Search Results - "Brad D. Manion"

A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors by Evers, Alex S, Chen, Zi-Wei, Manion, Brad D, Han, Mingcheng, Jiang, Xin, Darbandi-Tonkabon, Ramin, Kable, Tristan, Bracamontes, John, Zorumski, Charles F, Mennerick, Steven, Steinbach, Joe Henry, Covey, Douglas F

“…In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [35S]t-butylbicyclophosphorothionate in a biphasic manner,…”
Get more information

Activation and modulation of recombinant glycine and GABA A receptors by 4-halogenated analogues of propofol by Germann, Allison L, Shin, Daniel J, Manion, Brad D, Edge, Christopher J, Smith, Edward H, Franks, Nicholas P, Evers, Alex S, Akk, Gustav

“…Glycine receptors are important players in pain perception and movement disorders and therefore important therapeutic targets. Glycine receptors can be…”
Get full text

Neurosteroid Analogues. 18. Structure–Activity Studies of ent-Steroid Potentiators of γ‑Aminobutyric Acid Type A Receptors and Comparison of Their Activities with Those of Alphaxalone and Allopregnanolone by Qian, Mingxing, Krishnan, Kathiresan, Kudova, Eva, Li, Ping, Manion, Brad D, Taylor, Amanda, Elias, George, Akk, Gustav, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…A model of the alignment of neurosteroids and ent-neurosteroids at the same binding site on γ-aminobutyric acid type A (GABAA) receptors was evaluated for its…”
Get full text

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors by Chen, Zi-Wei, Wang, Cunde, Krishnan, Kathiresan, Manion, Brad D., Hastings, Randy, Bracamontes, John, Taylor, Amanda, Eaton, Megan M., Zorumski, Charles F., Steinbach, Joseph H., Akk, Gustav, Mennerick, Steven, Covey, Douglas F., Evers, Alex S.

“…Rationale While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A (GABA A ) receptors, the binding sites that…”
Get full text

Neurosteroid Analogues. 17. Inverted Binding Orientations of Androsterone Enantiomers at the Steroid Potentiation Site on γ-Aminobutyric Acid Type A Receptors by Krishnan, Kathiresan, Manion, Brad D, Taylor, Amanda, Bracamontes, John, Steinbach, Joseph H, Reichert, David E, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…The enantiomer pair androsterone and ent-androsterone are positive allosteric modulators of γ-aminobutyric acid (GABA) type A receptors. Each enantiomer was…”
Get full text

Neurosteroid Analogues. 16. A New Explanation for the Lack of Anesthetic Effects of Δ16-Alphaxalone and Identification of a Δ17(20) Analogue with Potent Anesthetic Activity by Stastna, Eva, Krishnan, Kathiresan, Manion, Brad D, Taylor, Amanda, Rath, Nigam P, Chen, Zi-Wei, Evers, Alex. S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…This study addresses the hypothesis that the lack of anesthetic activity for (3α,5α)-3-hydroxypregn-16-ene-11,20-dione (Δ16-alphaxalone) is explained by the…”
Get full text

Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity by Stastna, Eva, Krishnan, Kathiresan, Manion, Brad D, Taylor, Amanda, Rath, Nigam P, Chen, Zi-Wei, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…This study addresses the hypothesis that the lack of anesthetic activity for (3α,5α)-3-hydroxypregn-16-ene-11,20-dione (Δ(16)-alphaxalone) is explained by the…”
Get full text

Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens by KATONA, Bryson W, KRISHNAN, Kathiresan, ZU YUN CAI, MANION, Brad D, BENZ, Ann, TAYLOR, Amanda, EVERS, Alex S, ZORUMSKI, Charles F, MENNERICK, Steven, COVEY, Douglas F

“…Allopregnanolone (1) and pregnanolone (2), steroids containing a 17beta-acetyl group, are potent enhancers of GABA (gamma-aminobutyric acid) action at GABAA…”
Get full text

Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain by Darbandi-Tonkabon, Ramin, Hastings, William R, Zeng, Chun-Min, Akk, Gustav, Manion, Brad D, Bracamontes, John R, Steinbach, Joseph H, Mennerick, Steven J, Covey, Douglas F, Evers, Alex S

“…Neuroactive steroids modulate the function of gamma-aminobutyric acid, type A (GABA(A)) receptors in the central nervous system by an unknown mechanism. In…”
Get full text

Neurosteroid Analogues. 14. Alternative Ring System Scaffolds: GABA Modulatory and Anesthetic Actions of Cyclopenta[b]phenanthrenes and Cyclopenta[b]anthracenes by Scaglione, Jamie B, Jastrzebska, Izabella, Krishnan, Kathiresan, Li, Ping, Akk, Gustav, Manion, Brad D, Benz, Ann, Taylor, Amanda, Rath, Nigam P, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…Although the structural features of binding sites for neuroactive steroids on γ-aminobutryic acid type A (GABAA) receptors are still largely unknown,…”
Get full text

Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues by Bandyopadhyaya, Achintya K., Manion, Brad D., Benz, Ann, Taylor, Amanda, Rath, Nigam P., Evers, Alex S., Zorumski, Charles F., Mennerick, Steven, Covey, Douglas F.

