Search Results - "Bradbury, C. Matthew"

Epigenetic silencing of novel tumor suppressors in malignant melanoma by MUTHUSAMY, Viswanathan, DURAISAMY, Sekhar, BRADBURY, C. Matthew, HOBBS, Cara, CURLEY, David P, NELSON, Betsy, BOSENBERG, Marcus

“…Malignant melanoma is a common and frequently lethal disease. Current therapeutic interventions have little effect on survival, emphasizing the need for a…”
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Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation by KARIMPOUR, Shervin, JUNYANG LOU, SPITZ, Douglas R, HIROTA, Kiichi, KALVAKOLANU, Dhananjaya V, YODOI, Junji, GIUS, David, LIN, Lilie L, RENE, Luis M, LAGUNAS, Lucio, XINRONG MA, KARRA, Sreenivasu, BRADBURY, C. Matthew, MARKOVINA, Stephanie, GOSWAMI, Prabhat C

“…A recently identified class of signaling factors uses critical cysteine motif(s) that act as redox-sensitive 'sulfhydryl switches' to reversibly modulate…”
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DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation by Sun, Lunching, Huang, Lei, Nguyen, Phuongmai, Bisht, Kheem S, Bar-Sela, Gil, Ho, Allen S, Bradbury, C Matthew, Yu, Wenqiang, Cui, Hengmi, Lee, Sunmin, Trepel, Jane B, Feinberg, Andrew P, Gius, David

“…In a previous genomic analysis, using somatic methyltransferase (DNMT) knockout cells, we showed that hypomethylation decreased the expression of as many genes…”
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DNMT1 as a Molecular Target in a Multimodality-Resistant Phenotype in Tumor Cells by Mishra, Mark V, Bisht, Kheem S, Sun, Lunching, Muldoon-Jacobs, Kristi, Awwad, Rania, Kaushal, Aradhana, Nguyen, Phuongmai, Huang, Lei, Pennington, J Daniel, Markovina, Stephanie, Bradbury, C Matthew, Gius, David

“…We have previously shown that hydrogen peroxide–resistant permanent (OC-14) cells are resistant to the cytotoxicity of several exogenous oxidative and…”
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Radiation Therapy for Local Cutaneous Melanoma by Dabestani, Parinaz J., Dawson, Amanda J., Neumeister, Michael W., Bradbury, C. Matthew

“…While primary treatment for melanoma consists of surgical resection and chemotherapeutics, radiation can be used as either definitive or adjuvant therapy in…”
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Distinct Effects of Ionizing Radiation on In vivo Murine Kidney and Brain Normal Tissue Gene Expression by Zhao, Weiling, Chuang, Eric Y, Mishra, Mark, Awwad, Rania, Bisht, Kheem, Sun, Lunching, Nguyen, Phuongmai, Pennington, J Daniel, Wang, Tony Jau Cheng, Bradbury, C Matthew, Huang, Lei, Chen, Zhijun, Bar-Sela, Gil, Robbins, Michael E C, Gius, David

“…Purpose: There is a growing awareness that radiation-induced normal tissue injury in late-responding organs, such as the brain, kidney, and lung, involves…”
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Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates by GIUS, David, FUNK, Margo C, COHN, David E, POWELL, Matthew A, HOROWITZ, Neil S, WHITCOMB, Bradford P, RADER, Janet S, CHUANG, Eric Y, SHENG FENG, HUETTNER, Phyllis C, NGUYEN, Loan, BRADBURY, C. Matthew, MISHRA, Mark, SHUPING GAO, BUTTIN, Barbara M

“…This study is the first comprehensive, integrated approach to examine grade-specific changes in gene expression along the entire neoplastic spectrum of…”
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Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity by BISHT, Kheem S, BRADBURY, C. Matthew, MITCHELL, James B, NECKERS, Leonard M, GIUS, David, MATTSON, David, KAUSHAL, Aradhana, SOWERS, Anastasia, MARKOVINA, Stephanie, ORTIZ, Karen L, SIECK, Leah K, ISAACS, Jennifer S, BRECHBIEL, Martin W

