Search Results - "Bradley, Jessica M"

Garlic-Derived Organic Polysulfides and Myocardial Protection by Bradley, Jessica M, Organ, Chelsea L, Lefer, David J

“…For centuries, garlic has been shown to exert substantial medicinal effects and is considered to be one of the best disease-preventative foods. Diet is…”
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Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent by King, Adrienne L., Polhemus, David J., Bhushan, Shashi, Otsuka, Hiroyuki, Kondo, Kazuhisa, Nicholson, Chad K., Bradley, Jessica M., Islam, Kazi N., Calvert, John W., Tao, Ya-Xiong, Dugas, Tammy R., Kelley, Eric E., Elrod, John W., Huang, Paul L., Wang, Rui, Lefer, David J.

“…Previous studies have demonstrated that hydrogen sulfide (H ₂S) protects against multiple cardiovascular disease states in a similar manner as nitric oxide…”
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Integrating physiology into the first two years of a new osteopathic medical school curriculum by Slater, Natalie F., Nizamutdinova, Irina, Jacobs, Blaine A., Slater, Robert T., Bradley, Jessica M.

“…The integrated curriculum is a hot topic in curriculum reform in undergraduate medical education; however, there are varying definitions of the term, and…”
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A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure by Bradley, Jessica M, Li, Zhen, Organ, Chelsea L, Polhemus, David J, Otsuka, Hiroyuki, Islam, Kazi N, Bhushan, Shashi, Gorodnya, Olena M, Ruchko, Mykhaylo V, Gillespie, Mark N, Wilson, Glenn L, Lefer, David J

“…Oxidative stress results in mtDNA damage and contributes to myocardial cell death. mtDNA repair enzymes are crucial for mtDNA repair and cell survival. We…”
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Nitrite Therapy Ameliorates Myocardial Dysfunction via H2S and Nuclear Factor‐Erythroid 2‐Related Factor 2 (Nrf2)‐Dependent Signaling in Chronic Heart Failure by Donnarumma, Erminia, Bhushan, Shashi, Bradley, Jessica M., Otsuka, Hiroyuki, Donnelly, Erinn L., Lefer, David J., Islam, Kazi N.

“…Background Bioavailability of nitric oxide (NO) and hydrogen sulfide (H2S) is reduced in heart failure (HF). Recent studies suggest cross‐talk between NO and…”
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Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability by Donnarumma, Erminia, Ali, Murtuza J., Rushing, Amanda M., Scarborough, Amy L., Bradley, Jessica M., Organ, Chelsea L., Islam, Kazi N., Polhemus, David J., Evangelista, Stefano, Cirino, Giuseppe, Jenkins, J. Stephen, Patel, Rajan A. G., Lefer, David J., Goodchild, Traci T.

“…Background Zofenopril, a sulfhydrylated angiotensin‐converting enzyme inhibitor (ACEI), reduces mortality and morbidity in infarcted patients to a greater…”
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Detrimental role of lysyl oxidase in cardiac remodeling by El Hajj, Elia C., El Hajj, Milad C., Ninh, Van K., Bradley, Jessica M., Claudino, Mario A., Gardner, Jason D.

“…A key feature of heart failure is adverse extracellular matrix (ECM) remodeling, which is associated with increases in the collagen cross-linking enzyme, lysyl…”
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A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure by Bradley, Jessica M, Spaletra, Pablo, Li, Zhen, Sharp, 3rd, Thomas E, Goodchild, Traci T, Corral, Laura G, Fung, Leah, Chan, Kyle W H, Sullivan, Robert W, Swindlehurst, Cathy A, Lefer, David J

“…Cardiac fibroblasts are critical mediators of fibrotic remodeling in the failing heart and transform into myofibroblasts in the presence of profibrotic factors…”
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Estrogen attenuates chronic volume overload induced structural and functional remodeling in male rat hearts by Gardner, Jason D, Murray, David B, Voloshenyuk, Tetyana G, Brower, Gregory L, Bradley, Jessica M, Janicki, Joseph S

“…We have previously reported gender differences in ventricular remodeling and development of heart failure using the aortocaval fistula model of chronic volume…”
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Exposure to diesel exhaust particulates induces cardiac dysfunction and remodeling by Bradley, Jessica M, Cryar, Kipp A, El Hajj, Milad C, El Hajj, Elia C, Gardner, Jason D

