Search Results - "Bradley, John R."

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission by Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P

“…Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening…”
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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling by Hurst, Liam A., Dunmore, Benjamin J., Long, Lu, Crosby, Alexi, Al-Lamki, Rafia, Deighton, John, Southwood, Mark, Yang, Xudong, Nikolic, Marko Z., Herrera, Blanca, Inman, Gareth J., Bradley, John R., Rana, Amer A., Upton, Paul D., Morrell, Nicholas W.

“…Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH)…”
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Mechanisms of endothelial dysfunction, injury, and death by Pober, Jordan S, Min, Wang, Bradley, John R

“…Vascular endothelial cells normally perform several key homeostatic functions such as keeping blood fluid, regulating blood flow, regulating macromolecule and…”
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Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity by Potts, Martin, Fletcher-Etherington, Alice, Nightingale, Katie, Mescia, Federica, Bergamaschi, Laura, Calero-Nieto, Fernando J., Antrobus, Robin, Williamson, James, Parsons, Harriet, Huttlin, Edward L., Kingston, Nathalie, Göttgens, Berthold, Bradley, John R., Lehner, Paul J., Matheson, Nicholas J., Smith, Kenneth G.C., Wills, Mark R., Lyons, Paul A., Weekes, Michael P.

“…Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2…”
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Tumor necrosis factor receptor-associated factors (TRAFs) by Bradley, J R, Pober, J S

“…Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as adaptor proteins that couple the tumor necrosis factor receptor family…”
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Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD20 therapy by Priddey, Ashley, Chen-Xu, Michael Xin Hua, Cooper, Daniel James, MacMillan, Serena, Meisl, Georg, Xu, Catherine K, Hosmillo, Myra, Goodfellow, Ian G, Kollyfas, Rafael, Doffinger, Rainer, Bradley, John R, Mohorianu, Irina I, Jones, Rachel, Knowles, Tuomas P J, Smith, Rona, Kosmoliaptsis, Vasilis

“…Patients with autoimmune/inflammatory conditions on anti-CD20 therapies, such as rituximab, have suboptimal humoral responses to vaccination and are vulnerable…”
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Effect of kidney donation on bone mineral metabolism by Hiemstra, Thomas F, Smith, Jane C, Lim, Kenneth, Xu, Dihua, Kulkarni, Shreya, Bradley, J Andrew, Paapstel, Kaido, Schoenmakers, Inez, Bradley, John R, Tomlinson, Laurie, McEniery, Carmel M, Wilkinson, Ian B

“…Kidney donation results in reductions in kidney function and lasting perturbations in phosphate homeostasis, which may lead to adverse cardiovascular sequelae…”
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Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID by Krishna, Benjamin A, Lim, Eleanor Y, Mactavous, Lenette, Lyons, Paul A, Doffinger, Rainer, Bradley, John R, Smith, Kenneth G C, Sinclair, John, Matheson, Nicholas J, Lehner, Paul J, Wills, Mark R, Sithole, Nyaradzai

“…There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded…”
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Evaluation of interventions to prevent vasovagal reactions among whole blood donors: rationale and design of a large cluster randomised trial by McMahon, Amy, Kaptoge, Stephen, Walker, Matthew, Mehenny, Susan, Gilchrist, Philippe T, Sambrook, Jennifer, Akhtar, Naim, Sweeting, Michael, Wood, Angela M, Stirrups, Kathleen, Chung, Ryan, Fahle, Sarah, Johnson, Elisha, Cullen, Donna, Godfrey, Rosemary, Duthie, Shannon, Allen, Louise, Harvey, Paul, Berkson, Michael, Allen, Elizabeth, Watkins, Nicholas A, Bradley, John R, Kingston, Nathalie, Miflin, Gail, Armitage, Jane, Roberts, David J, Danesh, John, Di Angelantonio, Emanuele

“…Vasovagal reactions (VVRs) are the most common acute complications of blood donation. Responsible for substantial morbidity, they also reduce the likelihood of…”
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The impact of hypoxia on B cells in COVID-19 by Kotagiri, Prasanti, Mescia, Federica, Hanson, Aimee L., Turner, Lorinda, Bergamaschi, Laura, Peñalver, Ana, Richoz, Nathan, Moore, Stephen D., Ortmann, Brian M., Dunmore, Benjamin J., Morgan, Michael D., Tuong, Zewen Kelvin, Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Maxwell, Patrick. H., Clatworthy, Menna. R., Nathan, James A., Bradley, John R., Lyons, Paul A., Burrows, Natalie, Smith, Kenneth G.C.

