Search Results - "Bracken, A P"

Transcriptional regulation of cellular senescence by Lanigan, F, Geraghty, J G, Bracken, A P

“…Cellular senescence is an irreversible arrest of proliferation. It is activated when a cell encounters stress such as DNA damage, telomere shortening or…”
Get full text

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer by Bracken, Adrian P., Pasini, Diego, Capra, Maria, Prosperini, Elena, Colli, Elena, Helin, Kristian

“…Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly expressed in metastatic prostate cancer and in lymphomas. EZH2 is a…”
Get full text

Anticancer innovative therapy: Highlights from the ninth annual meeting by Volpari, T., De Santis, F., Bracken, A.P., Pupa, S.M., Buschbeck, M., Wegner, A., Di Cosimo, S., Lisanti, MP, Dotti, G., Massaia, M., Pruneri, G., Anichini, A., Fortunato, O., De Braud, F., Del Vecchio, M., Di Nicola, M.

“…The Ninth Annual Conference of “Anticancer Innovative Therapy”, organized by Fondazione IRCCS Istituto Nazionale dei Tumori di Milano (Fondazione IRCCS INT)…”
Get full text

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis by Müller, H, Bracken, A P, Vernell, R, Moroni, M C, Christians, F, Grassilli, E, Prosperini, E, Vigo, E, Oliner, J D, Helin, K

“…The retinoblastoma protein (pRB) and its two relatives, p107 and p130, regulate development and cell proliferation in part by inhibiting the activity of…”
Get full text

Regulation of stem cell differentiation by histone methyltransferases and demethylases by Pasini, D, Bracken, A P, Agger, K, Christensen, J, Hansen, K, Cloos, P A C, Helin, K

“…The generation of different cell types from stem cells containing identical genetic information and their organization into tissues and organs during…”
Get full text

Reassembly and protection of small nuclear ribonucleoprotein particles by heat shock proteins in yeast cells by BRACKEN, ADRIAN P., BOND, URSULA

“…The process of mRNA splicing is sensitive to in vivo thermal inactivation, but can be protected by pretreatment of cells under conditions that induce…”
Get full text

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions by Bracken, Adrian P, Dietrich, Nikolaj, Pasini, Diego, Hansen, Klaus H, Helin, Kristian

“…The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly…”
Get full text

E2F target genes: unraveling the biology by Bracken, Adrian P., Ciro, Marco, Cocito, Andrea, Helin, Kristian

“…The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes…”
Get full text

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity by Pasini, Diego, Bracken, Adrian P, Jensen, Michael R, Denchi, Eros Lazzerini, Helin, Kristian

“…SUZ12 is a recently identified Polycomb group (PcG) protein, which together with EZH2 and EED forms different Polycomb repressive complexes (PRC2/3). These…”
Get full text

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias by Krivtsov, Andrei V., Feng, Zhaohui, Lemieux, Madeleine E., Faber, Joerg, Vempati, Sridhar, Sinha, Amit U., Xia, Xiaobo, Jesneck, Jonathan, Bracken, Adrian P., Silverman, Lewis B., Kutok, Jeffery L., Kung, Andrew L., Armstrong, Scott A.

“…We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias…”
Get full text

The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages by Huang, Zhiqiang, Liang, Ning, Goñi, Saioa, Damdimopoulos, Anastasios, Wang, Cheng, Ballaire, Raphaelle, Jager, Jennifer, Niskanen, Henri, Han, Hongya, Jakobsson, Tomas, Bracken, Adrian P., Aouadi, Myriam, Venteclef, Nicolas, Kaikkonen, Minna U., Fan, Rongrong, Treuter, Eckardt

“…While the role of transcription factors and coactivators in controlling enhancer activity and chromatin structure linked to gene expression is well…”
Get full text

CHD5 Is Required for Neurogenesis and Has a Dual Role in Facilitating Gene Expression and Polycomb Gene Repression by Egan, Chris M., Nyman, Ulrika, Skotte, Julie, Streubel, Gundula, Turner, Siobhán, O’Connell, David J., Rraklli, Vilma, Dolan, Michael J., Chadderton, Naomi, Hansen, Klaus, Farrar, Gwyneth Jane, Helin, Kristian, Holmberg, Johan, Bracken, Adrian P.

“…The chromatin remodeler CHD5 is expressed in neural tissue and is frequently deleted in aggressive neuroblastoma. Very little is known about the function of…”
Get full text

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription by Christensen, Jesper, Cloos, Paul, Toftegaard, Ulla, Klinkenberg, David, Bracken, Adrian P., Trinh, Emmanuelle, Heeran, Mel, Di Stefano, Luisa, Helin, Kristian

“…The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of…”
Get full text

Polycomb group proteins in cell cycle progression and cancer by Pasini, Diego, Bracken, Adrian P, Helin, Kristian

“…Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive…”
Get full text

Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation by Brien, Gerard L., Bracken, Adrian P.

“…Mammalian development is a highly complex and tightly regulated process. Transcription factors and chromatin remodelers, acting downstream of cell signalling…”
Get full text

NPAT Expression Is Regulated by E2F and Is Essential for Cell Cycle Progression by Gao, Guang, Bracken, Adrian P., Burkard, Karina, Pasini, Diego, Classon, Marie, Attwooll, Claire, Sagara, Masashi, Imai, Takashi, Helin, Kristian, Zhao, Jiyong

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Profiling cancer by Ciro, Marco, Bracken, Adrian P, Helin, Kristian

“…In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and…”
Get full text