Search Results - "Brady, Madeleine C"

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis by WILKINSON, Robert W, ODEDRA, Rajesh, BYTH, Kate F, BARRASS, Nigel C, MUNDT, Kirsten E, FOOTE, Kevin M, HERON, Nicola M, JUNG, Frederic H, MORTLOCK, Andrew A, BOYLE, F. Thomas, GREEN, Stephen, HEATON, Simon P, WEDGE, Stephen R, KEEN, Nicholas J, CRAFTER, Claire, FOSTER, John R, BRADY, Madeleine C, BIGLEY, Alison, BROWN, Elaine

“…Purpose: In the current study, we examined the in vivo effects of AZD1152, a novel and specific inhibitor of Aurora kinase activity (with selectivity for…”
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Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase by Mortlock, Andrew A, Foote, Kevin M, Heron, Nicola M, Jung, Frédéric H, Pasquet, Georges, Lohmann, Jean-Jacques M, Warin, Nicolas, Renaud, Fabrice, De Savi, Chris, Roberts, Nicola J, Johnson, Trevor, Dousson, Cyril B, Hill, George B, Perkins, David, Hatter, Glenn, Wilkinson, Robert W, Wedge, Stephen R, Heaton, Simon P, Odedra, Rajesh, Keen, Nicholas J, Crafter, Claire, Brown, Elaine, Thompson, Katherine, Brightwell, Stephen, Khatri, Liz, Brady, Madeleine C, Kearney, Sarah, McKillop, David, Rhead, Steve, Parry, Tony, Green, Stephen

“…The Aurora kinases have been the subject of considerable interest as targets for the development of new anticancer agents. While evidence suggests inhibition…”
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Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity by Foote, Kevin M., Mortlock, Andrew A., Heron, Nicola M., Jung, Frédéric H., Hill, George B., Pasquet, Georges, Brady, Madeleine C., Green, Stephen, Heaton, Simon P., Kearney, Sarah, Keen, Nicholas J., Odedra, Rajesh, Wedge, Stephen R., Wilkinson, Robert W.

“…A new class of 1-acetanilide-4-aminopyrazole-substituted quinazoline Aurora kinase inhibitors has been discovered possessing highly potent cellular activity…”
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Design and campaign synthesis of pyridine-based histone deacetylase inhibitors by Andrews, David M., Gibson, Keith M., Graham, Mark A., Matusiak, Zbigniew S., Roberts, Craig A., Stokes, Elaine S.E., Brady, Madeleine C., Chresta, Christine M.

“…The synthesis of the HDAC inhibitor 13b is reported. (HDAC1 enzyme pIC 50 8.01.) A lead benzamide, bearing a cyanopyridyl moiety ( 3), was identified as a…”
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Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors by Andrews, David M., Stokes, Elaine S.E., Carr, Greg R., Matusiak, Zbigniew S., Roberts, Craig A., Waring, Michael J., Brady, Madeleine C., Chresta, Christine M., East, Simon J.

“…The synthesis of the HDAC inhibitor 16d is reported. (HDAC1 enzyme pIC 50 7.46. A549a xenograft efficacy at 12.5 mg/kg.) A lead benzamide, 3, was identified as…”
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Studies on haemosiderin and ferritin from iron-loaded rat liver by Andrews, S C, Brady, M C, Treffry, A, Williams, J M, Mann, S, Cleton, M I, de Bruijn, W, Harrison, P M

“…Haemosiderin has been isolated from siderosomes and ferritin from the cytosol of livers of rats iron-loaded by intraperitoneal injections of iron-dextran…”
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