Search Results - "Bradley, ME"

A common intracellular allosteric binding site for antagonists of the CXCR2 receptor by Salchow, K, Bond, ME, Evans, SC, Press, NJ, Charlton, SJ, Hunt, PA, Bradley, ME

“…Background and purpose:  We have previously shown that SB265610 (1‐(2‐bromo‐phenyl)‐3‐(7‐cyano‐3H‐benzotriazol‐4‐yl)‐urea) behaves as an allosteric, inverse…”
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SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor by Bradley, ME, Bond, ME, Manini, J, Brown, Z, Charlton, SJ

“…Background and purpose:  In several previous studies, the C‐X‐C chemokine receptor (CXCR)2 antagonist 1‐(2‐bromo‐phenyl)‐3‐(7‐cyano‐3H‐benzotriazol‐4‐yl)‐urea…”
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Prions Affect the Appearance of Other Prions: The Story of [PIN+] by Derkatch, Irina L, Bradley, Michael E, Hong, Joo Y, Liebman, Susan W

“…Prions are self-propagating protein conformations. Recent research brought insight into prion propagation, but how they first appear is unknown. We previously…”
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Ertel potential vorticity versus Bernoulli streamfunction on Mars by Dowling, T. E., Bradley, M. E., Du, J., Lewis, S. R., Read, P. L.

“…Scatter plots of Ertel potential vorticity, Q, versus Bernoulli streamfunction, B, on potential temperature surfaces, θ, are investigated for Mars using the…”
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Interactions among Prions and Prion "Strains" in Yeast by Bradley, Michael E., Edskes, Herman K., Hong, Joo Y., Wickner, Reed B., Liebman, Susan W.

“…Prions are "infectious" proteins. When Sup35, a yeast translation termination factor, is aggregated in its [PSI+]prion form its function is compromised. When…”
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Using 3D finite volume for the pressure-gradient force in atmospheric models by Bradley, M. E., Dowling, T. E.

“…The horizontal pressure‐gradient force is traditionally discretized in partial‐differential equation (PDE) form in atmospheric models, but may alternatively be…”
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Destabilizing Interactions Among [PSI+] and [PIN+] Yeast Prion Variants by Bradley, Michael E, Liebman, Susan W

“…The yeast Sup35 and Rnq1 proteins can exist in either the noninfectious soluble forms, [psi-] or [pin-], respectively, or the multiple infectious amyloid-like…”
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Ertel potential vorticity versus Bernoulli streamfunction in earth's extratropical atmosphere by Du, J., Dowling, T. E., Bradley, M. E.

“…We investigate the correlation of Ertel potential vorticity, Q, with Bernoulli streamfunction, B, on potential‐temperature surfaces, θ, in Earth's atmosphere…”
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The Sup35 domains required for maintenance of weak, strong or undifferentiated yeast [PSI+] prions by Bradley, Michael E., Liebman, Susan W.

“…Summary The Sup35 protein can exist in a non‐infectious form or in various infectious forms called [PSI+] prion variants (or prion strains). Each of the…”
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Genetic and Environmental Factors Affecting the de novo Appearance of the [PSI(+)] Prion in Saccharomyces cerevisiae by Derkatch, I. L, Bradley, M. E, Zhou, P, Chernoff, Y. O, Liebman, S. W

“…It has previously been shown that yeast prion [PSI+] is cured by GuHCl, although reports on reversibility of curing were contradictory. Here we show that GuHCl…”
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Dependence and independence of [PSI+] and [PIN+]: a two-prion system in yeast? by Derkatch, I.L, Bradley, M.E, Masse, S.V.L, Zadorsky, S.P, Polozkov, G.V, Inge-Vechtomov, S.G, Liebman, S.W

“…The [PSI+] prion can be induced by overproduction of the complete Sup35 protein, but only in strains carrying the non‐Mendelian [PIN+] determinant. Here we…”
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The EPIC atmospheric model with an isentropic/terrain-following hybrid vertical coordinate by Dowling, Timothy E., Bradley, Mary E., Colón, Edward, Kramer, John, LeBeau, Raymond P., Lee, Grace C.H., Mattox, Timothy I., Morales-Juberías, Raul, Palotai, Csaba J., Parimi, Vimal K., Showman, Adam P.

“…The explicit planetary isentropic coordinate (EPIC) atmospheric model has been upgraded to use a hybrid vertical coordinate, ζ, that transitions continuously…”
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Contingency analysis of operational planning models with distribution network reconfiguration by Shahriar Muttalib, A. Z. M., Taylor, G. A., Bradley, M. E.

“…This paper presents a new load curve methodology based on an enhancement of the Extended Ward equivalent for offline contingency analysis in GB transmission…”
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Bilinear Optimal Control of the Velocity Term in a Kirchhoff Plate Equation by Bradley, Mary Elizabeth, Lenhart, Suzanne, Yong, Jiongmin

“…We consider a bilinear optimal control problem where the state equation is a Kirchhoff plate equation. The control acts as a multiplier of the velocity term…”
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A performance-index guided continuation method for fast computation of saddle-node bifurcation in power systems by Ke Chen, Hussein, A., Bradley, M.E., Wan, H.

“…Simple performance indices for detecting and predicting stability problems such as the voltage collapse are useful analysis tools for planning and operating…”
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Guanidine reduces stop codon read‐through caused by missense mutations in SUP35 or SUP45 by Bradley, Michael E., Bagriantsev, Sviatoslav, Vishveshwara, Namitha, Liebman, Susan W.

“…Sup35 and Sup45 are essential protein components of the Saccharomyces cerevisiae translation termination factor. Yeast cells harbouring the [PSI+] prion form…”
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Nitric oxide relaxes human myometrium by a cGMP-independent mechanism by Bradley, K K, Buxton, I L, Barber, J E, McGaw, T, Bradley, M E

“…The role of intracellular guanosine 3',5'-cyclic monophosphate concentration ([cGMP]i) in nitric oxide (NO)-mediated relaxations in the uterus has become…”
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Chemotactic, mitogenic, and angiogenic actions of UTP on vascular endothelial cells by Satterwhite, C M, Farrelly, A M, Bradley, M E

“…Endothelial cells express receptors for ATP and UTP, and both UTP and ATP elicit endothelial release of vasoactive compounds such as prostacyclin and nitric…”
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Purine nucleoside-dependent inhibition of cellular proliferation in 1321N1 human astrocytoma cells by Bradley, K K, Bradley, M E

“…We examined the effects of purines and the pyrimidine UTP on cellular proliferation in the human astrocytoma cell line 1321N1. Treatment of cultured cells with…”
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Proteolytic Regulation of the Zinc Finger Transcription Factor YY1, a Repressor of Muscle-restricted Gene Expression by Walowitz, J L, Bradley, M E, Chen, S, Lee, T

“…Regulated proteolysis has been postulated to be critical for proper control of cell functions. Muscle development, in particular, involves a great deal of…”
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