Search Results - "Bradlow, H Leon"

Associations of polychlorinated biphenyl exposure and endogenous hormones with diabetes in post-menopausal women previously employed at a capacitor manufacturing plant by Persky, Victoria, Piorkowski, Julie, Turyk, Mary, Freels, Sally, Chatterton, Robert, Dimos, John, Leon Bradlow, H., Kaatz Chary, Lin, Burse, Virlyn, Unterman, Terry, Sepkovic, Daniel, McCann, Kenneth

“…There is an increasing body of literature showing associations of organochlorine exposure with risk of diabetes and insulin resistance. Some studies suggest…”
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3,3'-Diindolylmethane and genistein decrease the adverse effects of estrogen in LNCaP and PC-3 prostate cancer cells by Smith, Sunyata, Sepkovic, Daniel, Bradlow, H Leon, Auborn, Karen J

“…Evidence suggests that 17beta-estradiol (E2) contributes to the risk of prostate cancer (PCa), whereas the phytochemicals genistein from soy and…”
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Diindolylmethane Inhibits Cervical Dysplasia, Alters Estrogen Metabolism, and Enhances Immune Response in the K14-HPV16 Transgenic Mouse Model by SEPKOVIC, Daniel W, STEIN, Johann, CARLISTE, Antoine D, KSIESKI, H. Barbara, AUBORN, Karen, BRADLOW, H. Leon

“…This study was designed to establish whether 3,3′-diindolylmethane (DIM) can inhibit cervical lesions, alter estrogen metabolism in favor of C-2 hydroxylation,…”
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Environmental Toxins and Breast Cancer on Long Island. II. Organochlorine Compound Levels in Blood by GAMMON, Marilie D, WOLFF, Mary S, HATCH, Maureen, SENIE, Ruby, BERKOWITZ, Gertrud, BRADLOW, H. Leon, GARBOWSKI, Gail, MAFFEO, Carla, MONTALVAN, Pat, KEMENY, Margaret, CITRON, Marc, SCHNABEL, Freya, NEUGUT, Alfred I, SCHUSS, Allan, HAJDU, Steven, VINCEGUERRA, Vincent, NIGUIDULA, Nancy, IRELAND, Karen, SANTELLA, Regina M, ENG, Sybil M, TEITELBAUM, Susan L, BRITTON, Julie A, TERRY, Mary Beth, LEVIN, Bruce, STELLMAN, Steven D, KABAT, Geoffrey C

“…Whether environmental contaminants increase breast cancerrisk among women on Long Island, NY, is unknown. The study objective is to determine whether breast…”
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Variants in estrogen metabolism and biosynthesis genes and urinary estrogen metabolites in women with a family history of breast cancer by GREENLEE, Heather, YU CHEN, AHSAN, Habibul, KABAT, Geoffrey C, QIAO WANG, KIBRIYA, Muhammad G, GURVICH, Irina, SEPKOVIC, Daniel W, BRADLOW, H. Leon, SENIE, Ruby T, SANTELLA, Regina M

“…We examined associations between polymorphisms in genes related to estrogen metabolism (CYP1B1 codon 432G --> C rs#1056836, CYP1B1 codon 453A --> G rs#1800440,…”
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Evaluation of 3,3'-diindolylmethane with gardasil quadrivalent HPV vaccine in K14-HPV16-transgenic mice cervical histology by Sepkovic, Daniel W, Pagan, Doris V, Stein, Johann, Carlisle, Antoine D, Ksieski, H Barbara, Auborn, Karen, Nyirenda, Themba, Bradlow, H Leon

“…The effects of 3,3'-diindolylmethane (DIM) together with the Gardasil vaccine on cervical histology were evaluated using the K14-HPV16-transgenic mouse model…”
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Obesity and the gut microbiome: pathophysiological aspects by Bradlow, H Leon

“…While there is a large volume of literature describing a role for obesity as a risk factor for breast cancer and many other cancers, in the main a causal…”
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Physical Activity, Body Size, and Estrogen Metabolism in Women by Matthews, Charles E., Fowke, Jay H., Dai, Qi, Bradlow, H. Leon, Jin, Fan, Shu, Xiao-Ou, Gao, Yu-Tang, Longcope, Christopher, Hebert, James R., Zheng, Wei

“…Objectives: Physical activity has demonstrable effects on estrogen levels in pre- and postmenopausal women. Increased oxidation of estrone to 2-hydroxyestrone…”
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Indole-3-carbinol as a Chemoprotective Agent in Breast and Prostate Cancer by H. LEON BRADLOW

“…Assessment of the oral use of indole-3-carbinol (I3C) as a chemoprotective compound has not sufficiently considered the chemical instability of I3C. This…”
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Estrogen Hydroxylation-The Good and the Bad by Sepkovic, Daniel W., Bradlow, H. Leon

“…Although estradiol itself is primarily responsible for female development, the metabolites are responsible for many of the other positive and negative…”
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Urinary Estrogen Metabolites and Their Ratio among Asian American Women by FALK, Roni T, FEARS, Thomas R, BRADLOW, H. Leon, ZIEGLER, Regina G, XIA XU, HOOVER, Robert N, PIKE, Malcolm C, WU, Anna H, NOMURA, Abraham M. Y, KOLONEL, Laurence N, WEST, Dee W, SEPKOVIC, Daniel W

