Search Results - "Bradley, Noah P."

Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts by Steenwyk, Jacob L, Opulente, Dana A, Kominek, Jacek, Shen, Xing-Xing, Zhou, Xiaofan, Labella, Abigail L, Bradley, Noah P, Eichman, Brandt F, Čadež, Neža, Libkind, Diego, DeVirgilio, Jeremy, Hulfachor, Amanda Beth, Kurtzman, Cletus P, Hittinger, Chris Todd, Rokas, Antonis

“…Cell-cycle checkpoints and DNA repair processes protect organisms from potentially lethal mutational damage. Compared to other budding yeasts in the subphylum…”
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Resistance-Guided Mining of Bacterial Genotoxins Defines a Family of DNA Glycosylases by Bradley, Noah P, Wahl, Katherine L, Steenwyk, Jacob L, Rokas, Antonis, Eichman, Brandt F

“…Unique DNA repair enzymes that provide self-resistance against therapeutically important, genotoxic natural products have been discovered in bacterial…”
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Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway by Mullins, Elwood A., Rodriguez, Alyssa A., Bradley, Noah P., Eichman, Brandt F.

“…The base excision repair (BER) pathway historically has been associated with maintaining genome integrity by eliminating nucleobases with small chemical…”
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Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance by Chen, Xiaorong, Bradley, Noah P, Lu, Wei, Wahl, Katherine L, Zhang, Mei, Yuan, Hua, Hou, Xian-Feng, Eichman, Brandt F, Tang, Gong-Li

“…Abstract Two families of DNA glycosylases (YtkR2/AlkD, AlkZ/YcaQ) have been found to remove bulky and crosslinking DNA adducts produced by bacterial natural…”
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A mechanistic model of primer synthesis from catalytic structures of DNA polymerase α–primase by Mullins, Elwood A., Salay, Lauren E., Durie, Clarissa L., Bradley, Noah P., Jackman, Jane E., Ohi, Melanie D., Chazin, Walter J., Eichman, Brandt F.

“…The mechanism by which polymerase α–primase (polα–primase) synthesizes chimeric RNA-DNA primers of defined length and composition, necessary for replication…”
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Structure of a DNA glycosylase that unhooks interstrand cross-links by Mullins, Elwood A., Warren, Garrett M., Bradley, Noah P., Eichman, Brandt F.

“…DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism…”
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Escherichia coli YcaQ is a DNA glycosylase that unhooks DNA interstrand crosslinks by Bradley, Noah P, Washburn, Lauren A, Christov, Plamen P, Watanabe, Coran M H, Eichman, Brandt F

“…Abstract Interstrand DNA crosslinks (ICLs) are a toxic form of DNA damage that block DNA replication and transcription by tethering the opposing strands of…”
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Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts by Steenwyk, Jacob L., Opulente, Dana A., Kominek, Jacek, Shen, Xing-Xing, Zhou, Xiaofan, Labella, Abigail L., Bradley, Noah P., Eichman, Brandt F., Čadež, Neža, Libkind, Diego, DeVirgilio, Jeremy, Hulfachor, Amanda Beth, Kurtzman, Cletus P., Hittinger, Chris Todd, Rokas, Antonis, Kamoun, Sophien

“…Cell-cycle checkpoints and DNA repair processes protect organisms from possibly lethal mutational damage. Compared to other budding yeasts in the subphylum…”
Get full text