“…Ansamycin antibiotics inhibit function of the heat shock protein (HSP) 90, causing selective degradation of several intracellular proteins regulating such…”
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2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism by XIAO LIN, FANJIE ZHANG, BRADBURY, C. Matthew, KAUSHAL, Aradhana, LING LI, SPITZ, Douglas R, AFT, Rebecca L, GIUS, David

“…Exposure to ionizing radiation is believed to cause cell injury via the production of free radicals that are thought to induce oxidative damage. It has been…”
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Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach by Gius, David, Cui, Hengmi, Bradbury, C.Matthew, Cook, John, Smart, DeeDee K., Zhao, Shuping, Young, Lynn, Brandenburg, Sheri A., Hu, Yali, Bisht, Kheem S., Ho, Allen S., Mattson, David, Sun, Lunching, Munson, Peter J., Chuang, Eric Y., Mitchell, James B., Feinberg, Andrew P.

“…We tested the hypothesis that the effects on gene expression of altered DNA methylation by 5-aza-2′-deoxycytidine (5-aza-CdR) and genetic ( DNMT knockout)…”
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Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress by SMART, Deedee K, ORTIZ, Karen L, MATTSON, David, BRADBURY, C. Matthew, BISHT, Kheem S, SIECK, Leah K, BRECHBIEL, Martin W, GIUS, David

“…Redox-sensitive signaling factors regulate multiple cellular processes, including proliferation, cell cycle, and prosurvival signaling cascades, suggesting…”
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Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell lines by Zoberi, Imran, Bradbury, C.Matthew, Curry, Heather A., Bisht, Kheem S., Goswami, Prabhat C., Roti Roti, Joseph L., Gius, David

“…Resveratrol is a polyphenol isolated from the skins of grapes that has been shown to significantly alter the cellular physiology of tumor cells, as well as…”
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Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells by Lagunas, Lucio, Bradbury, C.Matthew, Laszlo, Andrei, Hunt, Clayton R, Gius, David

“…It has been established that non-steroidal anti-inflammatory drugs (NSAIDs), such as sodium salicylate, sulindac, ibuprofen, and indomethacin, induce…”
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The epigenome as a molecular marker and target by Gius, David, Bradbury, C. Matthew, Sun, Lunching, Awwad, Rania T., Huang, Lei, Smart, Dee Dee K., Bisht, Kheem S., Ho, Allen S., Nguyen, Phuongmai

“…Tumor cell proliferation, de‐differentiation, and progression depend on a complex combination of altered cell cycle regulation, excessive growth factor pathway…”
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Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation by WEI, S. Jack, BOTERO, Ana, HIROTA, Kiichi, BRADBURY, C. Matthew, MARKOVINA, Stephanie, LASZLO, Andrei, SPITZ, Douglas R, GOSWAMI, Prabhat C, YODOI, Junji, GIUS, David

“…Thioredoxin (TRX) is a cytoplasmic, redox-sensitive signaling factor believed to participate in the regulation of nuclear transcription factors mediating…”
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The epigenome as a molecular marker and target : Implications for cancer by GIUS, David, BRADBURY, C. Matthew, LUNCHING SUN, AWWAD, Rania T, LEI HUANG, SMART, Dee Dee K, BISHT, Kheem S, HO, Alien S, NGUYEN, Phuongmai

“…Tumor cell proliferation, de‐differentiation, and progression depend on a complex combination of altered cell cycle regulation, excessive growth factor pathway…”
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Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hydrogen peroxide, and cisplatin are inhibited by indomethacin in oxidative stress-resistant cells by BRADBURY, C. Matthew, LOCKE, Jacob E, WEI, S. Jack, RENE, Luis M, KARIMPOUR, Shervin, HUNT, Clayton, SPITZ, Douglas R, GIUS, David

“…It has been established that tumor cells develop resistance to a variety of therapeutic agents after multiple exposures to these agents/drugs. Many of these…”
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Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-KB activation in HeLa cells occur via a mechanism involving p38 MAP kinase by BRADBURY, C. Matthew, MARKOVINA, Stephanie, WEI, S. Jack, RENE, Luis M, ZOBERI, Imran, HORIKOSHI, Nobuo, GIUS, David

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