Search Results - "Bradshaw, Curt"

Identification of a Tricyclic P III Chiral Auxiliary for Solid-Supported Synthesis of Stereopure Phosphorothioate-Containing Oligonucleotides by Sakamuri, Sukumar, Liu, Dingguo, Eltepu, Laxman, Liu, Bin, Reboton, Lisa Jo, Preston, Ryan, Bradshaw, Curt W

“…Since the recognition of oligonucleotides as a therapeutic modality, significant work has been devoted to improving therapeutic properties, including nuclease…”
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Impact of Phosphorothioate Chirality on Double‐Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs by Sakamuri, Sukumar, Eltepu, Laxman, Liu, Dingguo, Lam, Son, Meade, Bryan R., Liu, Bin, Dello Iacono, Giuseppe, Kabakibi, Ayman, Luukkonen, Lena, Leedom, Tom, Foster, Mark, Bradshaw, Curt W.

“…Oligonucleotides are important therapeutic approaches, as evidenced by recent clinical successes with antisense oligonucleotides (ASOs) and double‐stranded…”
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Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody by Huang, Jie, Ishino, Tetsuya, Chen, Gang, Rolzin, Paul, Osothprarop, Trina F, Retting, Kelsey, Li, Lingna, Jin, Ping, Matin, Marla J, Huyghe, Bernard, Talukdar, Saswata, Bradshaw, Curt W, Palanki, Moorthy, Violand, Bernard N, Woodnutt, Gary, Lappe, Rodney W, Ogilvie, Kathleen, Levin, Nancy

“…Fibroblast growth factor (FGF)21 improves insulin sensitivity, reduces body weight, and reverses hepatic steatosis in preclinical species. We generated…”
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Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth by HANHUA HUANG, LAI, Jing-Yu, WOODNUTT, Gary, LAPPE, Rodney, BHAT, Abhijit, JANET DO, DINGGUO LIU, LINGNA LI, DEL ROSARIO, Joselyn, DOPPALAPUDI, Venkata R, PIRIE-SHEPHERD, Steven, LEVIN, Nancy, BRADSHAW, Curt

“…Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of…”
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Identification of a Tricyclic PIII Chiral Auxiliary for Solid‐Supported Synthesis of Stereopure Phosphorothioate‐Containing Oligonucleotides by Sakamuri, Sukumar, Liu, Dingguo, Eltepu, Laxman, Liu, Bin, Reboton, Lisa Jo, Preston, Ryan, Bradshaw, Curt W.

“…Since the recognition of oligonucleotides as a therapeutic modality, significant work has been devoted to improving therapeutic properties, including nuclease…”
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Chemical generation of bispecific antibodies by Doppalapudi, Venkata R., Huang, Jie, Liu, Dingguo, Jin, Ping, Liu, Bin, Li, Lingna, Desharnais, Joel, Hagen, Crystal, Levin, Nancy J., Shields, Michael J., Parish, Michelle, Murphy, Robert E., Rosario, Joselyn Del, Oates, Bryan D., Lai, Jing-Yu, Matin, Marla J., Ainekulu, Zemeda, Bhat, Abhijit, Bradshaw, Curt W., Woodnutt, Gary, Lerner, Richard A., Lappe, Rodney W.

“…Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their ability to simultaneously bind two different antigens. Several…”
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Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide by Liu, Shenping, Desharnais, Joel, Sahasrabudhe, Parag V., Jin, Ping, Li, Wei, Oates, Bryan D., Shanker, Suman, Banker, Mary Ellen, Chrunyk, Boris A., Song, Xi, Feng, Xidong, Griffor, Matt, Jimenez, Judith, Chen, Gang, Tumelty, David, Bhat, Abhijit, Bradshaw, Curt W., Woodnutt, Gary, Lappe, Rodney W., Thorarensen, Atli, Qiu, Xiayang, Withka, Jane M., Wood, Lauren D.