“…Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence…”
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Human Organ Culture: Updating the Approach to Bridge the Gap from In Vitro to In Vivo in Inflammation, Cancer, and Stem Cell Biology by Al-Lamki, Rafia S, Bradley, John R, Pober, Jordan S

“…Human studies, critical for developing new diagnostics and therapeutics, are limited by ethical and logistical issues, and preclinical animal studies are often…”
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Using machine learning to model older adult inpatient trajectories from electronic health records data by Herrero-Zazo, Maria, Fitzgerald, Tomas, Taylor, Vince, Street, Helen, Chaudhry, Afzal N., Bradley, John R., Birney, Ewan, Keevil, Victoria L.

“…Electronic Health Records (EHR) data can provide novel insights into inpatient trajectories. Blood tests and vital signs from de-identified patients’ hospital…”
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Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study by Tsvetanov, Kamen A., Spindler, Lennart R.B., Stamatakis, Emmanuel A., Newcombe, Virginia F.J., Lupson, Victoria C., Chatfield, Doris A., Manktelow, Anne E., Outtrim, Joanne G., Elmer, Anne, Kingston, Nathalie, Bradley, John R., Bullmore, Edward T., Rowe, James B., Menon, David K.

“…•Chronic cerebrovascular dysfunction (CVD) was related to the severity of acute COVID-19.•This relationship was not explained by other COVID-19 risk factors or…”
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TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury by Al-Lamki, Rafia S, Wang, Jun, Vandenabeele, Peter, Bradley, J. Andrew, Thiru, Sathia, Luo, Dianghong, Min, Wang, Pober, Jordan S, Bradley, John R

“…In normal kidney, TNFR1 is expressed in glomerular and peritubular capillary EC, and some tubular cells, and colocalizes with inactive apoptosis…”
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Tumor necrosis factor receptor‐2 signaling pathways promote survival of cancer stem‐like CD133+ cells in clear cell renal carcinoma by Bradley, John R., Wang, Jun, Pacey, Simon, Warren, Anne Y., Pober, Jordan S., Al‐Lamki, Rafia S.

“…Clear cell renal cell carcinoma (ccRCC) contains cancer stem‐like cells (CSCs) that express CD133 (ccRCC‐CD133+). CSCs are rarely in cell cycle and, as…”
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Caveolae Participate in Tumor Necrosis Factor Receptor 1 Signaling and Internalization in a Human Endothelial Cell Line by D'Alessio, Alessio, Al-Lamki, Rafia S., Bradley, John R., Pober, Jordan S.

“…Caveolae are abundant in endothelial cells (ECs) in situ but markedly diminished in cultured cells, making it difficult to assess their role in cytokine…”
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Tumour necrosis factor and cancer by Waters, John P, Pober, Jordan S, Bradley, John R

“…Tumour necrosis factor (TNF) was originally described as a circulating factor that can induce haemorrhagic necrosis of tumours. It is now clear that TNF has…”
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Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19 by Wang, Jun, Kotagiri, Prasanti, Lyons, Paul A., Al-Lamki, Rafia S., Mescia, Federica, Bergamaschi, Laura, Turner, Lorinda, Morgan, Michael D., Calero-Nieto, Fernando J., Bach, Karsten, Mende, Nicole, Wilson, Nicola K., Watts, Emily R., Maxwell, Patrick H., Chinnery, Patrick F., Kingston, Nathalie, Papadia, Sofia, Stirrups, Kathleen E., Walker, Neil, Gupta, Ravindra K., Menon, David K., Allinson, Kieren, Aitken, Sarah J., Toshner, Mark, Weekes, Michael P., Nathan, James A., Walmsley, Sarah R., Ouwehand, Willem H., Kasanicki, Mary, Göttgens, Berthold, Marioni, John C., Smith, Kenneth G.C., Pober, Jordan S., Bradley, John R.

“…Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq…”
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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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The Efficacy of Sunitinib Treatment of Renal Cancer Cells Is Associated with the Protein PHAX In Vitro by Al-Lamki, Rafia S, Hudson, Nicholas J, Bradley, John R, Warren, Anne Y, Eisen, Tim, Welsh, Sarah J, Riddick, Antony C P, O'Mahony, Fiach C, Turnbull, Arran, Powles, Thomas, Scotrrcc Collaborative, Reverter, Antonio, Harrison, David J, Stewart, Grant D

“…Anti-angiogenic agents, such as the multi-tyrosine kinase inhibitor sunitinib, are key first line therapies for metastatic clear cell renal cell carcinoma…”
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