Search Results - "Braden, Timothy M"

Small-Volume Continuous Manufacturing of Merestinib. Part 1. Process Development and Demonstration by Cole, Kevin P, Reizman, Brandon J, Hess, Molly, Groh, Jennifer M, Laurila, Michael E, Cope, Richard F, Campbell, Bradley M, Forst, Mindy B, Burt, Justin L, Maloney, Todd D, Johnson, Martin D, Mitchell, David, Polster, Christopher S, Mitra, Aurpon W, Boukerche, Moussa, Conder, Edward W, Braden, Timothy M, Miller, Richard D, Heller, Michael R, Phillips, Joseph L, Howell, John R

“…Development of a small volume continuous process that used a combination of batch and flow unit operations to manufacture the small molecule oncolytic…”
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Development of Pilot-Scale Continuous Production of an LY2886721 Starting Material by Packed-Bed Hydrogenolysis by Zaborenko, Nikolay, Linder, Ryan J, Braden, Timothy M, Campbell, Bradley M, Hansen, Marvin M, Johnson, Martin D

“…The design, development, and implementation of a pilot-scale continuous hydrogenolysis in a catalytic packed bed to generate a starting material is described…”
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Improved Synthesis of 1-(Azidomethyl)-3,5-bis-(trifluoromethyl)benzene: Development of Batch and Microflow Azide Processes by Kopach, Michael E, Murray, Michael M, Braden, Timothy M, Kobierski, Michael E, Williams, Otis L

“…A batch process was developed to produce 1-(azidomethyl)-3,5-bis-(trifluoromethyl)benzene, 1, in 94% yield by an efficient nucleophilic substitution reaction…”
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The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations by McWilliams, J. Christopher, Allian, Ayman D, Opalka, Suzanne M, May, Scott A, Journet, Michel, Braden, Timothy M

“…This manuscript provides the results of an in-depth survey assessment of the capabilities, experience, and perspectives on continuous processing in the…”
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Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing by Frederick, Michael O, Boyse, Raymond A, Braden, Timothy M, Calvin, Joel R, Campbell, Bradley M, Changi, Shujauddin M, Coffin, Stephanie R, Condon, Carmel, Gowran, Olivia, McClary Groh, Jennifer, Groskreutz, Stephen R, Harms, Zachary D, Humenik, Ashley A, Kallman, Neil J, Klitzing, Nicholas D, Kopach, Michael E, Kretsinger, Juliana K, Lambertus, Gordon R, Lampert, Jeffrey T, Maguire, Laura M, Moynihan, Humphrey A, Mullane, Nessa S, Murphy, John D, O’Mahony, Marie E, Richey, Rachel N, Seibert, Kevin D, Spencer, Richard D, Strege, Mark A, Tandogan, Nil, Torres Torres, Frank L, Tsukanov, Sergey V, Xia, Han

“…The large-scale manufacture of complex synthetic peptides is challenging due to many factors such as manufacturing risk (including failed product…”
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Small-Volume Continuous Manufacturing of Merestinib. Part 2. Technology Transfer and cGMP Manufacturing by Reizman, Brandon J, Cole, Kevin P, Hess, Molly, Burt, Justin L, Maloney, Todd D, Johnson, Martin D, Laurila, Michael E, Cope, Richard F, Luciani, Carla V, Buser, Jonas Y, Campbell, Bradley M, Forst, Mindy B, Mitchell, David, Braden, Timothy M, Lippelt, Christopher K, Boukerche, Moussa, Starkey, Derek R, Miller, Richard D, Chen, Jing, Sun, Baoquan, Kwok, Martin, Zhang, Xin, Tadayon, Sam, Huang, Ping

“…Technology transfer of a small volume continuous (SVC) process and Current Good Manufacturing Practices (cGMP) manufacturing of merestinib are described. A…”
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Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material by Kopach, Michael E, Cole, Kevin P, Pollock, Patrick M, Johnson, Martin D, Braden, Timothy M, Webster, Luke P, McClary Groh, Jennifer, McFarland, Adam D, Schafer, John P, Adler, Jonathan J, Rosemeyer, Morgan

