Search Results - "Brady, ST"

Tau pathology-mediated presynaptic dysfunction by Moreno, H, Morfini, G, Buitrago, L, Ujlaki, G, Choi, S, Yu, E, Moreira, J.E, Avila, J, Brady, S.T, Pant, H, Sugimori, M, Llinás, R.R

“…Highlights • htau42 in the presynaptic terminal induces calcium release from the ER. • The acute-modulation of IP3R and RyR by tau protein (directly or…”
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Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility by Morfini, Gerardo, Szebenyi, Györgyi, Elluru, Ravindhra, Ratner, Nancy, Brady, Scott T.

“…Membrane-bounded organelles (MBOs) are delivered to different domains in neurons by fast axonal transport. The importance of kinesin for fast antero grade…”
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A novel CDK5‐dependent pathway for regulating GSK3 activity and kinesin‐driven motility in neurons by Morfini, Gerardo, Szebenyi, Györgyi, Brown, Hannah, Pant, Harish C, Pigino, Gustavo, DeBoer, Scott, Beffert, Uwe, Brady, Scott T

“…Neuronal transmission of information requires polarized distribution of membrane proteins within axonal compartments. Membrane proteins are synthesized and…”
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Reelin-mediated Signaling Locally Regulates Protein Kinase B/Akt and Glycogen Synthase Kinase 3β by Beffert, Uwe, Morfini, Gerardo, Bock, Hans H., Reyna, Huichuan, Brady, Scott T., Herz, Joachim

“…Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor…”
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Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport by Pigino, Gustavo, Morfini, Gerardo, Pelsman, Alejandra, Mattson, Mark P, Brady, Scott T, Busciglio, Jorge

“…Several lines of evidence indicate that alterations in axonal transport play a critical role in Alzheimer's disease (AD) neuropathology, but the molecular…”
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Neuropathogenic Forms of Huntingtin and Androgen Receptor Inhibit Fast Axonal Transport by Szebenyi, Györgyi, Morfini, Gerardo A., Babcock, Alyssa, Gould, Milena, Selkoe, Kimberly, Stenoien, David L., Young, Maureen, Faber, Pieter W., MacDonald, Marcy E., McPhaul, Michael J., Brady, Scott T.

“…Huntington's and Kennedy's disease are autosomal dominant neurodegenerative diseases caused by pathogenic expansion of polyglutamine tracts. Expansion of…”
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1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C by Morfini, G, Pigino, G, Opalach, K, Serulle, Y, Moreira, J.E, Sugimori, M, Llinás, R.R, Brady, S.T

“…Parkinson's disease (PD), a late-onset condition characterized by dysfunction and loss of dopaminergic neurons in the substantia nigra, has both sporadic and…”
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Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited by Lazarov, Orly, Morfini, Gerardo A, Lee, Edward B, Farah, Mohamed H, Szodorai, Anita, DeBoer, Scott R, Koliatsos, Vassilis E, Kins, Stefan, Lee, Virginia M.-Y, Wong, Philip C, Price, Donald L, Brady, Scott T, Sisodia, Sangram S

“…The sequential enzymatic actions of beta-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the gamma-secretase complex liberate…”
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Studies on the pathogenesis of vincristine-induced neuropathy by Sahenk, Z, Brady, S T, Mendell, J R

“…The pathogenesis of the peripheral neuropathy induced by vincristine is poorly understood, but interference of vinca alkaloids with microtubule assembly…”
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Polyglutamine expansion diseases: failing to deliver by Morfini, Gerardo, Pigino, Gustavo, Brady, Scott T.

“…Polyglutamine (polyQ)-expansion diseases are dominantly inherited adult-onset neurodegenerative diseases with unknown pathogenic mechanisms. Current models for…”
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Neurofilaments Are Transported Rapidly But Intermittently in Axons: Implications for Slow Axonal Transport by Roy, Subhojit, Coffee, Pilar, Smith, George, Liem, Ronald K. H, Brady, Scott T, Black, Mark M

“…Slow axonal transport conveys cytoskeletal proteins from cell body to axon tip. This transport provides the axon with the architectural elements that are…”
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Activity-Driven Dendritic Remodeling Requires Microtubule-Associated Protein 1A by Szebenyi, Györgyi, Bollati, Flavia, Bisbal, Mariano, Sheridan, Shelley, Faas, Laura, Wray, Robin, Haferkamp, Scott, Nguyen, Sapril, Caceres, Alfredo, Brady, Scott T.

“…Activity-prompted dendritic remodeling [1, 2] leads to calcium-influx-dependent activation of signaling pathways within minutes and gene transcription within…”
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Reelin and Cyclin-Dependent Kinase 5-Dependent Signals Cooperate in Regulating Neuronal Migration and Synaptic Transmission by Beffert, Uwe, Weeber, Edwin J, Morfini, Gerardo, Ko, Jane, Brady, Scott T, Tsai, Li-Huei, Sweatt, J. David, Herz, Joachim

“…Neuronal migration and positioning in the developing brain require the coordinated interaction of multiple cellular signaling pathways. The extracellular…”
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Effects of Endothelin-1 on Components of Anterograde Axonal Transport in Optic Nerve by Stokely, Martha E, Brady, Scott T, Yorio, Thomas

“…Increased levels of endothelins (ETs) are associated with glaucoma and have been said to contribute to the development of glaucomatous optic neuropathy. In…”
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Direct interaction of microtubule- and actin-based transport motors by Huang, J. D., Brady, S. T., Richards, B. W., Stenolen, D., Resau, J. H., Copeland, N. G., Jenkins, N. A.

“…The microtubule network is thought to be used for long-range transport of cellular components in animal cells whereas the actin network is proposed to be used…”
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Transport of neurofilaments in growing axons requires microtubules but not actin filaments by Francis, Franto, Roy, Subhojit, Brady, Scott T., Black, Mark M.

“…Neurofilament (NF) polymers are conveyed from cell body to axon tip by slow axonal transport, and disruption of this process is implicated in several neuronal…”
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Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton by Brady, Scott T, Witt, Andrea S, Kirkpatrick, Laura L, de Waegh, Sylvie M, Readhead, Carol, Tu, Pang-Hsien, Lee, Virginia M.-Y

“…Although traditional roles ascribed to myelinating glial cells are structural and supportive, the importance of compact myelin for proper functioning of the…”
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Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis by Donelan, Matthew J., Morfini, Gerardo, Julyan, Richard, Sommers, Scott, Hays, Lori, Kajio, Hiroshi, Briaud, Isabelle, Easom, Richard A., Molkentin, Jeffery D., Brady, Scott T., Rhodes, Christopher J.

“…The specific biochemical steps required for glucose-regulated insulin exocytosis from beta-cells are not well defined. Elevation of glucose leads to increases…”
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Fast axonal transport misregulation and Alzheimer's disease by Morfini, Gerardo, Pigino, Gustavo, Beffert, Uwe, Busciglio, Jorge, Brady, Scott T

“…Pathological alterations in the microtubule-associated protein (MAP) tau are well-established in a number of neurodegenerative disorders, including Alzheimer's…”
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Gender differences in response of hippocampus to chronic glucocorticoid stress: Role of glutamate receptors by Liu, Howard H., Payne, H. Ross, Wang, Bin, Brady, Scott T.

“…Glucocorticoids (GC) play critical roles in the pathophysiological reactions to environmental stress. In brain, morphological changes were examined in…”
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