Search Results - "Brady, Hugh J M"

Composition, Development, and Function of Uterine Innate Lymphoid Cells by Doisne, Jean-Marc, Balmas, Elisa, Boulenouar, Selma, Gaynor, Louise M, Kieckbusch, Jens, Gardner, Lucy, Hawkes, Delia A, Barbara, Cynthia F, Sharkey, Andrew M, Brady, Hugh J M, Brosens, Jan J, Moffett, Ashley, Colucci, Francesco

“…Innate lymphoid cells (ILCs), including NK cells, contribute to barrier immunity and tissue homeostasis. In addition to the role of uterine NK cells in…”
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Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development by Kostrzewski, Tomasz, Borg, Aaron J, Meng, Yiran, Filipovic, Iva, Male, Victoria, Wack, Andreas, DiMaggio, Peter A, Brady, Hugh J M

“…The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this…”
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Interleukin-2 shapes the cytotoxic T cell proteome and immune environment-sensing programs by Rollings, Christina M, Sinclair, Linda V, Brady, Hugh J M, Cantrell, Doreen A, Ross, Sarah H

“…Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein synthesis to promote the differentiation of effector CD8 cytotoxic…”
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Transcriptional control of natural killer cell differentiation and function by Martín-Fontecha, Alfonso, Lord, Graham M., Brady, Hugh J. M.

“…Gene expression can be modulated depending on physiological and developmental requirements. A multitude of regulatory genes, which are organized in…”
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The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development by Brady, Hugh J M, Coles, Mark, Long, Elaine, Williams, Owen, Veiga-Fernandes, Henrique, Seddon, Benedict, Gascoyne, Duncan M, Kioussis, Dimitris, de Boer, Jasper

“…Little is known about the transcription factors that facilitate NK cell differentiation. Brady and colleagues find that the basic leucine zipper transcription…”
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Differential requirement for Nfil3 during NK cell development by Seillet, Cyril, Huntington, Nicholas D, Gangatirkar, Pradnya, Axelsson, Elin, Minnich, Martina, Brady, Hugh J M, Busslinger, Meinrad, Smyth, Mark J, Belz, Gabrielle T, Carotta, Sebastian

“…NK cells can be grouped into distinct subsets that are localized to different organs and exhibit a different capacity to secrete cytokines and mediate…”
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Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity by Lee, Byung-Cheol, Kim, Myung-Sunny, Pae, Munkyong, Yamamoto, Yasuhiko, Eberlé, Delphine, Shimada, Takeshi, Kamei, Nozomu, Park, Hee-Sook, Sasorith, Souphatta, Woo, Ju Rang, You, Jia, Mosher, William, Brady, Hugh J.M., Shoelson, Steven E., Lee, Jongsoon

“…Obesity-induced inflammation mediated by immune cells in adipose tissue appears to participate in the pathogenesis of insulin resistance. We show that natural…”
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ERG Is a Megakaryocytic Oncogene by SALEK-ARDAKANI, Samira, SMOOHA, Gil, DE BOER, Jasper, SEBIRE, Neil J, MORROW, Michelle, RAINIS, Liat, LEE, Sandy, WILLIAMS, Owen, IZRAELI, Shai, BRADY, Hugh J. M

“…Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on Hsa21. ERG is known to have a crucial role in establishing definitive…”
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E4BP4: an unexpected player in the immune response by Male, Victoria, Nisoli, Ilaria, Gascoyne, Duncan M, Brady, Hugh J.M

“…Until recently, the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) was of little interest to immunologists, being best known for its…”
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Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia by Stam, Ronald W., Den Boer, Monique L., Schneider, Pauline, de Boer, Jasper, Hagelstein, Jill, Valsecchi, Maria G., de Lorenzo, Paola, Sallan, Stephen E., Brady, Hugh J.M., Armstrong, Scott A., Pieters, Rob

