Search Results - "Bradley, John E."

The establishment of resident memory B cells in the lung requires local antigen encounter by Allie, S. Rameeza, Bradley, John E., Mudunuru, Uma, Schultz, Michael D., Graf, Beth A., Lund, Frances E., Randall, Troy D.

“…Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may be tissue-resident cells. Here we show that pulmonary influenza…”
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge by King, R Glenn, Silva-Sanchez, Aaron, Peel, Jessica N, Botta, Davide, Dickson, Alexandria M, Pinto, Amelia K, Meza-Perez, Selene, Allie, S Rameeza, Schultz, Michael D, Liu, Mingyong, Bradley, John E, Qiu, Shihong, Yang, Guang, Zhou, Fen, Zumaquero, Esther, Simpler, Thomas S, Mousseau, Betty, Killian, Jr, John T, Dean, Brittany, Shang, Qiao, Tipper, Jennifer L, Risley, Christopher A, Harrod, Kevin S, Feng, Tsungwei, Lee, Young, Shiberu, Bethlehem, Krishnan, Vyjayanthi, Peguillet, Isabelle, Zhang, Jianfeng, Green, Todd J, Randall, Troy D, Suschak, John J, Georges, Bertrand, Brien, James D, Lund, Frances E, Roberts, M Scot

“…The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for effective prophylactic vaccination to prevent the spread of severe acute…”
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Chitinase-3-like 1 regulates TH2 cells, TFH cells and IgE responses to helminth infection by Curtiss, Miranda L., Rosenberg, Alexander F., Scharer, Christopher D., Mousseau, Betty, Benavides, Natalia A. Ballesteros, Bradley, John E., León, Beatriz, Steele, Chad, Randall, Troy D., Lund, Frances E.

“…Introduction Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein…”
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Roles and regulation of Thy-1, a context-dependent modulator of cell phenotype by Bradley, John E., Ramirez, Gustavo, Hagood, James S.

“…Thy‐1 or CD90 is a glycophosphatidylinositol‐linked glycoprotein expressed on the surface of neurons, thymocytes, subsets of fibroblasts, endothelial cells,…”
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Effect of the GPI anchor of human Thy-1 on antibody recognition and function by Bradley, John E, Chan, Joy M, Hagood, James S

“…Thymocyte differentiation antigen-1 (Thy-1) is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein expressed on numerous cell types, which…”
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FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability by León, Beatriz, Bradley, John E., Lund, Frances E., Randall, Troy D., Ballesteros-Tato, André

“…Here, we test the role of FoxP3 + regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza…”
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EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production by Guo, Muyao, Price, Madeline J, Patterson, Dillon G, Barwick, Benjamin G, Haines, Robert R, Kania, Anna K, Bradley, John E, Randall, Troy D, Boss, Jeremy M, Scharer, Christopher D

“…Epigenetic remodeling is required during B cell differentiation. However, little is known about the direct functions of epigenetic enzymes in Ab-secreting…”
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A transcriptionally distinct subset of influenza-specific effector memory B cells predicts long-lived antibody responses to vaccination in humans by Nellore, Anoma, Zumaquero, Esther, Scharer, Christopher D., Fucile, Christopher F., Tipton, Christopher M., King, R. Glenn, Mi, Tian, Mousseau, Betty, Bradley, John E., Zhou, Fen, Mutneja, Stuti, Goepfert, Paul A., Boss, Jeremy M., Randall, Troy D., Sanz, Ignacio, Rosenberg, Alexander F., Lund, Frances E.

“…Seasonal influenza vaccination elicits hemagglutinin (HA)-specific memory B (Bmem) cells, and although multiple Bmem cell populations have been characterized,…”
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IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes by Price, Madeline J, Hicks, Sakeenah L, Bradley, John E, Randall, Troy D, Boss, Jeremy M, Scharer, Christopher D

“…Ab-secreting cells (ASC) or plasma cells are essential components of the humoral immune system. Although Abs of different isotypes have distinct functions, it…”
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Antigen-Specific CD4 T Cell and B Cell Responses to Borrelia burgdorferi by Hammond, Elizabeth M, Olsen, Kimberly J, Ram, Shivneel, Tran, Giang Vu Vi, Hall, Laura S, Bradley, John E, Lund, Frances E, Samuels, D Scott, Baumgarth, Nicole

