Search Results - "Bradshaw, William J"

Bidirectional contact tracing could dramatically improve COVID-19 control by Bradshaw, William J., Alley, Ethan C., Huggins, Jonathan H., Lloyd, Alun L., Esvelt, Kevin M.

“…Contact tracing is critical to controlling COVID-19, but most protocols only “forward-trace” to notify people who were recently exposed. Using a stochastic…”
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Molecular features of the sortase enzyme family by Bradshaw, William J, Davies, Abigail H, Chambers, Christopher J, Roberts, April K, Shone, Clifford C, Acharya, K. Ravi

“…Bacteria possess complex and varying cell walls with many surface exposed proteins. Sortases are responsible for the covalent attachment of specific proteins…”
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Analysis of the first genetic engineering attribution challenge by Crook, Oliver M., Warmbrod, Kelsey Lane, Lipstein, Greg, Chung, Christine, Bakerlee, Christopher W., McKelvey, T. Greg, Holland, Shelly R., Swett, Jacob L., Esvelt, Kevin M., Alley, Ethan C., Bradshaw, William J.

“…The ability to identify the designer of engineered biological sequences—termed genetic engineering attribution (GEA)—would help ensure due credit for…”
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Extreme genomic volatility characterizes the evolution of the immunoglobulin heavy chain locus in cyprinodontiform fishes by Bradshaw, William J, Valenzano, Dario Riccardo

“…The evolution of the adaptive immune system has provided vertebrates with a uniquely sophisticated immune toolkit, enabling them to mount precise immune…”
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Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2 by Bradshaw, William J, Kennedy, Emma C, Moreira, Tiago, Smith, Luke A, Chalk, Rod, Katis, Vittorio L, Benesch, Justin L P, Brennan, Paul E, Murphy, Emma J, Gileadi, Opher

“…SHIP1, an inositol 5-phosphatase, plays a central role in cellular signaling. As such, it has been implicated in many conditions. Exploiting SHIP1 as a drug…”
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Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile by Bradshaw, William J., Bruxelle, Jean-François, Kovacs-Simon, Andrea, Harmer, Nicholas J., Janoir, Claire, Péchiné, Severine, Acharya, K. Ravi, Michell, Stephen L.

“…Clostridioides difficile is the primary cause of antibiotic-associated diarrhea and colitis, a healthcare-associated intestinal disease resulting in a…”
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Assessing the safety of new germicidal far‐UVC technologies by Görlitz, Maximilian, Justen, Lennart, Rochette, Patrick J., Buonanno, Manuela, Welch, David, Kleiman, Norman J., Eadie, Ewan, Kaidzu, Sachiko, Bradshaw, William J., Javorsky, Emilia, Cridland, Nigel, Galor, Anat, Guttmann, Martin, Meinke, Martina C., Schleusener, Johannes, Jensen, Paul, Söderberg, Per, Yamano, Nozomi, Nishigori, Chikako, O'Mahoney, Paul, Manstein, Dieter, Croft, Rodney, Cole, Curtis, Gruijl, Frank R., Forbes, Paul Donald, Trokel, Stephen, Marshall, John, Brenner, David J., Sliney, David, Esvelt, Kevin

“…The COVID‐19 pandemic underscored the crucial importance of enhanced indoor air quality control measures to mitigate the spread of respiratory pathogens…”
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Structural insights into human angiogenin variants implicated in Parkinson’s disease and Amyotrophic Lateral Sclerosis by Bradshaw, William J., Rehman, Saima, Pham, Tram T. K., Thiyagarajan, Nethaji, Lee, Rebecca L., Subramanian, Vasanta, Acharya, K. Ravi

“…Mutations in Angiogenin ( ANG ), a member of the Ribonuclease A superfamily (also known as RNase 5) are known to be associated with Amyotrophic Lateral…”
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Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease by Du, Yuhong, Bradshaw, William J., Leisner, Tina M., Annor-Gyamfi, Joel K., Qian, Kun, Bashore, Frances M., Sikdar, Arunima, Nwogbo, Felix O., Ivanov, Andrey A., Frye, Stephen V., Gileadi, Opher, Brennan, Paul E., Levey, Allan I., Axtman, Alison D., Pearce, Kenneth H., Fu, Haian, Katis, Vittorio L.

