Search Results - "Bradley, John M"

Mapping molecular differences and extracellular matrix gene expression in segmental outflow pathways of the human ocular trabecular meshwork by Vranka, Janice A, Bradley, John M, Yang, Yong-Feng, Keller, Kate E, Acott, Ted S

“…Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, and lowering IOP remains the only effective treatment for glaucoma. The trabecular…”
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Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover by Aga, Mini, Bradley, John M, Keller, Kate E, Kelley, Mary J, Acott, Ted S

“…There are distinctive areas of colocalization of matrix metalloproteinase (MMP)-2 and -14 on trabecular meshwork (TM) cells that resemble podosomes or…”
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Synergism of TNF and IL-1 in the Induction of Matrix Metalloproteinase-3 in Trabecular Meshwork by Kelley, Mary J, Rose, Anastasia Y, Song, Kaili, Chen, Yanwen, Bradley, John M, Rookhuizen, Derek, Acott, Ted S

“…TNF and IL-1 increase matrix metalloproteinase-3 (MMP-3) expression in the trabecular meshwork (TM). TNF-alpha, in combination with IL-1alpha or IL-1beta,…”
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Signaling Pathways Used in Trabecular Matrix Metalloproteinase Response to Mechanical Stretch by Bradley, John M. B, Kelley, Mary J, Rose, Anastasia, Acott, Ted S

“…Trabecular meshwork (TM) matrix metalloproteinase (MMP), and tissue inhibitor (TIMP) changes in response to mechanical stretching appear to be central to…”
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Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells by Sun, Ying Ying, Bradley, John M, Keller, Kate E

“…Trabecular meshwork (TM) cells detect and coordinate responses to intraocular pressure (IOP) in the eye. TM cells become dysfunctional in glaucoma where IOP is…”
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Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells by Keller, Kate E, Bradley, John M, Sun, Ying Ying, Yang, Yong-Feng, Acott, Ted S

“…The actin cytoskeleton of trabecular meshwork (TM) cells plays a role in regulating aqueous humor outflow. Many studies have investigated stress fibers, but…”
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Segmental versican expression in the trabecular meshwork and involvement in outflow facility by Keller, Kate E, Bradley, John M, Vranka, Janice A, Acott, Ted S

“…Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. To assess versican's potential…”
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Extracellular matrix turnover and outflow resistance by Keller, Kate E., Aga, Mini, Bradley, John M., Kelley, Mary J., Acott, Ted S.

“…Normal homeostatic adjustment of elevated intraocular pressure (IOP) involves remodeling the extracellular matrix (ECM) of the trabecular meshwork (TM). This…”
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Differential effects of caveolin-1 and -2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells by Aga, Mini, Bradley, John M, Wanchu, Rohan, Yang, Yong-feng, Acott, Ted S, Keller, Kate E

“…A single nucleotide polymorphism (SNP) identified between caveolin-1 (CAV1) and caveolin-2 (CAV2) on chromosome 7 is associated with glaucoma. One function of…”
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Intraocular pressure homeostasis: maintaining balance in a high-pressure environment by Acott, Ted S, Kelley, Mary J, Keller, Kate E, Vranka, Janice A, Abu-Hassan, Diala W, Li, Xinbo, Aga, Mini, Bradley, John M

“…Although glaucoma is a relatively common blinding disease, most people do not develop glaucoma. A robust intraocular pressure (IOP) homeostatic mechanism keeps…”
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Differential Effects of ADAMTS-1, -4, and -5 in the Trabecular Meshwork by Keller, Kate E, Bradley, John M, Acott, Ted S

“…Matrix metalloproteinases (MMPs) degrade extracellular matrix (ECM) and increase outflow facility in anterior segment perfusion culture. One group is the…”
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Effects of Modifiers of Glycosaminoglycan Biosynthesis on Outflow Facility in Perfusion Culture by Keller, Kate E, Bradley, John M, Kelley, Mary J, Acott, Ted S

“…Glycosaminoglycans (GAGs) have been implicated in the regulation of outflow resistance of aqueous humor flow through the trabecular meshwork (TM). Their role…”
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Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility by Keller, Kate E, Sun, Ying Ying, Yang, Yong-Feng, Bradley, John M, Acott, Ted S

“…Hyaluronan (HA) is a major component of the aqueous outflow pathway. However, the contribution of HA to human outflow resistance remains unclear. Three HA…”
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Molecular chaperone function for myocilin by Anderssohn, Ann Marie, Cox, Kalani, O'Malley, Kevin, Dees, Scott, Hosseini, Mojgan, Boren, Lacey, Wagner, Anthony, Bradley, John M, Kelley, Mary J, Acott, Ted S

“…Myocilin is thought to be a stress response protein, but its exact molecular functions have not been established. Studies were conducted to see whether…”
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Early changes in matrix metalloproteinases and inhibitors after in vitro laser treatment to the trabecular meshwork by Parshley, D E, Bradley, J M, Samples, J R, Van Buskirk, E M, Acott, T S

“…Extracellular matrix turnover in the trabecular meshwork may play a role in regulating aqueous humor outflow. Laser trabeculoplasty is a common treatment for…”
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Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial by Burmester, Gerd R, Prof, Blanco, Ricardo, MD, Charles-Schoeman, Christina, MD, Wollenhaupt, Jürgen, Prof, Zerbini, Cristiano, MD, Benda, Birgitta, MD, Gruben, David, PhD, Wallenstein, Gene, PhD, Krishnaswami, Sriram, PhD, Zwillich, Samuel H, MD, Koncz, Tamas, MD, Soma, Koshika, MD, Bradley, John, MD, Mebus, Charles, PhD

“…Summary Background Rheumatoid arthritis is a heterogeneous chronic disease, and no therapeutic agent has been identified which is universally and persistently…”
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Case Studies in Support of Multiple Criteria for Developmental Reading Placement by Shelor, Mary D., Bradley, John M.

“…Three incoming first-year community college students were advised into developmental reading courses because of low scores on the Nelson Denny Reading Test…”
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Effects of Mechanical Stretching on Trabecular Matrix Metalloproteinases by Bradley, John M. B, Kelley, Mary J, Zhu, XiangHong, Anderssohn, Ann Marie, Alexander, J. Preston, Acott, Ted S

“…The homeostatic mechanisms responsible for intraocular pressure (IOP) regulation are not understood. Studies were conducted to evaluate the hypothesis that…”
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Mapping Molecular Differences and Extracellular Matrix Gene Expression in Segmental Outflow Pathways of the Human Ocular Trabecular Meshwork: e0122483 by Vranka, Janice A, Bradley, John M, Yang, Yong-Feng, Keller, Kate E, Acott, Ted S

“…Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, and lowering IOP remains the only effective treatment for glaucoma. The trabecular…”
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Effects of Proofreading on Spelling: How Reading Misspelled and Correctly Spelled Words Affects Spelling Accuracy by Bradley, John M, King, Priscilla Vacca

“…Finds that (1) exposure to correctly spelled words improved spelling accuracy for immediate and delayed posttests; (2) exposure to misspelled words did not…”
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