Search Results - "Bradshaw, M"

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain by Felsky, Daniel, Roostaei, Tina, Nho, Kwangsik, Risacher, Shannon L., Bradshaw, Elizabeth M., Petyuk, Vlad, Schneider, Julie A., Saykin, Andrew, Bennett, David A., De Jager, Philip L.

“…Microglia, the resident immune cells of the brain, have important roles in brain health. However, little is known about the regulation and consequences of…”
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A transcriptomic atlas of aged human microglia by Olah, Marta, Patrick, Ellis, Villani, Alexandra-Chloe, Xu, Jishu, White, Charles C., Ryan, Katie J., Piehowski, Paul, Kapasi, Alifiya, Nejad, Parham, Cimpean, Maria, Connor, Sarah, Yung, Christina J., Frangieh, Michael, McHenry, Allison, Elyaman, Wassim, Petyuk, Vlad, Schneider, Julie A., Bennett, David A., De Jager, Philip L., Bradshaw, Elizabeth M.

“…With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise. However, these efforts…”
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Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells by Elyaman, Wassim, Bassil, Ribal, Bradshaw, Elizabeth M., Orent, William, Lahoud, Youmna, Zhu, Bing, Radtke, Freddy, Yagita, Hideo, Khoury, Samia J.

“…Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4+FoxP3+ T regulatory (Treg) cell survival and…”
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Trust in Automation by Hoffman, R. R., Johnson, M., Bradshaw, J. M., Underbrink, A.

“…This essay focuses on trust in the automation within macrocognitive work systems. The authors emphasize the dynamics of trust. They consider numerous different…”
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Polyfunctional responses by human T cells result from sequential release of cytokines by Han, Qing, Bagheri, Neda, Bradshaw, Elizabeth M., Hafler, David A., Lauffenburger, Douglas A., Love, J. Christopher

“…The release of cytokines by T cells defines a significant part of their functional activity in vivo, and their ability to produce multiple cytokines has been…”
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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology by Bradshaw, Elizabeth M, Chibnik, Lori B, Keenan, Brendan T, Ottoboni, Linda, Raj, Towfique, Tang, Anna, Rosenkrantz, Laura L, Imboywa, Selina, Lee, Michelle, Von Korff, Alina, Morris, Martha C, Evans, Denis A, Johnson, Keith, Sperling, Reisa A, Schneider, Julie A, Bennett, David A, De Jager, Philip L

“…Genome-wide association studies have identified CD33 as an Alzheimer's disease susceptibility locus. Here, the authors show that the CD33 risk allele is…”
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Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish by Sebag, Julien A., Zhang, Chao, Hinkle, Patricia M., Bradshaw, Amanda M., Cone, Roger D.

“…The melanocortin-4 receptor (MC4R) is essential for control of energy homeostasis in vertebrates. MC4R interacts with melanocortin receptor accessory protein 2…”
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Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis by Dineen, R. A., Vilisaar, J., Hlinka, J., Bradshaw, C. M., Morgan, P. S., Constantinescu, C. S., Auer, D. P.

“…Disconnection of cognitively important processing regions by injury to the interconnecting white matter provides a potential mechanism for cognitive…”
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Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine by Banda, Douglas M., Nuñez, Nicole N., Burnside, Michael A., Bradshaw, Katie M., David, Sheila S.

“…Reactive oxygen and nitrogen species (RONS) may infringe on the passing of pristine genetic information by inducing DNA inter- and intra-strand crosslinks,…”
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Deconvolving the contributions of cell-type heterogeneity on cortical gene expression by Patrick, Ellis, Taga, Mariko, Ergun, Ayla, Ng, Bernard, Casazza, William, Cimpean, Maria, Yung, Christina, Schneider, Julie A, Bennett, David A, Gaiteri, Chris, De Jager, Philip L, Bradshaw, Elizabeth M, Mostafavi, Sara

“…Complexity of cell-type composition has created much skepticism surrounding the interpretation of bulk tissue transcriptomic studies. Recent studies have shown…”
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Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor by Dingal, P. C. Dave P., Bradshaw, Andrew M., Cho, Sangkyun, Raab, Matthew, Buxboim, Amnon, Swift, Joe, Discher, Dennis E.