“…Alphaxalone, a neuroactive steroid containing a 17β-acetyl group, has potent anesthetic activity in humans. This pharmacological activity is attributed to this…”
Get full text

Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light by Mennerick, Steven, Manion, Brad D, Akk, Gustav, Zorumski, Charles F, Wang, Cunde, Covey, Douglas F, Shu, Hong-Jin, Steinbach, Joe Henry, Eisenman, Lawrence N, Evers, Alex S, Kress, Geraldine J

“…Most photoactivatable compounds suffer from the limitations of the ultraviolet wavelengths that are required for activation. We synthesized a neuroactive…”
Get full text

Neurosteroid Analogues. 11. Alternative Ring System Scaffolds:  γ-Aminobutyric Acid Receptor Modulation and Anesthetic Actions of Benz[f]indenes by Scaglione, Jamie B, Manion, Brad D, Benz, Ann, Taylor, Amanda, DeKoster, Gregory T, Rath, Nigam P, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…Benz[f]indenes are tricyclic compounds with a linear 6-6-5 fused carbocyclic ring system. When properly substituted, benz[f]indenes can satisfy the…”
Get full text

Neurosteroid Analogues. 10. The Effect of Methyl Group Substitution at the C-6 and C-7 Positions on the GABA Modulatory and Anesthetic Actions of (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one by Zeng, Chun-min, Manion, Brad D, Benz, Ann, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…The planar 5α-reduced steroid (3α,5α)-3-hydroxypregnan-20-one and the nonplanar 5β-reduced steroid (3α,5β)-3-hydroxypregnan-20-one act at GABAA receptors to…”
Get full text

Neurosteroid Analogues. 9. Conformationally Constrained Pregnanes:  Structure−Activity Studies of 13,24-Cyclo-18,21-dinorcholane Analogues of the GABA Modulatory and Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one by Jiang, Xin, Manion, Brad D, Benz, Ann, Rath, Nigam P, Evers, Alex S, Zorumski, Charles F, Mennerick, Steven, Covey, Douglas F

“…The hydrogen-bond-acceptor properties of the carbonyl moiety in the 17β-acetyl group on the D-ring of the anesthetic steroids (3α,5α)- and…”
Get full text

Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia by Darbandi-Tonkabon, Ramin, Manion, Brad D, Hastings, William R, Craigen, William J, Akk, Gustav, Bracamontes, John R, He, Yejun, Sheiko, Tatiana V, Steinbach, Joseph H, Mennerick, Steven J, Covey, Douglas F, Evers, Alex S

“…Neuroactive steroids modulate the function of gamma-aminobutyric acid type A (GABA(A)) receptors in brain; this is the presumed basis of their action as…”
Get more information

Photoaffinity Labeling with a Neuroactive Steroid Analogue by Ramin Darbandi-Tonkabon, William R. Hastings, Chun-Min Zeng, Gustav Akk, Brad D. Manion, John R. Bracamontes, Joseph H. Steinbach, Steven J. Mennerick, Douglas F. Covey, Alex S. Evers

“…Neuroactive steroids modulate the function of γ-aminobutyric acid, type A (GABA A ) receptors in the central nervous system by an unknown mechanism. In this…”
Get full text

Activation and modulation of recombinant glycine and GABA sub(A) receptors by 4-halogenated analogues of propofol by Germann, Allison L, Shin, Daniel J, Manion, Brad D, Edge, Christopher J, Smith, Edward H, Franks, Nicholas P, Evers, Alex S, Akk, Gustav

“…Background and Purpose Glycine receptors are important players in pain perception and movement disorders and therefore important therapeutic targets. Glycine…”
Get full text

Activation and modulation of recombinant glycine and GABAA receptors by 4‐halogenated analogues of propofol by Germann, Allison L, Shin, Daniel J, Manion, Brad D, Edge, Christopher J, Smith, Edward H, Franks, Nicholas P, Evers, Alex S, Akk, Gustav

“…Background and Purpose Glycine receptors are important players in pain perception and movement disorders and therefore important therapeutic targets. Glycine…”
Get full text

11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for [GABA.sub.A] receptors by Chen, Zi-Wei, Wang, Cunde, Krishnan, Kathiresan, Manion, Brad D, Hastings, Randy, Bracamontes, John, Taylor, Amanda, Eaton, Megan M, Zorumski, Charles F, Steinbach, Joseph H, Akk, Gustav, Mennerick, Steven, Covey, Douglas F, Evers, Alex S

“…Rationale While neurosteroids are well-described positive allosteric modulators of gamma-aminobutyric acid type A ([GABA.sub.A]) receptors, the binding sites…”
Get full text