Search Results - "Brady, Jamie L."

GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis by Ko, Hyun-Ja, Brady, Jamie L, Ryg-Cornejo, Victoria, Hansen, Diana S, Vremec, David, Shortman, Ken, Zhan, Yifan, Lew, Andrew M

“…Although multiple dendritic cell (DC) subsets have the potential to induce Th17 differentiation in vitro, the key DC that is critical in Th17 induction and…”
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A high-throughput screening RT-qPCR assay for quantifying surrogate markers of immunity from PBMCs by Browne, Daniel J., Kelly, Ashton M., Brady, Jamie L., Doolan, Denise L.

“…Immunoassays that quantitate cytokines and other surrogate markers of immunity from peripheral blood mononuclear cells (PBMCs), such as flow cytometry or…”
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An Analytically and Diagnostically Sensitive RNA Extraction and RT-qPCR Protocol for Peripheral Blood Mononuclear Cells by Browne, Daniel J, Brady, Jamie L, Waardenberg, Ashley J, Loiseau, Claire, Doolan, Denise L

“…Reliable extraction and sensitive detection of RNA from human peripheral blood mononuclear cells (PBMCs) is critical for a broad spectrum of immunology…”
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Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9 by Nottle, Mark B., Salvaris, Evelyn J., Fisicaro, Nella, McIlfatrick, Stephen, Vassiliev, Ivan, Hawthorne, Wayne J., O’Connell, Philip J., Brady, Jamie L., Lew, Andrew M., Cowan, Peter J.

“…Xenotransplantation from pigs has been advocated as a solution to the perennial shortage of donated human organs and tissues. CRISPR/Cas9 has facilitated the…”
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Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells by Carrington, Emma M., Zhang, Jian-Guo, Sutherland, Robyn M., Vikstrom, Ingela B., Brady, Jamie L., Soo, Priscilla, Vremec, David, Allison, Cody, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe, Grabow, Stephanie, Ottina, Eleonora, Herold, Marco J., Pellegrini, Marc, Huang, David C. S., Tarlinton, David M., Strasser, Andreas, Lew, Andrew M., Zhan, Yifan

“…Dendritic cells (DCs) are heterogeneous, comprising subsets with functional specializations that play distinct roles in immunity as well as immunopathology. We…”
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The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions by Jiao, Zhijun, Bedoui, Sammy, Brady, Jamie L, Walter, Anne, Chopin, Michael, Carrington, Emma M, Sutherland, Robyn M, Nutt, Stephen L, Zhang, Yuxia, Ko, Hyun-Ja, Wu, Li, Lew, Andrew M, Zhan, Yifan

“…Migratory CD103+ and lymphoid-resident CD8+ dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting…”
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Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ by Sutherland, Robyn M., Londrigan, Sarah L., Brady, Jamie L., Carrington, Emma M., Marchingo, Julia M., Heinzel, Susanne, Hodgkin, Philip D., Graham, Kate L., Kay, Thomas W., Zhan, Yifan, Lew, Andrew M.

“…T-cell responses are initiated upon cognate presentation by professional antigen presenting cells in lymphoid tissue. T cells then migrate to inflamed tissues,…”
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Resident and monocyte-derived dendritic cells become dominant IL-12 producers under different conditions and signaling pathways by Zhan, Yifan, Xu, Yuekang, Seah, Shirley, Brady, Jamie L, Carrington, Emma M, Cheers, Christina, Croker, Ben A, Wu, Li, Villadangos, Jose A, Lew, Andrew M

“…IL-12 is such a pivotal cytokine that it has been called the third signal for T cell activation, TCR engagement being the first and costimulation being the…”
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A novel population of memory‐activated natural killer cells associated with low parasitaemia in Plasmodium falciparum‐exposed sickle‐cell trait children by Loiseau, Claire, Doumbo, Ogobara K, Traore, Boubacar, Brady, Jamie L, Proietti, Carla, Sousa, Karina P, Crompton, Peter D, Doolan, Denise L

“…Objectives The sickle‐cell trait phenotype is associated with protection from malaria. Multiple molecular mechanisms have been proposed to explain this…”
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Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle‐cell trait children by Loiseau, Claire, Traore, Boubacar, Ongoiba, Aissata, Kayentao, Kassoum, Doumbo, Safiatou, Doumtabe, Didier, Sousa, Karina P, Brady, Jamie L, Proietti, Carla, Crompton, Peter D, Doolan, Denise L

“…Objectives Study of individuals with protection from Plasmodium falciparum (Pf) infection and clinical malaria, including individuals affected by the…”
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Antigen delivery via two molecules on the CD8– dendritic cell subset induces humoral immunity in the absence of conventional “danger” by Corbett, Alexandra J., Caminschi, Irina, McKenzie, Brent S., Brady, Jamie L., Wright, Mark D., Mottram, Patricia L., Hogarth, P. Mark, Hodder, Anthony N., Zhan, Yifan, Tarlinton, David M., Shortman, Ken, Lew, Andrew M.