“…Proteomic studies have identified moesin (MSN), a protein containing a four-point-one, ezrin, radixin, moesin (FERM) domain, and the receptor CD44 as hub…”
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Cwp2 from Clostridium difficile exhibits an extended three domain fold and cell adhesion in vitro by Bradshaw, William J., Kirby, Jonathan M., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…Colonization of the gut by Clostridium difficile requires the adhesion of the bacterium to host cells. A range of cell surface located factors have been linked…”
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The molecular structure of the glycoside hydrolase domain of Cwp19 from Clostridium difficile by Bradshaw, William J., Kirby, Jonathan M., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…Clostridium difficile is a burden to healthcare systems around the world, causing tens of thousands of deaths annually. The S‐layer of the bacterium, a layer…”
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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM by Bashore, Frances M, Katis, Vittorio L, Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J, Rygiel, Karolina A, Leisner, Tina M, Chalk, Rod, Mishra, Swati, Williams, C Andrew, Gileadi, Opher, Brennan, Paul E, Wiley, Jesse C, Gockley, Jake, Cary, Gregory A, Carter, Gregory W, Young, Jessica E, Pearce, Kenneth H, Fu, Haian, Axtman, Alison D

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative…”
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The structure of the S-layer of Clostridium difficile by Bradshaw, William J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…The nosocomially acquired pathogen Clostridium difficile is the primary causative agent of antibiotic associated diarrhoea and causes tens of thousands of…”
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The structure of the cysteine protease and lectin-like domains of Cwp84, a surface layer-associated protein from Clostridium difficile by Bradshaw, William J., Kirby, Jonathan M., Thiyagarajan, Nethaji, Chambers, Christopher J., Davies, Abigail H., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…Clostridium difficile is a major problem as an aetiological agent for antibiotic‐associated diarrhoea. The mechanism by which the bacterium colonizes the gut…”
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Cwp84, a Clostridium difficile cysteine protease, exhibits conformational flexibility in the absence of its propeptide by Bradshaw, William J., Roberts, April K., Shone, Clifford C., Acharya, K. Ravi

“…In recent decades, the global healthcare problems caused by Clostridium difficile have increased at an alarming rate. A greater understanding of this…”
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Effect of a Simulated Tactical Occupation Stressor on Reaction Time: 2954 Board #237 June 1 3: 30 PM - 5: 00 PM by Hussey, Andrew J., Morris, Cody E., Winchester, Lee J., Tomes, Ariel S., Neal, Wesley A., Wilcoxen, Damon M., Anderson, MiRanda N., Bradshaw, William J., Lucas, Dana N., Chander, Harish, Arnett, Scott W.

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Effect of a Simulated Tactical Occupation Stressor on Immune System Markers of Physiological Stress and Inflammation: 2953 Board #236 June 1 3: 30 PM - 5: 00 PM by Tomes, Ariel S., Morris, Cody E., Winchester, Lee, Hussey, Andrew J., Neal, Wesley A., Wilcoxen, Damon M., Anderson, MiRanda N., Bradshaw, William J., Lucas, Dana N., Chander, Harish, Arnett, Scott W.

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Effect of a Simulated Tactical Occupation Stressor on Physiological Strain Index and Blood Pressure: 2951 Board #234 June 1 3: 30 PM - 5: 00 PM by Morris, Cody E., Winchester, Lee J., Hussey, Andrew J., Tomes, Ariel S., Neal, Wesley A., Wilcoxen, Damon M., Anderson, MiRanda N., Bradshaw, William J., Lucas, Dana N., Chander, Harish, Arnett, Scott W.

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM by Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, William J Bradshaw, Karolina A Rygiel, Tina M Leisner, Rod Chalk, Swati Mishra, C Andrew Williams, Opher Gileadi, Paul E Brennan, Jesse C Wiley, Jake Gockley, Gregory A Cary, Gregory W Carter, Jessica E Young, Kenneth H Pearce, Haian Fu, Emory-Sage-SGC TREAT-AD Center, Alison D Axtman

“…RNA sequencing and genetic data support spleen tyrosine kinase (SYK) and high affinity immunoglobulin epsilon receptor subunit gamma (FCER1G) as putative…”
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Analysis of the first Genetic Engineering Attribution Challenge by Crook, Oliver M, Warmbrod, Kelsey Lane, Lipstein, Greg, Chung, Christine, Bakerlee, Christopher W, McKelveyJr, T. Greg, Holland, Shelly R, Swett, Jacob L, Esvelt, Kevin M, Alley, Ethan C, Bradshaw, William J

“…The ability to identify the designer of engineered biological sequences -- termed genetic engineering attribution (GEA) -- would help ensure due credit for…”
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