Search Results - "Braeckmans, K"

Mucus-penetrating solid lipid nanoparticles for the treatment of cystic fibrosis: Proof of concept, challenges and pitfalls by Nafee, N., Forier, K., Braeckmans, K., Schneider, M.

“…[Display omitted] Nanocarrier-mediated transmucosal drug delivery based on conventional mucoadhesive, muco-inert or mucus-penetrating nanoparticles (NPs) is a…”
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Fluorescent Labeling of Plasmid DNA and mRNA: Gains and Losses of Current Labeling Strategies by Rombouts, K, Braeckmans, K, Remaut, K

“…Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be…”
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Chitosan nanoparticles for siRNA delivery: Optimizing formulation to increase stability and efficiency by Ragelle, H., Riva, R., Vandermeulen, G., Naeye, B., Pourcelle, V., Le Duff, C.S., D'Haese, C., Nysten, B., Braeckmans, K., De Smedt, S.C., Jérôme, C., Préat, V.

“…This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high…”
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Fertility preservation for trans men: frozen-thawed in vitro matured oocytes collected at the time of ovarian tissue processing exhibit normal meiotic spindles by Lierman, S., Tilleman, K., Braeckmans, K., Peynshaert, K., Weyers, S., T’Sjoen, G., De Sutter, P.

“…Purposes At the moment of sex reassignment surgery (SRS), the ovarian tissue is sometimes cryopreserved as fertility preservation option for female-to-male…”
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siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat by Al Soraj, M., He, L., Peynshaert, K., Cousaert, J., Vercauteren, D., Braeckmans, K., De Smedt, S.C., Jones, A.T.

“…Cell penetrating peptides (CPPs) have been extensively studied as vectors for cellular delivery of therapeutic macromolecules. It is widely accepted that they…”
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Photopolymerized thermosensitive hydrogels for tailorable diffusion-controlled protein delivery by Censi, R., Vermonden, T., van Steenbergen, M.J., Deschout, H., Braeckmans, K., De Smedt, S.C., van Nostrum, C.F., di Martino, P., Hennink, W.E.

“…In this paper the possibility to tailor degradation and protein release behavior of photopolymerized thermosensitive hydrogels is studied. The hydrogels…”
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Drying behaviour and visualization of surfactants after co-spray drying of surfactant-stabilized aqueous suspensions by De Pauw, E., Chen, Y., De Keersmaecker, H., De Coninck, E., De Smet, L., De Geest, B., Braeckmans, K., Vervaet, C., Vanhoorne, V.

“…[Display omitted] •Co-spray drying of suspensions with 0.1% polysorbate 80 resulted in sticky powder deposition in the transporters.•The stickiness was…”
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Synergism between particle-based multiplexing and microfluidics technologies may bring diagnostics closer to the patient by Derveaux, S, Stubbe, B. G, Braeckmans, K, Roelant, C, Sato, K, Demeester, J, De Smedt, S. C

“…In the field of medical diagnostics there is a growing need for inexpensive, accurate, and quick high-throughput assays. On the one hand, recent progress in…”
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An in vitro assay based on surface plasmon resonance to predict the in vivo circulation kinetics of liposomes by Crielaard, B.J., Yousefi, A., Schillemans, J.P., Vermehren, C., Buyens, K., Braeckmans, K., Lammers, T., Storm, G.

“…The adsorption of blood proteins onto liposomes and other colloidal particles is an important process influencing the circulation time. Proteins adsorbed to…”
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Laser-induced vapor nanobubbles improve diffusion in biofilms of antimicrobial agents for wound care by Teirlinck, E., Fraire, J.C., Van Acker, H., Wille, J., Swimberghe, R., Brans, T., Xiong, R., Meire, M., De Moor, R.J.G., De Smedt, S.C., Coenye, T., Braeckmans, K.