“…Scarring is a long-lasting problem in higher animals, and reductionist approaches could aid in developing treatments. Here, we show that copolymerization of…”
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IL-9 induces differentiation of TH17 cells and enhances function of FoxP3⁺ natural regulatory T cells by Elyaman, Wassim, Bradshaw, Elizabeth M, Uyttenhove, Catherine, Dardalhon, Valérie, Awasthi, Amit, Imitola, Jaime, Bettelli, Estelle, Oukka, Mohamed, van Snick, Jacques, Renauld, Jean-Christophe, Kuchroo, Vijay K, Khoury, Samia J

“…The development of T helper (TH)17 and regulatory T (Treg) cells is reciprocally regulated by cytokines. Transforming growth factor (TGF)-β alone induces…”
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CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility by Raj, Towfique, Ryan, Katie J., Replogle, Joseph M., Chibnik, Lori B., Rosenkrantz, Laura, Tang, Anna, Rothamel, Katie, Stranger, Barbara E., Bennett, David A., Evans, Denis A., De Jager, Philip L., Bradshaw, Elizabeth M.

“…We previously demonstrated that the Alzheimer's disease (AD) associated risk allele, rs3865444C, results in a higher surface density of CD33 on monocytes…”
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The gut microbiota is associated with psychiatric symptom severity and treatment outcome among individuals with serious mental illness by Madan, A., Thompson, D., Fowler, J.C., Ajami, N.J., Salas, R., Frueh, B.C., Bradshaw, M.R., Weinstein, B.L., Oldham, J.M., Petrosino, J.F.

“…•Depression and anxiety among psychiatric inpatients were negatively associated with richness, alpha diversity, and specific bacterial taxa.•Microbiota…”
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Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving by Han, Qing, Bradshaw, Elizabeth M, Nilsson, Björn, Hafler, David A, Love, J Christopher

“…The large diversity of cells that comprise the human immune system requires methods that can resolve the individual contributions of specific subsets to an…”
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Prevalence and patterns of cognitive impairment in sporadic ALS by RINGHOLZ, G. M, APPEL, S. H, BRADSHAW, M, COOKE, N. A, MOSNIK, D. M, SCHULZ, P. E

“…To investigate the prevalence and nature of cognitive changes associated with sporadic amyotrophic lateral sclerosis (ALS) using a large scale study…”
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Molecular orbital tomography for adsorbed molecules: is a correct description of the final state really unimportant? by Bradshaw, A M, Woodruff, D P

“…The application of the 'orbital tomography' technique to obtain direct images of molecular orbitals of adsorbed molecules from angle-resolved photoemission…”
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The Seven Deadly Myths of "Autonomous Systems" by Bradshaw, J. M., Hoffman, R. R., Johnson, M., Woods, D. D.

“…As designers conceive and implement what are commonly (but mistakenly) called autonomous systems, they adhere to certain myths of autonomy that are not only…”
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Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccination by Jergović, Mladen, Uhrlaub, Jennifer L., Watanabe, Makiko, Bradshaw, Christine M., White, Lisa M., LaFleur, Bonnie J., Edwards, Taylor, Sprissler, Ryan, Worobey, Michael, Bhattacharya, Deepta, Nikolich-Žugich, Janko

“…Aging is associated with a reduced magnitude of primary immune responses to vaccination. mRNA-based SARS-CoV-2 vaccines have shown efficacy in older adults but…”
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Multiscale relationships between fibronectin structure and functional properties by Bradshaw, M.J., Smith, M.L.

“…Cell behavior is tightly coupled to the properties of the extracellular matrix (ECM) to which they attach. Fibronectin (Fn) forms a supermolecular, fibrillar…”
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