Search Results - "Brady, Nathan R."

Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling by Ugolino, Janet, Ji, Yon Ju, Conchina, Karen, Chu, Justin, Nirujogi, Raja Sekhar, Pandey, Akhilesh, Brady, Nathan R, Hamacher-Brady, Anne, Wang, Jiou

“…The most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia is a hexanucleotide repeat expansion in…”
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Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells by Eling, Nils, Reuter, Lukas, Hazin, John, Hamacher-Brady, Anne, Brady, Nathan R

“…Oncogenic KRas reprograms pancreatic ductal adenocarcinoma (PDAC) cells to states which are highly resistant to apoptosis. Thus, a major preclinical goal is to…”
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Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins by Rogov, Vladimir V., Suzuki, Hironori, Marinković, Mija, Lang, Verena, Kato, Ryuichi, Kawasaki, Masato, Buljubašić, Maja, Šprung, Matilda, Rogova, Natalia, Wakatsuki, Soichi, Hamacher-Brady, Anne, Dötsch, Volker, Dikic, Ivan, Brady, Nathan R., Novak, Ivana

“…The mitophagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria into autophagosomes for degradation. Here we present evidence for…”
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Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival Mitophagy versus Apoptosis by Zhu, Yanyan, Massen, Stefan, Terenzio, Marco, Lang, Verena, Chen-Lindner, Silu, Eils, Roland, Novak, Ivana, Dikic, Ivan, Hamacher-Brady, Anne, Brady, Nathan R.

“…BH3-only proteins integrate apoptosis and autophagy pathways, yet regulation and functional consequences of pathway cross-talk are not fully resolved. The…”
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Enhancing Macroautophagy Protects against Ischemia/Reperfusion Injury in Cardiac Myocytes by Hamacher-Brady, Anne, Brady, Nathan R., Gottlieb, Roberta A.

“…Cardiac myocytes undergo programmed cell death as a result of ischemia/reperfusion (I/R). One feature of I/R injury is the increased presence of…”
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Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles by Coelho, Carolina, Brown, Lisa, Maryam, Maria, Vij, Raghav, Smith, Daniel F.Q., Burnet, Meagan C., Kyle, Jennifer E., Heyman, Heino M., Ramirez, Jasmine, Prados-Rosales, Rafael, Lauvau, Gregoire, Nakayasu, Ernesto S., Brady, Nathan R., Hamacher-Brady, Anne, Coppens, Isabelle, Casadevall, Arturo

“…Outer membrane vesicles produced by Gram-negative bacteria have been studied for half a century but the possibility that Gram-positive bacteria secrete…”
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Metabolic programs define dysfunctional immune responses in severe COVID-19 patients by Thompson, Elizabeth A., Cascino, Katherine, Ordonez, Alvaro A., Zhou, Weiqiang, Vaghasia, Ajay, Hamacher-Brady, Anne, Brady, Nathan R., Sun, Im-Hong, Wang, Rulin, Rosenberg, Avi Z., Delannoy, Michael, Rothman, Richard, Fenstermacher, Katherine, Sauer, Lauren, Shaw-Saliba, Kathyrn, Bloch, Evan M., Redd, Andrew D., Tobian, Aaron A.R., Horton, Maureen, Smith, Kellie, Pekosz, Andrew, D’Alessio, Franco R., Yegnasubramanian, Srinivasan, Ji, Hongkai, Cox, Andrea L., Powell, Jonathan D.

“…It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop severe disease. By interrogating metabolic programs of immune cells…”
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Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62 by Metz, Philippe, Chiramel, Abhilash, Chatel-Chaix, Laurent, Alvisi, Gualtiero, Bankhead, Peter, Mora-Rodriguez, Rodrigo, Long, Gang, Hamacher-Brady, Anne, Brady, Nathan R, Bartenschlager, Ralf

“…Autophagic flux involves formation of autophagosomes and their degradation by lysosomes. Autophagy can either promote or restrict viral replication. In the…”
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Artesunate Activates Mitochondrial Apoptosis in Breast Cancer Cells via Iron-catalyzed Lysosomal Reactive Oxygen Species Production by Hamacher-Brady, Anne, Stein, Henning A., Turschner, Simon, Toegel, Ina, Mora, Rodrigo, Jennewein, Nina, Efferth, Thomas, Eils, Roland, Brady, Nathan R.

