Search Results - "Bradfield, A."

Medial Orbitofrontal Cortex Mediates Outcome Retrieval in Partially Observable Task Situations by Bradfield, Laura A., Dezfouli, Amir, van Holstein, Mieke, Chieng, Billy, Balleine, Bernard W.

“…Choice between actions often requires the ability to retrieve action consequences in circumstances where they are only partially observable. This capacity has…”
Get full text

The Thalamostriatal Pathway and Cholinergic Control of Goal-Directed Action: Interlacing New with Existing Learning in the Striatum by Bradfield, Laura A., Bertran-Gonzalez, Jesus, Chieng, Billy, Balleine, Bernard W.

“…The capacity for goal-directed action depends on encoding specific action-outcome associations, a learning process mediated by the posterior dorsomedial…”
Get full text

Prefrontal Corticostriatal Disconnection Blocks the Acquisition of Goal-Directed Action by Hart, Genevra, Bradfield, Laura A, Balleine, Bernard W

“…The acquisition of goal-directed action requires encoding of the association between an action and its specific consequences or outcome. At a neural level,…”
Get full text

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis by Pan, Xiaoyue, Bradfield, Christopher A., Hussain, M. Mahmood

“…Circadian rhythms controlled by clock genes affect plasma lipids. Here we show that global ablation of Bmal1 in Apoe −/− and Ldlr −/− mice and its…”
Get full text

The Bilateral Prefronto-striatal Pathway Is Necessary for Learning New Goal-Directed Actions by Hart, Genevra, Bradfield, Laura A., Fok, Sandra Y., Chieng, Billy, Balleine, Bernard W.

“…The acquisition of new goal-directed actions requires the encoding of action-outcome associations. At a neural level, this encoding has been hypothesized to…”
Get full text

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor by Nguyen, Linh P, Bradfield, Christopher A

“…The primary design of this perspective is to describe the major ligand classes of the aryl hydrocarbon receptor (AHR). A grander objective is to provide models…”
Get full text

Mammalian Per-Arnt-Sim proteins in environmental adaptation by McIntosh, Brian E, Hogenesch, John B, Bradfield, Christopher A

“…The Per-Arnt-Sim (PAS) domain is conserved across the kingdoms of life and found in an ever-growing list of proteins. This domain can bind to and sense…”
Get full text

The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model by Avilla, Mele N, Malecki, Kristen M. C, Hahn, Mark E, Wilson, Rachel H, Bradfield, Christopher A

“…The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many important questions about its role in normal physiology and…”
Get full text

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch by Lee, Jacob S, Cella, Marina, McDonald, Keely G, Garlanda, Cecilia, Kennedy, Gregory D, Nukaya, Manabu, Mantovani, Alberto, Kopan, Raphael, Bradfield, Christopher A, Newberry, Rodney D, Colonna, Marco

“…The generation of certain gut innate lymphoid cell (ILC) populations requires the aryl hydrocarbon receptor (AHR). Colonna and colleagues show that the…”
Get full text

The aryl hydrocarbon receptor: a perspective on potential roles in the immune system by Stevens, Emily A., Mezrich, Joshua D., Bradfield, Christopher A.

“…Summary The aryl hydrocarbon receptor (AHR) is a protein best known for its role in mediating toxicity. Over 30 years of research has uncovered additional…”
Get full text

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes by Bass, Joseph, Marcheva, Biliana, Ramsey, Kathryn Moynihan, Buhr, Ethan D, Kobayashi, Yumiko, Su, Hong, Ko, Caroline H, Ivanova, Ganka, Omura, Chiaki, Mo, Shelley, Vitaterna, Martha H, Lopez, James P, Philipson, Louis H, Bradfield, Christopher A, Crosby, Seth D, JeBailey, Lellean, Wang, Xiaozhong, Takahashi, Joseph S

“…The molecular clock maintains energy constancy by producing circadian oscillations of rate-limiting enzymes involved in tissue metabolism across the day and…”
Get full text

Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex by Seok, Seung-Hyeon, Lee, Woojong, Jiang, Li, Molugu, Kaivalya, Zheng, Aiping, Li, Yitong, Park, Sanghyun, Bradfield, Christopher A., Xing, Yongna

“…The aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and mediates broad responses to numerous environmental…”
Get full text

Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron by Cedernaes, Jonathan, Huang, Wenyu, Ramsey, Kathryn Moynihan, Waldeck, Nathan, Cheng, Lei, Marcheva, Biliana, Omura, Chiaki, Kobayashi, Yumiko, Peek, Clara Bien, Levine, Daniel C., Dhir, Ravindra, Awatramani, Raj, Bradfield, Christopher A., Wang, Xiaozhong A., Takahashi, Joseph S., Mokadem, Mohamad, Ahima, Rexford S., Bass, Joseph

“…The alignment of fasting and feeding with the sleep/wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain…”
Get full text

The circadian clock is disrupted in pancreatic cancer by Schwartz, Patrick B, Nukaya, Manabu, Berres, Mark E, Rubinstein, Clifford D, Wu, Gang, Hogenesch, John B, Bradfield, Christopher A, Ronnekleiv-Kelly, Sean M

“…Disruption of the circadian clock is linked to cancer development and progression. Establishing this connection has proven beneficial for understanding cancer…”
Get full text

Interaction of insular cortex and ventral striatum mediates the effect of incentive memory on choice between goal-directed actions by Parkes, Shauna L, Bradfield, Laura A, Balleine, Bernard W

“…The anterior insular cortex (IC) and the nucleus accumbens (NAc) core have been separately implicated in the selection and performance of actions based on the…”
Get full text

Rodent genetic models of Ah receptor signaling by Wilson, Rachel H., Bradfield, Christopher A.

“…The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the PER-ARNT-SIM superfamily of environmental sensors. This…”
Get full text

Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro by O'Driscoll, Chelsea A, Gallo, Madeline E, Hoffmann, Erica J, Fechner, John H, Schauer, James J, Bradfield, Christopher A, Mezrich, Joshua D

“…Atmospheric particulate matter (PM) is a complex component of air pollution that is a composed of inorganic and organic constituents. The chemically-extracted…”
Get full text

Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate Action Selection by Bradfield, Laura A, Becchi, Serena, Kendig, Michael D

“…Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this…”
Get more information

Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation by Teffera, Menna, Veith, Alex C., Ronnekleiv-Kelly, Sean, Bradfield, Christopher A., Nikodemova, Maria, Tussing-Humphreys, Lisa, Malecki, Kristen

“…The human gut microbiome, the host, and the environment are inextricably linked across the life course with significant health impacts. Consisting of trillions…”
Get full text

Punishment insensitivity emerges from impaired contingency detection, not aversion insensitivity or reward dominance by Jean-Richard-Dit-Bressel, Philip, Ma, Cassandra, Bradfield, Laura A, Killcross, Simon, McNally, Gavan P

“…Our behaviour is shaped by its consequences - we seek rewards and avoid harm. It has been reported that individuals vary markedly in their avoidance of…”
Get full text