“…Chronic exposure to diesel exhaust particulates (DEP) increases the risk of cardiovascular disease in urban residents, predisposing them to the development of…”
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Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome by Polhemus, David J, Bradley, Jessica M, Islam, Kazi N, Brewster, Luke P, Calvert, John W, Tao, Ya-Xiong, Chang, Carlos C, Pipinos, Iraklis I, Goodchild, Traci T, Lefer, David J

“…Nitrite is a storage reservoir of nitric oxide that is readily reduced to nitric oxide under pathological conditions. Previous studies have demonstrated that…”
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Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease by Bradley, Jessica M, Islam, Kazi N, Polhemus, David J, Donnarumma, Erminia, Brewster, Luke P, Tao, Ya-Xiong, Goodchild, Traci T, Lefer, David J

“…Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting vascular…”
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RENAL DENERVATION IMPROVES POST-INFARCTION REMODELING AND HEMODYNAMICS THROUGH MODULATION OF CARDIOPROTECTIVE PLASMA PEPTIDES by Polhemus, David, Gao, Juan, Scarborough, Amy L, Bradley, Jessica M, Trivedi, Rishi K, Smart, Frank, Kapusta, Daniel R, Lefer, David J

“…Methods Spontaneously hypertensive rats (SHR) were subjected to 45 min. of coronary artery ligation and reperfusion (Rep) for 12 weeks…”
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TCT-434 Vascular Protective Actions Of A Novel Sustained Release Nitrite Formulation In Obese Swine With Metabolic Syndrome by Bradley, Jessica M, Goodchild, Traci T, Polhemus, David J, Chang, Carlos C, Giordano, Tony, Lefer, David J

“…Background Nitrite is a physiologically important nitric oxide (NO) storage intermediate that is reduced to NO during cardiovascular disease states and serves…”
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TCT-523 Therapeutic Potential Of Sustained Release Sodium Nitrite For Critical Limb Ischemia In The Setting Of Metabolic Syndrome by Goodchild, Traci T, Polhemus, David J, Bradley, Jessica M, Chang, Carlos C, Islam, Kazi N, Giordano, Tony, Lefer, David J

“…Analysis of VEGF and markers for endothelial cell proliferation (CD31 and vWF) revealed that SR-Nitrite promoted angiogenic signaling in the ischemic limb…”
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Cigarette smoke exacerbates ventricular remodeling and dysfunction in the volume overloaded heart by Bradley, Jessica M, Nguyen, Jonathan B, Fournett, Alyssa C, Gardner, Jason D

“…Cigarette smoking is an independent risk factor for heart disease and is linked to sudden cardiac death. In this study, we examined the effects of cigarette…”
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A Case Study of the Relationship Between Higher Education Financial Health, Student Experience, and Student Success Among Public Institutions in the South by Bradley, Jessica M

“…How are finances impacted in the higher education environment? How are students currently experiencing college? How are higher education leaders putting forth…”
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Abstract 15511: A Novel Mitochondrial Targeted DNA Repair Enzyme Attenuates Maladaptive Myocardial Remodeling and Preserves Cardiac Function in Heart Failure by Bradley, Jessica M, Otsuka, Hiroyuki, Organ, Chelsea L, Bhushan, Shashi, Polhemus, David J, Wilson, Glenn L, Lefer, David J

“…BackgroundSustained increases in mitochondrial oxidative stress results in mitochondrial DNA (mtDNA) damage further worsening oxidative damage and cellular…”
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Abstract 85: A Novel Mitochondrial Targeted Fusion Protein Containing Endonuclease III Protects the Heart Against Myocardial Infarction and Pressure Overload Heart Failure by Bradley, Jessica M, Otsuka, Hiroyuki, Organ, Chelsea L, Bhushan, Shashi, Polhemus, David J, Wilson, Glenn L, Lefer, David J

“…Abstract only Background: Oxidative stress is a primary cause of mitochondrial DNA (mtDNA) damage and plays a role in myocardial cell death. mtDNA repair…”
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Lysyl oxidase inhibition in the volume overloaded heart prevents adverse collagen remodeling, apoptosis, and cardiac dysfunction by El Hajj, Milad C, Voloshenyuk, Tetyana G, Claudino, Mario A, Bradley, Jessica M, Gardner, Jason D

“…Abstract only Heart failure is the most prevalent and costly disease in the U.S. Our goal was to determine if the over‐activation of lysyl oxidase (LOX), a…”
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