor mediates steatotic effects of propiconazole and tebuconazole in human liver cell lines by Knebel, Constanze, Buhrke, Thorsten, Süssmuth, Roderich, Lampen, Alfonso, Marx-Stoelting, Philip, Braeuning, Albert

“…Triazoles are commonly used fungicides which show liver toxicity in rodent studies. While hepatocellular hypertrophy is the most prominent finding, some…”
Get full text

Complex intestinal and hepatic in vitro barrier models reveal information on uptake and impact of micro-, submicro- and nanoplastics by Paul, Maxi B., Böhmert, Linda, Hsiao, I-Lun, Braeuning, Albert, Sieg, Holger

“…[Display omitted] Plastic particles are found almost ubiquitously in the environment and can get ingested orally by humans. We have used food-relevant…”
Get full text

The Connection of Azole Fungicides with Xeno-Sensing Nuclear Receptors, Drug Metabolism and Hepatotoxicity by Marx-Stoelting, Philip, Knebel, Constanze, Braeuning, Albert

“…Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole…”
Get full text

Regulation of expression of drug-metabolizing enzymes by oncogenic signaling pathways in liver tumors: a review by Braeuning, Albert, Schwarz, Michael

“…Mutations in genes encoding key players in oncogenic signaling pathways trigger specific downstream gene expression profiles in the respective tumor cell…”
Get full text

The presence of iron oxide nanoparticles in the food pigment E172 by Voss, Linn, Hsiao, I-Lun, Ebisch, Maximilian, Vidmar, Janja, Dreiack, Nadine, Böhmert, Linda, Stock, Valerie, Braeuning, Albert, Loeschner, Katrin, Laux, Peter, Thünemann, Andreas F., Lampen, Alfonso, Sieg, Holger

“…•In E172 pigments, nanoparticles were detectable by SAXS and TEM.•Nanoparticle number exceeded 50% for six of seven pigments.•Pigments are not toxic to human…”
Get full text

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification by Fritsche, Kristin, Ziková-Kloas, Andrea, Marx-Stoelting, Philip, Braeuning, Albert

“…The liver is the central metabolic organ of the body. The plethora of anabolic and catabolic pathways in the liver is tightly regulated by physiological…”
Get full text

Interplay of β-catenin with xenobiotic-sensing receptors and its role in glutathione S-transferase expression by Braeuning, Albert

“…The Wnt/β-catenin pathway plays an important role in liver homeostasis, as well as during prenatal liver development, liver regeneration, and…”
Get more information

Structure-Dependent Toxicokinetics of Selected Pyrrolizidine Alkaloids In Vitro by Buchmueller, Julia, Kaltner, Florian, Gottschalk, Christoph, Maares, Maria, Braeuning, Albert, Hessel-Pras, Stefanie

“…Phytochemicals like pyrrolizidine alkaloids (PAs) can affect the health of humans and animals. PAs can occur for example in tea, honey or herbs. Some PAs are…”
Get full text

Nanomaterials: certain aspects of application, risk assessment and risk communication by Laux, Peter, Tentschert, Jutta, Riebeling, Christian, Braeuning, Albert, Creutzenberg, Otto, Epp, Astrid, Fessard, Valérie, Haas, Karl-Heinz, Haase, Andrea, Hund-Rinke, Kerstin, Jakubowski, Norbert, Kearns, Peter, Lampen, Alfonso, Rauscher, Hubert, Schoonjans, Reinhilde, Störmer, Angela, Thielmann, Axel, Mühle, Uwe, Luch, Andreas

“…Development and market introduction of new nanomaterials trigger the need for an adequate risk assessment of such products alongside suitable risk…”
Get full text