Search Results - "Bradley, Heath L."

Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells by Metts, Jonathan, Bradley, Heath L., Wang, Zhengqi, Shah, Neil P., Kapur, Reuben, Arbiser, Jack L., Bunting, Kevin D.

“…Aberrant cytokine signaling initiated from mutant receptor tyrosine kinases (RTKs) provides critical growth and survival signals in high risk acute myeloid…”
Get full text

Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia by Wang, Zhengqi, Mi, Tian, Bradley, Heath L., Metts, Jonathan, Sabnis, Himalee, Zhu, Wandi, Arbiser, Jack, Bunting, Kevin D.

“…Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are…”
Get full text

Metagenomic Sequencing To Detect Respiratory Viruses in Persons under Investigation for COVID-19 by Babiker, Ahmed, Bradley, Heath L, Stittleburg, Victoria D, Ingersoll, Jessica M, Key, Autum, Kraft, Colleen S, Waggoner, Jesse J, Piantadosi, Anne

“…Broad testing for respiratory viruses among persons under investigation (PUIs) for SARS-CoV-2 has been performed inconsistently, limiting our understanding of…”
Get full text

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells by Bradley, Heath L., Hawley, Teresa S., Bunting, Kevin D.

“…Secreted growth factors are integral components of the bone marrow (BM) niche and can regulate survival, proliferation, and differentiation of committed…”
Get full text

Single-Amplicon Multiplex Real-Time Reverse Transcription-PCR with Tiled Probes To Detect SARS-CoV-2 spike Mutations Associated with Variants of Concern by Babiker, Ahmed, Immergluck, Katherine, Stampfer, Samuel D, Rao, Anuradha, Bassit, Leda, Su, Max, Nguyen, Vi, Stittleburg, Victoria, Ingersoll, Jessica M, Bradley, Heath L, Mavigner, Maud, Schoof, Nils, Kraft, Colleen S, Chahroudi, Ann, Schinazi, Raymond F, Martin, Greg S, Piantadosi, Anne, Lam, Wilbur A, Waggoner, Jesse J

“…To provide an accessible and inexpensive method to surveil for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations, we developed a multiplex…”
Get full text

Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine by Sabnis, Himalee S, Bradley, Heath L, Tripathi, Shweta, Yu, Wen-Mei, Tse, William, Qu, Cheng-Kui, Bunting, Kevin D

“…Graphical abstract…”
Get full text

Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression by Bunting, Kevin D., Yu, Wen‐Mei, Bradley, Heath L., Haviernikova, Eleonora, Kelly‐Welch, Ann E., Keegan, Achsah D., Qu, Cheng‐Kui

“…Signal transducer and activator of transcription‐6 (STAT6) plays important roles in cytokine signaling via interleukin‐4 and ‐13 receptors (IL‐4R and IL‐13R)…”
Get full text

Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia by Sabnis, Himalee, Bradley, Heath L, Bunting, Silvia T, Cooper, Todd M, Bunting, Kevin D

“…Overall cure rates in acute myeloid leukemia (AML) continue to range between 60-65% with disease relapse being a major cause of mortality. The PI3K-Akt-mTOR…”
Get full text

Unrecognized introductions of SARS-CoV-2 into the US state of Georgia shaped the early epidemic by Babiker, Ahmed, Martin, Michael A, Marvil, Charles, Bellman, Stephanie, Petit III, Robert A, Bradley, Heath L, Stittleburg, Victoria D, Ingersoll, Jessica, Kraft, Colleen S, Li, Yan, Zhang, Jing, Paden, Clinton R, Read, Timothy D, Waggoner, Jesse J, Koelle, Katia, Piantadosi, Anne

“…Abstract In early 2020, as diagnostic and surveillance responses for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ramped up, attention focused…”
Get full text

Hematopoietic reconstitution with androgenetic and gynogenetic stem cells by Eckardt, Sigrid, Leu, N Adrian, Bradley, Heath L, Kato, Hiromi, Bunting, Kevin D, McLaughlin, K John

“…Parthenogenetic embryonic stem (ES) cells with two oocyte-derived genomes (uniparental) have been proposed as a source of autologous tissue for…”
Get full text

Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5 by Bunting, Kevin D., Bradley, Heath L., Hawley, Teresa S., Moriggl, Richard, Sorrentino, Brian P., Ihle, James N.

“…Signal transducers and activators of transcription (STATs) are intracellular mediators of cytokine receptor signals. Because many early-acting growth factors…”
Get full text

Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness by Bradley, Heath L., Couldrey, Christine, Bunting, Kevin D.

“…Signal transducer and activator of transcription-5 (STAT5) plays an important role in repopulating activity of hematopoietic stem cells (HSCs). However, the…”
Get full text

A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis by Couldrey, Christine, Bradley, Heath L., Bunting, Kevin D.

“…Homologous disruption of expression of signal transducer and activator of transcription 5a (STAT5a) and STAT5b (STAT5ab–/–) in mice results in hematopoietic…”
Get full text

Nanoproteomic assays on hematopoietic stem cells by Bradley, Heath L, Sabnis, Himalee, Pritchett, Deborah, Bunting, Kevin D

“…Dysregulation of cytokine signaling pathways is associated with benign and malignant hematologic disorders. Improvements in therapy rely on understanding the…”
Get more information

Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation by HAVIERNIK, Peter, LAHODA, Carisa, BRADLEY, Heath L, HAWLEY, Teresa S, RAMEZANI, Ali, HAWLEY, Robert G, STETLER-STEVENSON, Maryalice, STETLER-STEVENSON, William G, BUNTING, Kevin D

“…The balance between matrix metalloproteinase (MMP) and tissue inhibitor of matrix metalloproteinase (TIMP) is important for extracellular matrix interactions…”
Get full text

64. Metagenomic Sequencing to Identify Alternative Infections and Co-infections in Persons Under Investigation for covid-19 by Babiker, Ahmed, Bradley, Heath L, Stittleburg, Victoria D, Key, Autum, Kraft, Colleen, Waggoner, Jesse, Piantadosi, Anne

“…Abstract Background Broad testing for respiratory viruses among persons under investigation (PUI) for SARS-CoV-2 is performed inconsistently, limiting our…”
Get full text

Imipramine Blue Sensitively and Selectively Targets FLT3 and c-Kit Mutant Acute Myeloid Leukemia by Metts, Jonathan L., Bradley, Heath L., Shah, Neil P., Kapur, Reuben, Arbiser, Jack L., Bunting, Kevin D.

“…Acute myeloid leukemia (AML) is the most common acute leukemia in adults and the 2nd most common in children. Despite advances in our understanding of AML…”
Get full text

Synergistic Cytotoxicity in Acute Myeloid Leukemia By Combined Treatment with Metformin and 6-Benzylthioinosine by Sabnis, Himalee S., Tripathi, Shweta, Bradley, Heath L, Yu, Wen-Mei, Tse, William, Qu, Cheng-Kui, Bunting, Kevin D.

“…Background: Cytogenetic and molecular aberrations have improved risk stratification of acute myeloid leukemia (AML) patients, however survival continues to be…”
Get full text