“…IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have…”
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615 Targeted immune cell activation by systemic delivery of toll-like receptor 9 agonist antibody conjugates induce potent anti-tumor immunity by Harrabi, Ons, Chen, Amy, Sangalang, Emma, Doyle, Laura, Fontaine, Danielle, Han, Bora, Bradshaw, Curt, Pons, Jaume, Sim, Janet, Kuo, Tracy, Wan, Hong

“…BackgroundToll-like receptor (TLR) pathways play a crucial role in mounting potent innate immune responses against invading pathogens, as well as the…”
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Antitumor Efficacy of a Thrombospondin 1 Mimetic CovX-Body by Li, Lingna, Leedom, Tom A, Do, Janet, Huang, Hanhua, Lai, JingYu, Johnson, Kim, Osothprarop, Trina F, Rizzo, John D, Doppalapudi, Venkata R, Bradshaw, Curt W, Lappe, Rodney W, Woodnutt, Gary, Levin, Nancy J, Pirie-Shepherd, Steven R

“…Abstract CVX-045 is produced by covalently attaching a thrombospondin 1 (TSP-1) mimetic comprising a peptidic sequence and a linker to the Fab binding site of…”
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Lactobacillus kefir alcohol dehydrogenase: a useful catalyst for synthesis by Bradshaw, Curt W, Hummel, Werner, Wong, Chi Huey

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A Pseudomonas sp. alcohol dehydrogenase with broad substrate specificity and unusual stereospecificity for organic synthesis by Bradshaw, Curt W, Fu, Hong, Shen, Gwo Jenn, Wong, Chi Huey

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Development of novel linkers to conjugate pharmacophores to a carrier antibody by Palanki, Moorthy S.S., Bhat, Abhijit, Lappe, Rodney W., Liu, Bin, Oates, Bryan, Rizzo, John, Stankovic, Nebojsa, Bradshaw, Curt

“…We have developed modified maleimide novel linkers with improved chemical stability that could potentially be used in conjugating various pharmacophores such…”
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Specificity of antibody-catalyzed transesterifications using enol esters: a comparison with lipase reactions by Fernholz, Erhard, Schloeder, Diane, Liu, Kevin K. C, Bradshaw, Curt W, Huang, Hongmei, Janda, Kim, Lerner, Richard A, Wong, Chi Huey

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Chemically programmed antibodies: Endothelin receptor targeting CovX-Bodies by Doppalapudi, Venkata R., Tryder, Nancy, Li, Lingna, Aja, Teresa, Griffith, David, Liao, Francesca-Fang, Roxas, Giovanni, Ramprasad, Mysore P., Bradshaw, Curt, Barbas, Carlos F.

“…β-Diketone containing aryl sulfonamide endothelin antagonists were synthesized and covalently linked to the reactive lysine of the antibody m38C2 to create a…”
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Evolution of Potent and Stable Placental-Growth-Factor-1-Targeting CovX-Bodies from Phage Display Peptide Discovery by Bower, Kristen E, Lam, Son N, Oates, Bryan D, del Rosario, Joselyn R, Corner, Emily, Osothprarop, Trina F, Kinhikar, Arvind G, Hoye, Julie A, Preston, R. Ryan, Murphy, Robert E, Campbell, Lioudmila A, Huang, Hanhua, Jimenez, Judith, Cao, Xia, Chen, Gang, Ainekulu, Zemeda W, Datt, Aakash B, Levin, Nancy J, Doppalapudi, Venkata R, Pirie-Shepherd, Steven R, Bradshaw, Curt, Woodnutt, Gary, Lappe, Rodney W

“…Novel phage-derived peptides are the first reported molecules specifically targeting human placental growth factor 1 (PlGF-1). Phage data enabled peptide…”
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Synthesis of a novel analytical reagent for the determination of active sites for conjugation on a catalytic aldolase monoclonal antibody by Magano, Javier, Farrand, Douglas, Haase, Jeffrey P., Lovdahl, Michael, Maloney, Mark T., Pozzo, Mark J., Teixeira, John J., Whritenour, David C., Rizzo, John, Tumelty, David, Bhat, Abhijit, Bradshaw, Curt

“…An optimized and scalable synthesis of a novel analytical reagent for the determination of the number of active sites available for conjugation on a catalytic…”
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Enzymatic synthesis of (R) and (S) 1-deuterohexanol by BRADSHAW, C. W, LALONDE, J. J, CHI-HUEY WONG

“…This paper describes practical enzymatic procedures for the synthesis of (R) and (S) 1-deuterohexanol, a useful building block for chiral poly isocyanated…”
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Cofactor-requiring redox enzymes in organic synthesis by Bradshaw, Curt William

“…New nicotinamide cofactor dependent alcohol dehydrogenases from Pseudomonas strains SBD6 and PED have been purified to homogeneity using a combination of salt…”
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