“…Being responsible for delayed wound healing, the presence of biofilms in infected wounds leads to chronic, and difficult to treat infections. One of the…”
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Pegylation of liposomes favours the endosomal degradation of the delivered phosphodiester oligonucleotides by Remaut, K., Lucas, B., Braeckmans, K., Demeester, J., De Smedt, S.C.

“…Liposomal vesicles have been widely investigated as carriers for the intracellular delivery of oligonucleotides (ONs). To avoid unspecific uptake by the…”
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Self-Rupturing Microcapsules by De Geest, B. G., Déjugnat, C., Sukhorukov, G. B., Braeckmans, K., De Smedt, S. C., Demeester, J.

“…Self‐rupturing microcapsules are prepared by layer‐by‐layer coating of degradable dextran‐hydroxyethyl methacrylate microgels with the polyelectrolytes…”
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Thiazolidinedione derivatives as novel agents against Propionibacterium acnes biofilms by Brackman, G, Forier, K, Al Quntar, A. A. A, De Canck, E, Enk, C. D, Srebnik, M, Braeckmans, K, Coenye, T

“…AIMS: The aim of the present study was to determine the effect of two thiazolidinedione derivatives on Propionibacterium acnes biofilm formation in vitro and…”
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Measuring absolute nanoparticle number concentrations from particle count time series by RÖDING, M., DESCHOUT, H., BRAECKMANS, K., RUDEMO, M.

“…Summary Single‐particle microscopy is important for characterization of nanoparticulate matter for which accurate concentration measurements are crucial. We…”
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Intravitreal mobility of nanoparticles: how to make a move toward successful ocular gene delivery? by Remaut, K., Devoldere, J., Peynshaert, K., Martens, T., Engbersen, J., Braeckmans, K., De Smedt, S.

“…Summary Intravitreal injection is an interesting delivery route for the administration of nanoparticles for treatment of a variety of retinopathies. To reach…”
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Effect of a low concentration of a cationic steroid antibiotic (CSA‐13) on the formation of a biofilm by Pseudomonas aeruginosa by Nagant, C, Feng, Y, Lucas, B, Braeckmans, K, Savage, P, Dehaye, J.P

“…Aims: Cationic steroids like CSA‐13 have been designed by analogy with antimicrobial cationic peptides and have bactericidal properties. The purpose of this…”
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Protection of Oligonucleotides against Enzymatic Degradation by Pegylated and Nonpegylated Branched Polyethyleneimine by Remaut, K, Lucas, B, Raemdonck, K, Braeckmans, K, Demeester, J, De Smedt, S. C

“…Among the cationic polymers, polyethyleneimine (PEI) is a promising candidate for delivery of oligodeoxynucleotides (ODNs). In this study, we wondered whether…”
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The choice of a suitable oligosaccharide to prevent aggregation of PEGylated nanoparticles during freeze thawing and freeze drying by Hinrichs, W.L.J., Manceñido, F.A., Sanders, N.N., Braeckmans, K., De Smedt, S.C., Demeester, J., Frijlink, H.W.

“…In a previous study we have shown that the oligosaccharide inulin can prevent aggregation of poly(ethylene glycol) (PEG) coated plasmid DNA/cationic liposome…”
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Self‐calibrated concentration measurements of polydisperse nanoparticles by RÖDING, M., DESCHOUT, H., BRAECKMANS, K., SÄRKKÄ, A., RUDEMO, M.

“…Summary Quantitative characterization of nanoparticles, e.g. accurate estimation of concentration distributions, is critical to many pharmaceutical and…”
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WS01.6 The rational design of nanomedicines for chronic pulmonary infection treatment: Does size really matter? by Forier, K, Messiaen, A.-S, Raemdonck, K, Nelis, H, De Smedt, S.C, Demeester, J, Coenye, T, Braeckmans, K

“…Objectives Several studies showed that encapsulating antibiotics in nanoparticles can improve the killing of biofilm bacteria. To ensure maximal delivery of…”
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