Search Results - "Bradman, Neil"

Tracing the Route of Modern Humans out of Africa by Using 225 Human Genome Sequences from Ethiopians and Egyptians by Pagani, Luca, Schiffels, Stephan, Gurdasani, Deepti, Danecek, Petr, Scally, Aylwyn, Chen, Yuan, Xue, Yali, Haber, Marc, Ekong, Rosemary, Oljira, Tamiru, Mekonnen, Ephrem, Luiselli, Donata, Bradman, Neil, Bekele, Endashaw, Zalloua, Pierre, Durbin, Richard, Kivisild, Toomas, Tyler-Smith, Chris

“…The predominantly African origin of all modern human populations is well established, but the route taken out of Africa is still unclear. Two alternative…”
Get full text

World-wide distributions of lactase persistence alleles and the complex effects of recombination and selection by Liebert, Anke, López, Saioa, Jones, Bryony Leigh, Montalva, Nicolas, Gerbault, Pascale, Lau, Winston, Thomas, Mark G., Bradman, Neil, Maniatis, Nikolas, Swallow, Dallas M.

“…The genetic trait of lactase persistence (LP) is associated with at least five independent functional single nucleotide variants in a regulatory region about…”
Get full text

Evidence of the interplay of genetics and culture in Ethiopia by López, Saioa, Tarekegn, Ayele, Band, Gavin, van Dorp, Lucy, Bird, Nancy, Morris, Sam, Oljira, Tamiru, Mekonnen, Ephrem, Bekele, Endashaw, Blench, Roger, Thomas, Mark G., Bradman, Neil, Hellenthal, Garrett

“…The rich linguistic, ethnic and cultural diversity of Ethiopia provides an unprecedented opportunity to understand the level to which cultural factors…”
Get full text

Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference by van Dorp, Lucy, Balding, David, Myers, Simon, Pagani, Luca, Tyler-Smith, Chris, Bekele, Endashaw, Tarekegn, Ayele, Thomas, Mark G, Bradman, Neil, Hellenthal, Garrett

“…The Ari peoples of Ethiopia are comprised of different occupational groups that can be distinguished genetically, with Ari Cultivators and the socially…”
Get full text

Diversity of Lactase Persistence Alleles in Ethiopia: Signature of a Soft Selective Sweep by Jones, Bryony L., Raga, Tamiru O., Liebert, Anke, Zmarz, Pawel, Bekele, Endashaw, Danielsen, E. Thomas, Olsen, Anders Krüger, Bradman, Neil, Troelsen, Jesper T., Swallow, Dallas M.

“…The persistent expression of lactase into adulthood in humans is a recent genetic adaptation that allows the consumption of milk from other mammals after…”
Get full text

Prevalence of Clinically Relevant UGT1A Alleles and Haplotypes in African Populations by Horsfall, Laura J., Zeitlyn, David, Tarekegn, Ayele, Bekele, Endashaw, Thomas, Mark G., Bradman, Neil, Swallow, Dallas M.

“…Summary Variation of a short (TA)n repeat sequence (rs8175347) covering the TATA box of UGT1A1 (UDP‐glucuronosyltransferase1A1) is associated with…”
Get full text

CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme by Browning, Sarah L, Tarekegn, Ayele, Bekele, Endashaw, Bradman, Neil, Thomas, Mark G

“…BACKGROUND AND OBJECTIVESCYP1A2 metabolizes various drugs, endogenous compounds and procarcinogens. As human genetic diversity has been reported to decrease…”
Get full text

Kenin Alan Brook: The Maternal Genetic Lineages of Ashkenazic Jews: Academic Studies Press, 2022, 208 pp by Bradman, Neil

Get full text

The potentially deleterious functional variant flavin-containing monooxygenase 21 is at high frequency throughout sub-Saharan Africa by Veeramah, Krishna R, Thomas, Mark G, Weale, Michael E, Zeitlyn, David, Tarekegn, Ayele, Bekele, Endashaw, Mendell, Nancy R, Shephard, Elizabeth A, Bradman, Neil, Phillips, Ian R

“…BACKGROUNDThe drug-metabolizing enzyme flavin-containing monooxygenase 2 (FMO2) is the predominant FMO isoform present in the lung of most mammals, including…”
Get full text

Genetic Evidence for Different Male and Female Roles during Cultural Transitions in the British Isles by Wilson, James F., Weiss, Deborah A., Richards, Martin, Thomas, Mark G., Bradman, Neil, Goldstein, David B.

“…Human history is punctuated by periods of rapid cultural change. Although archeologists have developed a range of models to describe cultural transitions, in…”
Get full text

Y Chromosomes Traveling South: The Cohen Modal Haplotype and the Origins of the Lemba—the “Black Jews of Southern Africa” by Thomas, Mark G., Parfitt, Tudor, Weiss, Deborah A., Skorecki, Karl, Wilson, James F., le Roux, Magdel, Bradman, Neil, Goldstein, David B.