“…MLL-rearranged acute lymphoblastic leukemia (ALL) represents an unfavorable type of leukemia that often is highly resistant to glucocorticoids such as…”
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The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy by Boulenouar, Selma, Doisne, Jean-Marc, Sferruzzi-Perri, Amanda, Gaynor, Louise M, Kieckbusch, Jens, Balmas, Elisa, Yung, Hong Wa, Javadzadeh, Shagayegh, Volmer, Léa, Hawkes, Delia A, Phillips, Keli, Brady, Hugh J M, Fowden, Abigail L, Burton, Graham J, Moffett, Ashley, Colucci, Francesco

“…Uterine NK cells are innate lymphoid cells (ILC) that populate the uterus and expand during pregnancy, regulating placental development and fetal growth in…”
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Mcl-1 Interacts with Truncated Bid and Inhibits Its Induction of Cytochrome c Release and Its Role in Receptor-mediated Apoptosis by Clohessy, John G., Zhuang, Jianguo, de Boer, Jasper, Gil-Gómez, Gabriel, Brady, Hugh J.M.

“…Engagement of death receptors such as tumor necrosis factor-R1 and Fas brings about the cleavage of cytosolic Bid to truncated Bid (tBid), which translocates…”
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ILC Lineage Specification: To Be or Not 11b, That Is the Question by Kostrzewski, Tomasz, Brady, Hugh J.M.

“…The transcription factor Bcl11b is important for T cell development and maintaining their phenotype. In this issue of Immunity, Califano et al. (2015) show…”
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TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity by Morrow, Michelle, Horton, Sarah, Kioussis, Dimitris, Brady, Hugh J.M., Williams, Owen

“…The t(12;21)(p13;q22) translocation is the most common chromosomal abnormality yet identified in any pediatric leukemia and gives rise to the TEL-AML1 fusion…”
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AML1/ETO Proteins Control POU4F1/BRN3A Expression and Function in t(8;21) Acute Myeloid Leukemia by DUNNE, Jenny, GASCOYNE, Duncan M, LISTER, T. Andrew, BRADY, Hugh J. M, HEIDENREICH, Olaf, YOUNG, Bryan D

“…A variety of genetic lesions, including chromosomal translocations, internal tandem duplications, and mutations, have been described in acute myeloid leukemia…”
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Characterisation of Mcl‐1 cleavage during apoptosis of haematopoietic cells by Clohessy, John G., Zhuang, Jianguo, Brady, Hugh J. M.

“…Summary Mcl‐1 is essential for normal haematopoiesis, being required for lymphocyte development and maintenance. Its role in haematopoietic differentiation and…”
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The Ikaros splice isoform, Ikaros 6, immortalizes murine haematopoietic progenitor cells by Ruiz, Anna, Williams, Owen, Brady, Hugh J.M.

“…Alternative pre‐mRNA splicing is emerging as a major control point in both the initiation and progression of tumourigenesis. Overexpression of the dominant…”
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The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression by Male, Victoria, Nisoli, Ilaria, Kostrzewski, Tomasz, Allan, David S J, Carlyle, James R, Lord, Graham M, Wack, Andreas, Brady, Hugh J M

“…The transcription factor E4bp4 (Nfil3) is essential for natural killer (NK) cell production. Here, we show that E4bp4 is required at the NK lineage commitment…”
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The transcriptional repressor REV-ERB as a novel target for disease by Uriz-Huarte, Amaia, Date, Amrita, Ang, Heather, Ali, Simak, Brady, Hugh J.M., Fuchter, Matthew J.

“…[Display omitted] REV-ERB is a member of the nuclear receptor superfamily of transcription factors involved in the regulation of many physiological processes,…”
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Roscovitine Modulates DNA Repair and Senescence: Implications for Combination Chemotherapy by CRESCENZI, Elvira, PALUMBO, Giuseppe, BRADY, Hugh J. M

“…Purpose: Treatment of tumor cells by chemotherapy activates a series of responses ranging from apoptosis to premature senescence and repair. Survival responses…”
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