“…Controversy persists regarding the role of a low ratio of 2-hydroxyestone (2-OHE 1 )/16α-hydroxyestrone (16α-OHE 1 ) as a potential estrogen metabolism marker…”
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The nutritional herb Epimedium grandiflorum inhibits the growth in a model for the Luminal A molecular subtype of breast cancer by Telang, Nitin T, Li, Gou, Katdare, Meena, Sepkovic, Daniel W, Bradlow, H Leon, Wong, George Y C

“…The Luminal A subtype of breast cancer expresses the estrogen receptor (ER)-α and progesterone receptor (PR), but not the human epidermal growth factor…”
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Comparative Efficacy of Extracts from Lycium Barbarum Bark and Fruit on Estrogen Receptor Positive Human Mammary Carcinoma MCF-7 Cells by Telang, Nitin, Li, Gou, Sepkovic, Daniel, Bradlow, H. Leon, Wong, George Y. C

“…Chemo-endocrine therapy for estrogen receptor positive (ER ⁺) breast cancer exhibits acquired tumor resistance. Herbal medicines provide integrative support…”
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3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study by Rajoria, Shilpi, Suriano, Robert, Parmar, Perminder Singh, Wilson, Yushan Lisa, Megwalu, Uchechukwu, Moscatello, Augustine, Bradlow, H Leon, Sepkovic, Daniel W, Geliebter, Jan, Schantz, Stimson P, Tiwari, Raj K

“…The incidence of thyroid cancer is four to five times higher in women than in men, suggesting a role for estrogen (E₂) in the pathogenesis of thyroid…”
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The effect of oral 3,3′-diindolylmethane supplementation on the 2:16α-OHE ratio in BRCA1 mutation carriers by Nikitina, Dina, Llacuachaqui, Marcia, Sepkovic, Daniel, Bradlow, H. Leon, Narod, Steven A., Kotsopoulos, Joanne

“…Hormonal exposures are known to influence breast cancer risk among women with a BRCA1 mutation. Thus, dietary factors that increase the 2-hydroxyestrone…”
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Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking by Michnovicz, J J, Hershcopf, R J, Naganuma, H, Bradlow, H L, Fishman, J

“…Epidemiologic data indicate that cigarette smoking is associated with an important anti-estrogenic effect, and increased hepatic metabolism has been suggested…”
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Polychlorinated biphenyl exposure, diabetes and endogenous hormones: a cross-sectional study in men previously employed at a capacitor manufacturing plant by Persky, Victoria, Piorkowski, Julie, Turyk, Mary, Freels, Sally, Chatterton, Jr, Robert, Dimos, John, Bradlow, H Leon, Chary, Lin Kaatz, Burse, Virlyn, Unterman, Terry, Sepkovic, Daniel W, McCann, Kenneth

“…Studies have shown associations of diabetes and endogenous hormones with exposure to a wide variety of organochlorines. We have previously reported positive…”
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Estrogen Metabolism and Risk of Breast Cancer: A Prospective Study of the 2:16α-Hydroxyestrone Ratio in Premenopausal and Postmenopausal Women by Muti, Paola, Bradlow, H. Leon, Micheli, Andrea, Krogh, Vittorio, Freudenheim, Jo L., Schünemann, Holger J., Stanulla, Martin, Yang, Jun, Sepkovic, Daniel W., Trevisan, Maurizio, Berrino, Franco

“…Experimental and clinical evidence suggests that 16α-hydroxylated estrogen metabolites, biologically strong estrogens, are associated with breast cancer risk,…”
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The Long Island Breast Cancer Study project: Description of a multi-institutional collaboration to identify environmental risk factors for breast cancer by GAMMON, Marilie D, NEUGUT, Alfred I, LEVIN, Bruce, BRADLOW, H. Leon, HATCH, Maureen, BEYEA, Jan, CAMANN, David, TRENT, Martin, SENIE, Ruby T, GARBOWSKI, Gail C, MAFFEO, Carla, MONTALVAN, Pat, SANTELLA, Regina M, BERKOWITZ, Gertrud S, KEMENY, Margaret, CITRON, Marc, SCHNABEL, Freya, SCHUSS, Allan, HAJDU, Steven, VINCGUERRA, Vincent, COLLMAN, Gwen W, OBRAMS, G. Iris, TEITELBALUM, Susan L, BRITTON, Julie A, TERRY, Mary Beth, ENG, Sybil M, WOLFF, Mary S, STELLMAN, Steven D, KABAT, Geoffrey C

“…The Long Island Breast Cancer Study Project is a federally mandated, population-based case-control study to determine whether breast cancer risk among women in…”
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Lycium Barbarum Inhibits Growth of Estrogen Receptor Positive Human Breast Cancer Cells by Favorably Altering Estradiol Metabolism by Li, Go, Sepkovic, Daniel W, Bradlow, H. Leon, Telang, Nitin T, Wong, George Y.C

“…Selective estrogen receptor modulators represent accepted therapy for estrogen receptor positive (ER+) breast cancer, exhibit adverse side effects, and reduce…”
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