“…The Lemba are a traditionally endogamous group speaking a variety of Bantu languages who live in a number of locations in southern Africa. They claim descent…”
Get full text

Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa by Bains, Ripudaman K, Kovacevic, Mirna, Plaster, Christopher A, Tarekegn, Ayele, Bekele, Endashaw, Bradman, Neil N, Thomas, Mark G

“…Cytochrome P450 3A5 (CYP3A5) is an enzyme involved in the metabolism of many therapeutic drugs. CYP3A5 expression levels vary between individuals and…”
Get full text

Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of Nigeria by Veeramah, Krishna R, Connell, Bruce A, Ansari Pour, Naser, Powell, Adam, Plaster, Christopher A, Zeitlyn, David, Mendell, Nancy R, Weale, Michael E, Bradman, Neil, Thomas, Mark G

“…The Cross River region in Nigeria is an extremely diverse area linguistically with over 60 distinct languages still spoken today. It is also a region of great…”
Get full text

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene by Tzur, Shay, Rosset, Saharon, Shemer, Revital, Yudkovsky, Guennady, Selig, Sara, Tarekegn, Ayele, Bekele, Endashaw, Bradman, Neil, Wasser, Walter G, Behar, Doron M, Skorecki, Karl

“…MYH9 has been proposed as a major genetic risk locus for a spectrum of nondiabetic end stage kidney disease (ESKD). We use recently released sequences from the…”
Get full text

Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations by Huerta-Sánchez, Emilia, Degiorgio, Michael, Pagani, Luca, Tarekegn, Ayele, Ekong, Rosemary, Antao, Tiago, Cardona, Alexia, Montgomery, Hugh E, Cavalleri, Gianpiero L, Robbins, Peter A, Weale, Michael E, Bradman, Neil, Bekele, Endashaw, Kivisild, Toomas, Tyler-Smith, Chris, Nielsen, Rasmus

“…The Tibetan and Andean Plateaus and Ethiopian highlands are the largest regions to have long-term high-altitude residents. Such populations are exposed to…”
Get full text

Ancient West African foragers in the context of African population history by Lipson, Mark, Ribot, Isabelle, Mallick, Swapan, Rohland, Nadin, Olalde, Iñigo, Adamski, Nicole, Broomandkhoshbacht, Nasreen, Lawson, Ann Marie, López, Saioa, Oppenheimer, Jonas, Stewardson, Kristin, Asombang, Raymond Neba’ane, Bocherens, Hervé, Bradman, Neil, Culleton, Brendan J., Cornelissen, Els, Crevecoeur, Isabelle, de Maret, Pierre, Fomine, Forka Leypey Mathew, Lavachery, Philippe, Mindzie, Christophe Mbida, Orban, Rosine, Sawchuk, Elizabeth, Semal, Patrick, Thomas, Mark G., Van Neer, Wim, Veeramah, Krishna R., Kennett, Douglas J., Patterson, Nick, Hellenthal, Garrett, Lalueza-Fox, Carles, MacEachern, Scott, Prendergast, Mary E., Reich, David

“…Our knowledge of ancient human population structure in sub-Saharan Africa, particularly prior to the advent of food production, remains limited. Here we report…”
Get full text

Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene Pool by Pagani, Luca, Kivisild, Toomas, Tarekegn, Ayele, Ekong, Rosemary, Plaster, Chris, Gallego Romero, Irene, Ayub, Qasim, Mehdi, S. Qasim, Thomas, Mark G., Luiselli, Donata, Bekele, Endashaw, Bradman, Neil, Balding, David J., Tyler-Smith, Chris

“…Humans and their ancestors have traversed the Ethiopian landscape for millions of years, and present-day Ethiopians show great cultural, linguistic, and…”
Get full text

High-throughput analysis of informative CYP2D6 compound haplotypes by Fletcher, Benjamin, Goldstein, David B, Bradman, Amanda L.R, Weale, Michael E, Bradman, Neil, Thomas, Mark G

“…We describe a high-throughput protocol for detecting key polymorphisms in the drug-metabolizing enzyme gene CYP2D6 and a number of linked microsatellites that…”
Get full text

An African American Paternal Lineage Adds an Extremely Ancient Root to the Human Y Chromosome Phylogenetic Tree by Mendez, Fernando L., Krahn, Thomas, Schrack, Bonnie, Krahn, Astrid-Maria, Veeramah, Krishna R., Woerner, August E., Fomine, Forka Leypey Mathew, Bradman, Neil, Thomas, Mark G., Karafet, Tatiana M., Hammer, Michael F.

“…We report the discovery of an African American Y chromosome that carries the ancestral state of all SNPs that defined the basal portion of the Y chromosome…”
Get full text

Evidence from Y-chromosome analysis for a late exclusively eastern expansion of the Bantu-speaking people by Ansari Pour, Naser, Plaster, Christopher A, Bradman, Neil

“…The expansion of the Bantu-speaking people (EBSP) during the past 3000-5000 years is an event of great importance in the history of humanity. Anthropology,…”
Get full text