Search Results - "Brader, M L"

Spectroscopic signatures of the T to R conformational transition in the insulin hexamer by Roy, M, Brader, M L, Lee, R W, Kaarsholm, N C, Hansen, J F, Dunn, M F

“…The cobalt(II)-substituted human insulin hexamer has been shown to undergo the phenol-induced T6 to R6 structural transition in solution. The accompanying…”
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Effects of non-covalent self-association on the subcutaneous absorption of a therapeutic peptide by CLODFELTER, D. K, PEKAR, A. H, REBHUN, D. M, DESTRAMPE, K. A, HAVEL, H. A, MYERS, S. R, BRADER, M. L

“…To utilize an acylated peptide as a model system to investigate the relationships among solution peptide conformation, non-covalent self-association,…”
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Allosteric transition of the insulin hexamer is modulated by homotropic and heterotropic interactions by Choi, Wonjae E., Brader, Mark L., Aguilar, Valentin, Kaarsholm, Niels C., Dunn, Michael F.

“…The allosteric behavior of the Co(II)-substituted insulin hexamer has been investigated using electronic spectroscopy to study the binding of different…”
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Characterization of the r-state insulin hexamer and its derivatives. The hexamer is stabilized by heterotropic ligand binding interactions by Brader, Mark L, Kaarsholm, Niels C, Lee, Robert W. K, Dunn, Michael F

“…1H NMR and UV-visible electronic absorption studies have been performed to investigate the effects of anions and cyclic organic molecules on the…”
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Hybrid insulin cocrystals for controlled release delivery by Brader, Mark L, Myers, Sharon R, Sukumar, Muppalla, Pekar, Allen H, McClellan, David S, Chance, Ronald E, Flora, David B, Cox, Amy L, Irwin, Lynnie

“…The ability to tailor the release profile of a drug by manipulating its formulation matrix offers important therapeutic advantages. We show here that human…”
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The R-state proinsulin and insulin hexamers mimic the carbonic anhydrase active site by BRADER, M. LO, KAARSHILM, N. C, DUNN, M. F

“…The cobalt(II)-substituted proinsulin and insulin hexamers have been studied in solution via electronic absorption spectroscopy. Hexameric proinsulin is shown…”
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Atomic Force Microscopy of Crystalline Insulins: The Influence of Sequence Variation on Crystallization and Interfacial Structure by Yip, Christopher M., Brader, Mark L., DeFelippis, Michael R., Ward, Michael D.

“…The self-association of proteins is influenced by amino acid sequence, molecular conformation, and the presence of molecular additives. In the presence of…”
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Structural and Morphological Characterization of Ultralente Insulin Crystals by Atomic Force Microscopy: Evidence of Hydrophobically Driven Assembly by Yip, Christopher M., DeFelippis, Michael R., Frank, Bruce H., Brader, Mark L., Ward, Michael D.

“…Although x-ray crystal structures exist for many forms of insulin, the hormone involved in glucose metabolism and used in the treatment of diabetes, x-ray…”
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Structural Studies of a Crystalline Insulin Analog Complex with Protamine by Atomic Force Microscopy by Yip, Christopher M., Brader, Mark L., Frank, Bruce H., DeFelippis, Michael R., Ward, Michael D.

“…Crystallographic studies of insulin–protamine complexes, such as neutral protamine Hagedorn (NPH) insulin, have been hampered by high crystal solvent content,…”
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Insulin hexamers: new conformations and applications by Brader, M L, Dunn, M F

“…Recent studies on the structural and chemical properties of insulin have shown that the insulin hexamer is an allosteric protein capable of adopting three…”
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Zinc Coordination, Asymmetry, and Allostery of the Human Insulin Hexamer by Brader, Mark L

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Physicochemical basis for the rapid time‐action of LysB28ProB29‐insulin: Dissociation of a protein‐ligand complex by Bakaysa, Diane L., Radziuk, Jerry, Havel, Henry A., Brader, Mark L., Li, Shun, Dodd, Steven W., Beals, John M., Pekar, Allen H., Brems, David N.

“…The rate‐limiting step for the absorption of insulin solutions after subcutaneous injection is considered to be the dissociation of self‐associated hexamers to…”
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Ligand effects on the blue copper site. Spectroscopic studies of an insulin-stabilized copper(II) chromophore incorporating an exogenous thiolate ligand by Brader, Mark L, Borchardt, Dan, Dunn, Michael F

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Insulin stabilizes copper(II)-thiolate ligation that models blue copper proteins by Brader, Mark L, Dunn, Michael F

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Ligand perturbation effects on a pseudotetrahedral Co(II)(His)3-ligand site. A magnetic circular dichroism study of the Co(II)-substituted insulin hexamer by Brader, M L, Kaarsholm, N C, Harnung, S E, Dunn, M F

“…Magnetic circular dichroism (MCD) spectra of a series of adducts formed by the Co(II)-substituted R-state insulin hexamer are reported. The His-B10 residues in…”
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Biophysical signatures of noncovalent aggregates formed by a glucagonlike peptide-1 analog: a prototypical example of biopharmaceutical aggregation by Doyle, Brandon L, Pollo, Mark J, Pekar, Allen H, Roy, Michael L, Thomas, Beth Ann, Brader, Mark L

“…LY307161 is a 31 amino acid analog of glucagonlike peptide-1(7-37)OH susceptible to physical instability associated with pharmaceutical processing. Orthogonal…”
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The T to R transition in the Copper(II)-substituted insulin hexamer. Anion complexes of the R-states species exhibiting type 1 and type 2 spectral characteristics by BRADER, M. L, BORCHARDT, D, DUNN, M. F

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The T to R transition in the copper(II)-substituted insulin hexamer. Anion complexes of the R-state species exhibiting type 1 and type 2 spectral characteristics by Brader, Mark L, Borchardt, Dan, Dunn, Michael F

“…The R-state conformation of the Cu(II)-substituted insulin hexamer has been identified, and a number of its derivatives have been studied via 1H NMR, ESR, and…”
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