Search Results - "Brady, J N"

Human T-cell leukemia virus type 1 Tax attenuates γ-irradiation-induced apoptosis through physical interaction with Chk2 by PARK, H. U, JEONG, S.-J, JEONG, J.-H, CHUNG, J. H, BRADY, J. N

“…Checkpoint kinase 2 (Chk2) is known to mediate diverse cellular responses to genotoxic stress. The fundamental role of Chk2 is to regulate the network of…”
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The tax protein from the primate T-cell lymphotropic virus type 3 is expressed in vivo and is functionally related to HTLV-1 Tax rather than HTLV-2 Tax by CHEVALIER, S. A, MEERTENS, L, MAHIEUX, R, PISE-MASISON, C, CALATTINI, S, PARK, H, ALHAJ, A. A, ZHOU, M, GESSAIN, A, KASHANCHI, F, BRADY, J. N

“…Human T-cell leukemia virus and simian T-cell leukemia virus (STLV) form the primate T-cell lymphotropic viruses group. Human T-cell leukemia virus type 1 and…”
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A Protective Role for Cyclooxygenase-2 in Drug-Induced Liver Injury in Mice by Reilly, Timothy P, Brady, John N, Marchick, Michael R, Bourdi, Mohammed, George, John W, Radonovich, Michael F, Pise-Masison, Cynthia A, Pohl, Lance R

“…Despite the utility of cyclooxygenase (COX) inhibition as an antiinflammatory strategy, prostaglandin (PG) products of COX-1 and -2 provide important…”
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Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein by Cvekl, A, Kashanchi, F, Brady, JN, Piatigorsky, J

“…To identify proteins that physically interact with Pax-6, a paired domain- and homeodomain (HD)-containing transcription factor that is a key regulator of eye…”
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Cell Cycle Regulation of Human Interleukin-8 Gene Expression by the Human Immunodeficiency Virus Type 1 Tat Protein by Mahieux, R, Lambert, P F, Agbottah, E, Halanski, M A, Deng, L, Kashanchi, F, Brady, J N

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Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax by Pise-Masison, C A, Mahieux, R, Radonovich, M, Jiang, H, Duvall, J, Guillerm, C, Brady, J N

“…The p53 protein plays a pivotal role in transmitting signals from many forms of genotoxic stress to genes and factors that control aspects of the cell cycle…”
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Direct interaction of human TFIID with the HIV-1 transactivator Tat by Kashanchi, Fatah, Piras, Graziella, Radonovich, Michael F, Duvall, Janet F, Fattaey, Ali, Chiang, Cheng-Ming, Roeder, Robert G, Brady, John N

“…The tat gene of the human immunodeficiency virus (HIV) plays a central role in the activation and life cycle of HIV. The tat protein (Tat) specifically…”
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Transcriptional and post-transcriptional gene regulation of HTLV-1 by Kashanchi, Fatah, Brady, John N

“…Adult T-cell leukemia (ATL) is an aggressive hematologic malignancy caused by human T-cell leukemia virus type I (HTLV-1). Tax, encoded by the HTLV-1 pX…”
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Inactivation of p53 by HTLV type 1 and HTLV type 2 Tax trans-activators by Mahieux, R, Pise-Masison, C A, Nicot, C, Green, P, Hall, W W, Brady, J N

“…Human T cell lymphotropic virus type II (HTLV-2) was originally isolated from a patient with a hairy T cell leukemia. It has been associated with rare cases of…”
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Extracellular Tax1 protein stimulates tumor necrosis factor-beta and immunoglobulin kappa light chain expression in lymphoid cells by LINDHOLM, P. F, REID, R. L, BRADY, J. N

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Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site by Cvekl, Aleš, Kashanchi, Fatah, Sax, Christina M., Brady, John N., Piatigorsky, Joram

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HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300 by NICOT, C, MAHIEUX, R, OPAVSKY, R, CERESETO, A, WOLFF, L, BRADY, J. N, FRANCHINI, G

“…The c-Myb proto-oncogene is preferentially expressed in hematopoietic lineages, and highly expressed in several leukemia types. The Human T-cell Leukemia Virus…”
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Activated AKT regulates NF-κB activation, p53 inhibition and cell survival in HTLV-1-transformed cells by JEONG, Soo-Jin, PISE-MASISON, Cynthia A, RADONOVICH, Michael F, HYEON UNG PARK, BRADY, John N

“…AKT activation enhances resistance to apoptosis and induces cell survival signaling through multiple downstream pathways. We now present evidence that AKT is…”
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Tax oncoprotein trans-represses endogenous B-myb promoter activity in human T cells by Nicot, C, Opavsky, R, Mahieux, R, Johnson, J M, Brady, J N, Wolff, L, Franchini, G

“…The B-myb gene was identified on the basis of its homology with the protooncogene c-myb, homolog of the avian myeloblastosis virus (AMV) and avian leukemia…”
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Human herpesvirus 6 (HHV-6) ORF-1 transactivating gene exhibits malignant transforming activity and its protein binds to p53 by KASHANCHI, F, ARAUJO, J, LUPPI, M, TORELLI, G, ROSENTHAL, L. J, DONIGER, J, MURALIDHAR, S, HOCH, R, KHLEIF, S, MENDELSON, E, THOMPSON, J, AZUMI, N, BRADY, J. N

“…The 357 amino acid open reading frame 1 (ORF-1), also designated DR7, within the SalI-L fragment of human herpesvirus 6 (HHV-6) exhibited transactivation of…”
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Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax by Cowan, E P, Alexander, R K, Daniel, S, Kashanchi, F, Brady, J N

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Transactivation of the P2 promoter of parathyroid hormone-related protein by human T-cell lymphotropic virus type I Tax1: evidence for the involvement of transcription factor Ets1 by DITTMER, J, GITLIN, S. D, REID, R. L, BRADY, J. N

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Regulation of insulin-like growth factor II P3 promoter by p53 : A potential mechanism for tumorigenesis by LIJUAN ZHANG, KASHANCHI, F, QIMIN ZHAN, SHILI ZHAN, BRADY, J. N, FORNACE, A. J, SETH, P, HELMAN, L. J

“…Human insulin-like growth factor (IGF)-II mRNA has been shown to be expressed at high levels in a variety of tumors, including rhabdomyosarcomas. In addition,…”
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Inhibition of human immunodeficiency virus type 1 transcription and replication by DNA sequence-selective plant lignans by Gnabre, J N, Brady, J N, Clanton, D J, Ito, Y, Dittmer, J, Bates, R B, Huang, R C

“…A plant lignan, 3'-O-methyl nordihydroguaiaretic acid (3'-O-methyl NDGA, denoted Malachi 4:5-6 or Mal.4; molecular weight 316), was isolated from Larrea…”
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Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression by KASHANCHI, F, DUVALL, J. F, DITTMER, J, MIRESKANDARI, A, REID, R. L, GITLIN, S. D, BRADY, J. N

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