Search Results - "Bradley, Eamonn"

Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal by Fedigan, Stephen, Bradley, Eamonn, Webb, Timothy, Large, Roddy J., Hollywood, Mark A., Thornbury, Keith D., McHale, Noel G., Sergeant, Gerard P.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit Ca 2+ -activated Cl − currents ( I ClCa ) that are important for the development of…”
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Muscarinic Receptor Induced Contractions of the Detrusor are Mediated by Activation of TRPC4 Channels by Griffin, Caoimhin S, Bradley, Eamonn, Dudem, Srikanth, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…Purpose Muscarinic receptor mediated contractions of the detrusor rely on Ca2+ influx through voltage-gated Ca2+ channels but to our knowledge the mechanism…”
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Role of mitochondria in modulation of spontaneous Ca2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra by Sergeant, Gerard P., Bradley, Eamonn, Thornbury, Keith D., McHale, Noel G., Hollywood, Mark A.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit pacemaker activity that results from spontaneous Ca 2+ waves. The purpose of this…”
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Modulation of fast sodium current in airway smooth muscle cells by exchange protein directly activated by cAMP by Matthews, Ruth M, Bradley, Eamonn, Hollywood, Mark A, Lundy, Fionnuala T, McGarvey, Lorcan P, Sergeant, Gerard P, Thornbury, Keith D

“…Airway smooth muscle (ASM) cells from mouse bronchus express a fast sodium current mediated by Na 1.7. We present evidence that this current is regulated by…”
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Fast voltage‐dependent sodium (NaV) currents are functionally expressed in mouse corpus cavernosum smooth muscle cells by Lim, Xin Rui, Bradley, Eamonn, Griffin, Caoimhin S., Hollywood, Mark A., Sergeant, Gerard P., Thornbury, Keith D.

“…Background and Purpose Corpus cavernosum smooth muscle (CCSM) exhibits phasic contractions that are coordinated by ion channels. Mouse models are commonly used…”
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Effects of L‐type Ca2+ blockers and the novel BKCa channel opener, GoSlo‐SR5‐130, on tension responses in rabbit bronchial rings by Thornbury, Keith D, Bihun, Victoriia Volodymyrivna, Bradley, Eamonn, Hollywood, Mark A, Sergeant, Gerard P

“…Although airway smooth muscle cells express L‐type Ca2+ channels and large conductance Ca2+‐ activated K+ (BKCa) channels, the role of these voltage‐dependent…”
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Effects of L‐type Ca 2+ blockers and the novel BK Ca channel opener, GoSlo‐SR5‐130, on tension responses in rabbit bronchial rings by Thornbury, Keith D, Bihun, Victoriia Volodymyrivna, Bradley, Eamonn, Hollywood, Mark A, Sergeant, Gerard P

“…Although airway smooth muscle cells express L‐type Ca 2+ channels and large conductance Ca 2+ ‐ activated K + (BK Ca ) channels, the role of these…”
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Involvement of cyclic nucleotide-gated channels in spontaneous activity generated in isolated interstitial cells of Cajal from the rabbit urethra by Sancho, Maria, Bradley, Eamonn, Garcia-Pascual, Angeles, Triguero, Domingo, Thornbury, Keith D., Hollywood, Mark A., Sergeant, Gerard P.

“…Cyclic nucleotide-gated (CNG) channels are non-selective cation channels that mediate influx of extracellular Na+ and Ca2+ in various cell types…”
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β3‐adrenoceptor agonists inhibit carbachol‐evoked Ca2+ oscillations in murine detrusor myocytes by Griffin, Caoimhin S., Bradley, Eamonn, Hollywood, Mark A., McHale, Noel G., Thornbury, Keith D., Sergeant, Gerard P.

“…Objective To test if carbachol (CCh)‐evoked Ca2+ oscillations in freshly isolated murine detrusor myocytes are affected by β3‐adrenoceptor (β‐AR) modulators…”
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β3-adrenoceptor agonists inhibit carbachol-evoked Ca 2+ oscillations in murine detrusor myocytes by Griffin, Caoimhin S, Bradley, Eamonn, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…To test if carbachol (CCh)-evoked Ca oscillations in freshly isolated murine detrusor myocytes are affected by β3-adrenoceptor (β-AR) modulators. Isometric…”
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Pharmacological characterization of TMEM16A currents by Bradley, Eamonn, Fedigan, Stephen, Webb, Timothy, Hollywood, Mark A, Thornbury, Keith D, McHale, Noel G, Sergeant, Gerard P

“…Recent studies have shown that transmembrane protein 16 A (TMEM16A) is a subunit of calcium-activated chloride channels (CACCs). Pharmacological agents have…”
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Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists by Kyle, Barry D, Bradley, Eamonn, Large, Roddy, Sergeant, Gerard P, McHale, Noel G, Thornbury, Keith D, Hollywood, Mark A

“…We used the perforated patch-clamp technique at 37°C to investigate the mechanisms underlying the activation of a transient large-conductance K(+) (tBK)…”
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P2X receptor currents in smooth muscle cells contribute to nerve mediated contractions of rabbit urethral smooth muscle by Bradley, Eamonn, Kadima, Sonia, Kyle, Barry, Hollywood, Mark A, Thornbury, Keith D, McHale, Noel G, Sergeant, Gerard P

“…Adenosine triphosphate is capable of relaxing and contracting urethral smooth muscle. The mechanisms responsible for the relaxing effects of adenosine…”
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Novel excitatory effects of adenosine triphosphate on contractile and pacemaker activity in rabbit urethral smooth muscle by Bradley, Eamonn, Kadima, Sonia, Drumm, Bernard, Hollywood, Mark A, Thornbury, Keith D, McHale, Noel G, Sergeant, Gerard P

“…Adenosine triphosphate is thought to be an important neurotransmitter in urethral smooth muscle but its physiological role is still unclear. We characterized…”
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Role of mitochondria in modulation of spontaneous Ca super(2+) waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra by Sergeant, Gerard P, Bradley, Eamonn, Thornbury, Keith D, McHale, Noel G, Hollywood, Mark A

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit pacemaker activity that results from spontaneous Ca super(2+) waves. The purpose of…”
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Role of mitochondria in modulation of spontaneous Ca 2+ waves in freshly dispersed interstitial cells of Cajal from the rabbit urethra by Sergeant, Gerard P., Bradley, Eamonn, Thornbury, Keith D., McHale, Noel G., Hollywood, Mark A.

“…Interstitial cells of Cajal (ICC) isolated from the rabbit urethra exhibit pacemaker activity that results from spontaneous Ca 2+ waves. The purpose of this…”
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Effects of varying impulse number on cotransmitter contributions to sympathetic vasoconstriction in rat tail artery by Bradley, Eamonn, Law, Andrea, Bell, David, Johnson, Christopher D

“…We examined the contributions of the cotransmitters norepinephrine (NE), ATP, and neuropeptide Y (NPY) to sympathetically evoked vasoconstriction in the rat…”
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Pacemaker activity in urethral interstitial cells is not dependent on capacitative calcium entry by Bradley, Eamonn, Hollywood, Mark A, McHale, Noel G, Thornbury, Keith D, Sergeant, Gerard P

“…The aim of the present study was to investigate the properties and role of capacitative Ca(2+) entry (CCE) in interstitial cells (IC) isolated from the rabbit…”
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