“…Long-lived T-dependent B cell responses fail to develop during persistent infection of mice with Borrelia burgdorferi, the causative agent of Lyme disease,…”
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Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution by Liu, Xiaoqiu, Wong, Simon S, Taype, Carmen A, Kim, Jeeyeon, Shentu, Tzu-Pin, Espinoza, Celia R, Finley, J Cameron, Bradley, John E, Head, Brian P, Patel, Hemal H, Mah, Emma J, Hagood, James S

“…Thy-1-negative lung fibroblasts are resistant to apoptosis. The mechanisms governing this process and its relevance to fibrotic remodeling remain poorly…”
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General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice by Hamilton, Jennie A, Li, Jun, Wu, Qi, Yang, PingAr, Luo, Bao, Li, Hao, Bradley, John E, Taylor, Justin J, Randall, Troy D, Mountz, John D, Hsu, Hui-Chen

“…Autoreactive B cells are associated with the development of several autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. The…”
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ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells by Panneton, Vincent, Mindt, Barbara C, Bouklouch, Yasser, Bouchard, Antoine, Mohammaei, Saba, Chang, Jinsam, Diamantopoulos, Nikoletta, Witalis, Mariko, Li, Joanna, Stancescu, Albert, Bradley, John E, Randall, Troy D, Fritz, Jörg H, Suh, Woong-Kyung

“…ICOS is a T-cell costimulatory receptor critical for Tfh cell generation and function. However, the role of ICOS in Tfr cell differentiation remains unclear…”
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IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation by Zumaquero, Esther, Stone, Sara L, Scharer, Christopher D, Jenks, Scott A, Nellore, Anoma, Mousseau, Betty, Rosal-Vela, Antonio, Botta, Davide, Bradley, John E, Wojciechowski, Wojciech, Ptacek, Travis, Danila, Maria I, Edberg, Jeffrey C, Bridges, S Louis, Kimberly, Robert P, Chatham, W Winn, Schoeb, Trenton R, Rosenberg, Alexander F, Boss, Jeremy M, Sanz, Ignacio, Lund, Frances E

“…Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse…”
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Redistribution of T follicular helper cells to the lungs of neonatal mice infected with influenza by Fuller, Michael John, Bradley, John E., Randall, Troy D

“…Abstract The infant immune system responds poorly to both infection and vaccination, however the mechanisms responsible for impaired immune responses in…”
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Identification of antigen-specific, lung resident memory B cells after influenza infection by Allie, S Rameeza, Bradley, John E, Mudunuru, Uma, Randall, Troy D.

“…Abstract B cells display phenotypic and functional heterogeneity in multiple anatomical locations following vaccination or infection. Influenza-specific memory…”
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The LFA1 ligand, CD54, is not required for the differentiation of TFH cells or germinal center formation by Bowlin, Marvin Q, Bradley, John E, Zajac, Allan J, Bullard, Daniel C, Randall, Troy D

“…Abstract In germinal centers (GC), B cells undergo cellular proliferation and affinity maturation, and ultimately differentiate into either high-affinity…”
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Dynamic regulation of T Follicular Regulatory (Tfr) cell responses by Interleukin-2 (IL-2) during influenza infection by Ballesteros-Tato, Andre, Botta, Davide, Fuller, Michael J, Bachus, Holly, Bradley, John E, Zajac, Allan J, Randall, Troy D, Lund, Frances E, Ruiz, Beatriz León

“…Abstract IL-2 promotes FoxP3+ regulatory T (Treg) cell responses, but inhibits the differentiation of T follicular helper (Tfh) cells. However, it is not clear…”
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Chitinase-3-like 1 regulates T H 2 cells, T FH cells and IgE responses to helminth infection by Curtiss, Miranda L, Rosenberg, Alexander F, Scharer, Christopher D, Mousseau, Betty, Benavides, Natalia A Ballesteros, Bradley, John E, León, Beatriz, Steele, Chad, Randall, Troy D, Lund, Frances E

“…Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in…”
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