“…Targeting antigen to dendritic cells (DC) in vivo might be an effective method of modulating immune responses. Given the functional specializations among DC…”
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Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response by Seah, Shirley G. K., Brady, Jamie L., Carrington, Emma M., Ng, Wy Ching, Sutherland, Robyn M., Hancock, Manuela S., La Gruta, Nicole L., Brown, Lorena E., Turner, Stephen J., Lew, Andrew M., Zhan, Yifan

“…Direct costimulation of CD8+ T cells is more important than the canonical licensing of DCs by CD4 help, in influenza. The helper‐dependent pathway of priming…”
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Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo by Carrington, Emma M, Zhan, Yifan, Brady, Jamie L, Zhang, Jian-Guo, Sutherland, Robyn M, Anstee, Natasha S, Schenk, Robyn L, Vikstrom, Ingela B, Delconte, Rebecca B, Segal, David, Huntington, Nicholas D, Bouillet, Philippe, Tarlinton, David M, Huang, David CS, Strasser, Andreas, Cory, Suzanne, Herold, Marco J, Lew, Andrew M

“…Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T…”
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Versatile co-expression of graft-protective proteins using 2A-linked cassettes by Fisicaro, Nella, Londrigan, Sarah L., Brady, Jamie L., Salvaris, Evelyn, Nottle, Mark B., O'Connell, Philip J., Robson, Simon C., d'Apice, Anthony J. F., Lew, Andrew M., Cowan, Peter J.

“…Fisicaro N, Londrigan SL, Brady JL, Salvaris E, Nottle MB, O’Connell PJ, Robson SC, d’Apice AJF, Lew AM, Cowan PJ. Versatile co‐expression of graft‐protective…”
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DNA Immunization: Induction of Higher Avidity Antibody and Effect of Route on T Cell Cytotoxicity by Boyle, J S, Silva, A, Brady, J L, Lew, A M

“…Immunizations of mice with plasmid DNAs encoding ovalbumin (OVA), human Ig, and hen egg lysozyme were compared with doses of soluble protein (without adjuvant)…”
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Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan by Zhan, Yifan, Chow, Kevin V., Soo, Priscilla, Xu, Zhen, Brady, Jamie L., Lawlor, Kate E., Masters, Seth L., O’keeffe, Meredith, Shortman, Ken, Zhang, Jian-Guo, Lew, Andrew M.

“…Plasmacytoid dendritic cells (pDCs) play an important role in immunity to certain pathogens and immunopathology in some autoimmune diseases. They are thought…”
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Bcl‐2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus‐Prone Mice and Dampen Interferon‐α Production by Zhan, Yifan, Carrington, Emma M., Ko, Hyun‐Ja, Vikstrom, Ingela B., Oon, Shereen, Zhang, Jian‐Guo, Vremec, David, Brady, Jamie L., Bouillet, Philippe, Wu, Li, Huang, David C. S., Wicks, Ian P., Morand, Eric F., Strasser, Andreas, Lew, Andrew M.

“…Objective Interferon‐α (IFNα)–producing plasmacytoid dendritic cells (PDCs) are implicated in the pathogenesis of systemic lupus erythematosus (SLE)…”
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TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death by Zhan, Yifan, Funda, David P., Every, Alison L., Fundova, Petra, Purton, Jared F., Liddicoat, Douglas R., Cole, Timothy J., Godfrey, Dale I., Brady, Jamie L., Mannering, Stuart I., Harrison, Leonard C., Lew, Andrew M.

“…T lymphocytes (pivotal in many inflammatory pathologies) are targets for glucocorticoid hormone (GC). How TCR-mediated activation and GC signaling via…”
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Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells by Johnson, Susan, Zhan, Yifan, Sutherland, Robyn M., Mount, Adele M., Bedoui, Sammy, Brady, Jamie L., Carrington, Emma M., Brown, Lorena E., Belz, Gabrielle T., Heath, William R., Lew, Andrew M.

“…CD40L (CD154) on CD4 + T cells has been shown to license dendritic cells (DCs) via CD40 to prime cytotoxic T lymphocyte (CTL) responses. We found that the…”
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CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation by Zhan, Yifan, Corbett, Alexandra J, Brady, Jamie L, Sutherland, Robyn M, Lew, Andrew M

“…Mice made transgenic (Tg) for a rat anti-mouse CD4 Ab (GK mice) represent a novel CD4-deficient model. They not only lack canonical CD4 cells in the periphery,…”
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