Search Results - "Bradesi, S"

Role of spinal cord glia in the central processing of peripheral pain perception by Bradesi, S.

“…Background  The discovery that glial activation plays a critical role in the modulation of neuronal functions and affects the spinal processing of nociceptive…”
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Functional GI disorders: from animal models to drug development by Mayer, E A, Bradesi, S, Chang, L, Spiegel, B M R, Bueller, J A, Naliboff, B D

“…Despite considerable efforts by academic researchers and by the pharmaceutical industry, the development of novel pharmacological treatments for irritable…”
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Guanylate cyclase C‐mediated antinociceptive effects of linaclotide in rodent models of visceral pain by Eutamene, H., Bradesi, S., Larauche, M., Theodorou, V., Beaufrand, C., Ohning, G., Fioramonti, J., Cohen, M., Bryant, A. P., Kurtz, C., Currie, M. G., Mayer, E. A., Bueno, L.

“…Background  Linaclotide is a novel, orally administered investigational drug currently in clinical development for the treatment of constipation‐predominant…”
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Review article: modulation of the brain–gut axis as a therapeutic approach in gastrointestinal disease by MAYER, E. A., TILLISCH, K., BRADESI, S.

“…Summary Background The importance of bi‐directional brain‐gut interactions in gastrointestinal illness is increasingly being recognized, most prominently in…”
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Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase by Ait-Belgnaoui, Afifa, Bradesi, Sylvie, Fioramonti, Jean, Theodorou, Vassilia, Bueno, Lionel

“…Hypersensitivity to rectal or colonic distension characterizes most patients with IBS and increased gut permeability has been described in post-dysenteric IBS…”
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PAR4: A new role in the modulation of visceral nociception by Bradesi, S.

“…Protease‐activated receptors (PARs) are a family of G‐protein‐coupled receptors with a widespread distribution that are involved in various physiological…”
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Gut microbiota and neurogastroenterology and motility: the good the bad and the ugly by Farrugia, G., Simren, M., Mawe, G., Bradesi, S., Bredenoord, A. J.

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Neurogastroenterology and Motility going online only in January 2014 by Farrugia, G., Mawe, G., Simren, M., Bradesi, S., Bredenoord, A.

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Acute and chronic stress differently affect visceral sensitivity to rectal distension in female rats by BRADESI, S., EUTAMENE, H., GARCIA‐VILLAR, R., FIORAMONTI, J., BUÉNO, L.

“…Stressful life events are frequently associated with outward signs of irritable bowel syndrome (IBS). Increasing evidence suggests that acute and chronic…”
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Stress-induced visceral hypersensitivity in female rats is estrogen-dependent and involves tachykinin NK1 receptors by Bradesi, Sylvie, Eutamene, Helene, Garcia-Villar, Rafael, Fioramonti, Jean, Bueno, Lionel

“…Hormonal cycling may be related to a higher incidence of pain syndrome in female. As tachykinins are pivotal in stress-induced colonic dysfunction, we…”
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Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids by Bradesi, S, Eutamene, H, Fioramonti, J, Bueno, L

“…Background and aims: Psychological factors have been implicated in the aetiology of irritable bowel syndrome characterised by intestinal altered motility and…”
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Inflammatory bowel disease and irritable bowel syndrome: separate or unified? by Bradesi, Sylvie, McRoberts, James A, Anton, Peter A, Mayer, Emeran A

“…Both irritable bowel syndrome and inflammatory bowel diseases share symptoms of altered bowel habits associated with abdominal pain or discomfort. Irritable…”
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The pathophysiology of irritable bowel syndrome by Schwetz, I, Bradesi, S, Mayer, E A

“…Recent studies have provided evidence to suggest a possible role for mucosal immune activation in the pathophysiology of irritable bowel syndrome (IBS). On the…”
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Effect of ovarian hormones on intestinal mast cell reactivity to Substance P by Bradesi, S., Eutamene, H., Theodorou, V., Fioramonti, J., Bueno, L.

“…Evidence exists to support the concept that ovarian hormones influence mast cell functioning and related events. Here, we evaluated the constitutive gender…”
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Role of spinal cord glia in the central processing of peripheral pain perception: Spinal glia and pain processing by Bradesi, S.

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Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia by Bradesi, Sylvie, Schwetz, Ines, Ennes, Helena S, Lamy, Christophe M R, Ohning, Gordon, Fanselow, Michael, Pothoulakis, Charalabos, McRoberts, James A, Mayer, Emeran A

“…Chronic stress plays an important role in the development and exacerbation of symptoms in functional gastrointestinal disorders. To better understand the…”
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Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress by Bradesi, Sylvie, Svensson, Camilla I, Steinauer, Joanne, Pothoulakis, Charalabos, Yaksh, Tony L, Mayer, Emeran A

“…Background & Aims Chronic psychological stress is associated with visceral hyperalgesia and increased expression of spinal NK1 receptors (NK1Rs). We aimed to…”
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Visceral analgesics: drugs with a great potential in functional disorders? by Bradesi, Sylvie, Herman, Jeremy, Mayer, Emeran A

“…Irritable bowel syndrome remains an incompletely understood, common syndrome with significant unmet medical needs. In IBS patients, abdominal pain is a primary…”
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Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats by Schwetz, Ines, McRoberts, James A, Coutinho, Santosh V, Bradesi, Sylvie, Gale, Greg, Fanselow, Michael, Million, Mulugeta, Ohning, Gordon, Taché, Yvette, Plotsky, Paul M, Mayer, Emeran A

“…In rodents, maternal pup interactions play an important role in programming the stress responsiveness of the adult organism. The aims of this study were 1) to…”
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Novel therapeutic approaches in IBS by Bradesi, Sylvie, Mayer, Emeran A

“…Irritable bowel syndrome (IBS) remains an incompletely understood, common syndrome with significant unmet medical needs. Significant progress has been made in…”
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