“…Efficient continuous Grignard and lithiation processes were developed to produce one of the key regulatory starting materials for the production of edivoxetine…”
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Development of a Commercial Flow Barbier Process for a Pharmaceutical Intermediate by Braden, Timothy M, Johnson, Martin D, Kopach, Michael E, McClary Groh, Jennifer, Spencer, Richard D, Lewis, Jeffrey, Heller, Michael R, Schafer, John P, Adler, Jonathan J

“…A flow Barbier process was developed to produce a key intermediate in the edivoxetine·HCl registered sequence. The control strategy was developed based on a…”
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Development of Universal, Automated Sample Acquisition, Preparation, and Delivery Devices and Methods for Pharmaceutical Applications by Lambertus, Gordon R, Webster, Luke P, Braden, Timothy M, Campbell, Bradley M, McClary Groh, Jennifer, Maloney, Todd D, Milenbaugh, Paul, Spencer, Richard D, Sun, Wei-ming, Johnson, Martin D

“…Continued emphasis in the pharmaceutical industry toward development of hybrid and continuous processes has led to a resurgence in process analytical…”
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Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors by May, Scott A, Johnson, Martin D, Braden, Timothy M, Calvin, Joel R, Haeberle, Brian D, Jines, Amy R, Miller, Richard D, Plocharczyk, Edward F, Rener, Gregory A, Richey, Rachel N, Schmid, Christopher R, Vaid, Radhe K, Yu, Hannah

“…The development of reactions in a continuous fashion in plug flow tube reactors (PFR) offers unique advantages to the drug development and scale-up process and…”
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Development of an Enantioselective Hydrogenation Based Synthesis of a Glucokinase Activator by Magnus, Nicholas A, Braden, Timothy M, Buser, Jonas Y, DeBaillie, Amy C, Heath, Perry C, Ley, Christopher P, Remacle, Jacob R, Varie, David L, Wilson, Thomas M

“…This article describes the development and optimization of chemical reactions and subsequent multikilogram preparation of the glucokinase activator (R)-1 to…”
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The Role of New Technologies in Defining a Manufacturing Process for PPARα Agonist LY518674 by Argentine, Mark D, Braden, Timothy M, Czarnik, Jeffrey, Conder, Edward W, Dunlap, Steven E, Fennell, Jared W, LaPack, Mark A, Rothhaar, Roger R, Scherer, R. Brian, Schmid, Christopher R, Vicenzi, Jeffrey T, Wei, Jeffrey G, Werner, John A, Roginski, Robert T

“…The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology…”
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A Convergent Kilogram-Scale Synthesis of the PPARα Agonist LY518674:  Discovery of a Novel Acid-Mediated Triazolone Synthesis by Braden, Timothy M, Coffey, D. Scott, Doecke, Christopher W, LeTourneau, Michael E, Martinelli, Michael J, Meyer, Christopher L, Miller, Richard D, Pawlak, Joseph M, Pedersen, Steven W, Schmid, Christopher R, Shaw, Bruce W, Staszak, Michael A, Vicenzi, Jeffrey T

“…The first kilogram-scale synthesis of the PPARα agonist LY518674 (1) is described. The de novo convergent synthetic approach involved coupling of two rapidly…”
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Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction by Calvin, Joel R., Boyse, Raymond, Braden, Timothy M., Brewer, Alison C., Changi, Shujauddin, Harrold, Donal, Johnson, Martin, Kerr, Mark S., Lambertus, Gordon R., Luciani, Carla V., May, Scott A., Moloney, Harold, Murphy, John D., Roberts, Jeffrey C., Schafer, John P., Spencer, Richard D., Webster, Luke P.

“…A synthetic route to API was designed containing a Negishi cross-coupling reaction, where the zincate reagent was generated by transmetalation of a Grignard…”
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Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors by May, Scott A., Johnson, Martin D., Braden, Timothy M., Calvin, Joel R., Haeberle, Brian D., Jines, Amy R., Miller, Richard D., Plocharczyk, Edward F., Rener, Gregory A., Richey, Rachel N., Schmid, Christopher R., Vaid, Radhe K., Yu, Hannah

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