“…The antimalarial agent artesunate (ART) activates programmed cell death (PCD) in cancer cells in a manner dependent on the presence of iron and the generation…”
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Histone deacetylase 10 promotes autophagy-mediated cell survival by Oehme, Ina, Linke, Jan-Peter, Böck, Barbara C, Milde, Till, Lodrini, Marco, Hartenstein, Bettina, Wiegand, Inga, Eckert, Christian, Roth, Wilfried, Kool, Marcel, Kaden, Sylvia, Gröne, Hermann-Josef, Schulte, Johannes H, Lindner, Sven, Hamacher-Brady, Anne, Brady, Nathan R, Deubzer, Hedwig E, Witt, Olaf

“…Tumor cells activate autophagy in response to chemotherapy-induced DNA damage as a survival program to cope with metabolic stress. Here, we provide in vitro…”
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Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy by Hundeshagen, Phillip, Hamacher-Brady, Anne, Eils, Roland, Brady, Nathan R

“…Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and…”
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Disruption of neuronal autophagy by infected microglia results in neurodegeneration by Alirezaei, Mehrdad, Kiosses, William B, Flynn, Claudia T, Brady, Nathan R, Fox, Howard S

“…There is compelling evidence to support the idea that autophagy has a protective function in neurons and its disruption results in neurodegenerative disorders…”
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NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1 by BALTEAU, Magali, TAJEDDINE, Nicolas, HUE, Louis, BERTRAND, Luc, BEAULOYE, Christophe, DE MEESTER, Carole, GINION, Audrey, DES ROSIERS, Christine, BRADY, Nathan R, SOMMEREYNS, Caroline, HORMAN, Sandrine, VANOVERSCHELDE, Jean-Louis, GAILLY, Philippe

“…Exposure to high glucose (HG) stimulates reactive oxygen species (ROS) production by NADPH oxidase in cardiomyocytes, but the underlying mechanism remains…”
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Divergent roles of autophagy in virus infection by Chiramel, Abhilash I, Brady, Nathan R, Bartenschlager, Ralf

“…Viruses have played an important role in human evolution and have evolved diverse strategies to co-exist with their hosts. As obligate intracellular pathogens,…”
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A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria by Brady, Nathan R, Hamacher-Brady, Anne, Westerhoff, Hans V, Gottlieb, Roberta A

“…Once considered simply as the main source of ATP, mitochondria are now implicated in the control of many additional aspects of cell physiology, such as calcium…”
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The autophagic response to nutrient deprivation in the hl‐1 cardiac myocyte is modulated by Bcl‐2 and sarco/endoplasmic reticulum calcium stores by Brady, Nathan R., Hamacher‐Brady, Anne, Yuan, Hua, Gottlieb, Roberta A.

“…Macroautophagy is a vital process in the cardiac myocyte: it plays a protective role in the response to ischemic injury, and chronic perturbation is causative…”
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Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors by Brady, Nathan R., Hamacher-Brady, Anne, Gottlieb, Roberta A.

“…The objective of this study was to evaluate mitochondrial alterations in a cell-based model of myocardial ischemia/reperfusion (I/R) injury. Using…”
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Data-derived modeling characterizes plasticity of MAPK signaling in melanoma by Bernardo-Faura, Marti, Massen, Stefan, Falk, Christine S, Brady, Nathan R, Eils, Roland

“…The majority of melanomas have been shown to harbor somatic mutations in the RAS-RAF-MEK-MAPK and PI3K-AKT pathways, which play a major role in regulation of…”
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Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis by Reis, Yara, Bernardo-Faura, Marti, Richter, Daniela, Wolf, Thomas, Brors, Benedikt, Hamacher-Brady, Anne, Eils, Roland, Brady, Nathan R

“…Mitochondria exist as a network of interconnected organelles undergoing constant fission and fusion. Current approaches to study mitochondrial morphology are…”
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Autophagy as a Protective Response to Bnip3-Mediated Apoptotic Signaling in the Heart by Hamacher-Brady, Anne, Brady, Nathan R, Gottlieb, Roberta A., Gustafsson, Åsa B.

“…Bnip3 is a member of the 'BH3-only' Bcl-2 subfamily which has been implicated in apoptotic, necrotic, and autophagic cell death. We recently reported that…”
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