Search Results - "Brackeen, Marcus"

Assessment of the Antinociceptive, Respiratory-Depressant, and Reinforcing Effects of the Low pK a Fluorinated Fentanyl Analogs, FF3 and NFEPP by Edwards, Shelley R, Blough, Bruce E, Cowart, Kristian, Howell, Grace H, Araujo, Aaron A, Haskell, Jacob P, Huskinson, Sally L, Rowlett, James K, Brackeen, Marcus F, Freeman, Kevin B

“…Recent studies report that fentanyl analogs with relatively low pK values produce antinociception in rodents without other mu opioid-typical side effects due…”
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Assessment of the antinociceptive, respiratory-depressant, and reinforcing effects of the low pKa fluorinated fentanyl analogs, FF3 and NFEPP by Edwards, Shelley R., Blough, Bruce E., Cowart, Kristian, Howell, Grace H., Araujo, Aaron A., Haskell, Jacob P., Huskinson, Sally L., Rowlett, James K., Brackeen, Marcus F., Freeman, Kevin B.

“…Recent studies report that fentanyl analogs with relatively low pKa values produce antinociception in rodents without other mu opioid-typical side effects due…”
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Identification of a Potent Human Trace Amine-Associated Receptor 1 Antagonist by Decker, Ann M, Brackeen, Marcus F, Mohammadkhani, Aida, Kormos, Chad M, Hesk, David, Borgland, Stephanie L, Blough, Bruce E

“…Human trace amine-associated receptor subtype 1 (hTAAR1) is a G protein-coupled receptor that has therapeutic potential for multiple diseases, including…”
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Evaluation of cannabimimetic effects of selected minor cannabinoids and Terpenoids in mice by Wiley, Jenny L., Marusich, Julie A., Blough, Bruce E., Namjoshi, Ojas, Brackeen, Marcus, Akinfiresoye, Luli R., Walker, Teneille D., Prioleau, Cassandra, Barrus, Daniel G., Gamage, Thomas F.

“…The cannabis plant contains several cannabinoids, and many terpenoids that give cannabis its distinctive flavoring and aroma. Δ9-Tetrahydrocannabinol (Δ9-THC)…”
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Design and Synthesis of Conformationally Constrained Analogs of 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as Potent Inhibitors of cAMP-Specific Phosphodiesterase by Brackeen, Marcus F, Stafford, Jeffrey A, Cowan, David J, Brown, Peter J, Domanico, Paul L, Feldman, Paul L, Rose, Dudley, Strickland, Alan B, Veal, James M, Verghese, Margrith

“…The synthesis and biological evaluation of cAMP-specific phosphodiesterase (PDE IV) inhibitors is described. The PDE IV inhibitor…”
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Phosphodiesterase Type IV Inhibition. Structure-Activity Relationships of 1,3-Disubstituted Pyrrolidines by Feldman, Paul L, Brackeen, Marcus F, Cowan, David J, Marron, Brian E, Schoenen, Frank J, Stafford, Jeffrey A, Suh, Edward M, Domanico, Paul L, Rose, Dudley

“…The synthesis of 1,3-disubstituted pyrrolidines 2 and their activities as type IV phosphodiesterase (PDE) inhibitors are described. Various groups were…”
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Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of methyl (R,R)-(.+-.)-3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase by Stafford, Jeffrey A, Veal, James M, Feldman, Paul L, Valvano, Nicole L, Baer, Philip G, Brackeen, Marcus F, Brawley, E. Sloan, Connolly, Kevin M, Domanico, Paul L

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Conformationally Constrained Analogues of N-(Piperidinyl)-5-(4-Chlorophenyl)-1-(2,4- Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxamide (SR141716): Design, Synthesis, Computational Analysis, And Biological Evaluations by Zhang, Yanan, Burgess, Jason P, Brackeen, Marcus, Gilliam, Anne, Mascarella, S. Wayne, Page, Kevin, Seltzman, Herbert H, Thomas, Brian F

“…Structure−activity relationships (SARs) of 1 (SR141716) have been extensively documented, however, the conformational properties of this class have received…”
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N-(2-Benzoylphenyl)-l-tyrosine PPARγ Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents by Henke, Brad R, Blanchard, Steven G, Brackeen, Marcus F, Brown, Kathleen K, Cobb, Jeff E, Collins, Jon L, Harrington, W. Wallace, Hashim, Mir A, Hull-Ryde, Emily A, Kaldor, Istvan, Kliewer, Steven A, Lake, Debra H, Leesnitzer, Lisa M, Lehmann, Jürgen M, Lenhard, James M, Orband-Miller, Lisa A, Miller, John F, Mook, Robert A, Noble, Stewart A, Oliver, William, Parks, Derek J, Plunket, Kelli D, Szewczyk, Jerzy R, Willson, Timothy M

“…We have identified a novel series of antidiabetic N-(2-benzoylphenyl)-l-tyrosine derivatives which are potent, selective PPARγ agonists. Through the use of in…”
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Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgesics by Feldman, Paul L, James, Michael K, Brackeen, Marcus F, Bilotta, Joanne M, Schuster, Suzanne V, Lahey, Avis P, Lutz, Michael W, Johnson, M. Ross, Leighton, H. Jeff

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Conformationally Constrained Analogues of N -(Piperidinyl)-5-(4-Chlorophenyl)-1-(2,4- Dichlorophenyl)-4-Methyl-1 H -Pyrazole-3-Carboxamide (SR141716): Design, Synthesis, Computational Analysis, And Biological Evaluations by Zhang, Yanan, Burgess, Jason P., Brackeen, Marcus, Gilliam, Anne, Mascarella, S. Wayne, Page, Kevin, Seltzman, Herbert H., Thomas, Brian F.

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Conformational characteristics of the interaction of SR141716A with the CB1 cannabinoid receptor as determined through the use of conformationally constrained analogs by Thomas, Brian F, Zhang, Yanan, Brackeen, Marcus, Page, Kevin M, Mascarella, S Wayne, Seltzman, Herbert H

“…Interest in cannabinoid pharmacology increased dramatically upon the identification of the first cannabinoid receptor (CB1) in 1998 and continues to expand as…”
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Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics by FELDMAN, P. L, JAMES, M. K, BRACKEEN, M. F, BILOTTA, J. M, SCHUSTER, S. V, LAHEY, A. P, LUTZ, M. W, JOHNSON, M. R, LEIGHTON, H. J

“…In an effort to discover a potent ultrashort-acting mu opioid analgetic that is capable of metabolizing to an inactive species independent of hepatic function,…”
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A novel route to the 4-anilido-4-(methoxycarbonyl)piperidine class of analgetics by Feldman, Paul L., Brackeen, Marcus F.

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Evaluation of the significance of elevated levels of systemic and localized tumor necrosis factor in different animal models of inflammation by Sekut, L, Menius, Jr, J A, Brackeen, M F, Connolly, K M

“…Elevated tumor necrosis factor (TNF) levels have been reported in various models of acute and chronic inflammation and used by many investigators to determine…”
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