Search Results - "Braciale, Thomas"

The host immune response in respiratory virus infection: balancing virus clearance and immunopathology by Newton, Amy H., Cardani, Amber, Braciale, Thomas J.

“…The respiratory tract is constantly exposed to the external environment, and therefore, must be equipped to respond to and eliminate pathogens. Viral clearance…”
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Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection by Gorski, Stacey Ann, Hahn, Young S, Braciale, Thomas J

“…Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine) immune response, however, the production of type…”
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Viral infection of the lung: Host response and sequelae by Yoo, Jae-Kwang, PhD, Kim, Taeg S., PhD, Hufford, Matthew M., PhD, Braciale, Thomas J., MD, PhD

“…Because of its essential role in gas exchange and oxygen delivery, the lung has evolved a variety of strategies to control inflammation and maintain…”
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Alveolar Macrophages Prevent Lethal Influenza Pneumonia By Inhibiting Infection Of Type-1 Alveolar Epithelial Cells by Cardani, Amber, Boulton, Adam, Kim, Taeg S, Braciale, Thomas J

“…The Influenza A virus (IAV) is a major human pathogen that produces significant morbidity and mortality. To explore the contribution of alveolar macrophages…”
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Regulating the adaptive immune response to respiratory virus infection by Braciale, Thomas J., Sun, Jie, Kim, Taeg S.

“…Key Points The respiratory tract is a major portal of entry for viruses into the body. Infection of the respiratory tract can, if severe, induce…”
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Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10 by Madan, Rajat, Braciale, Thomas J, Karp, Christopher L, Sun, Jie

“…Interleukin-10 is known to dampen immune responses and contribute to the persistence of chronic viruses and parasites. Thomas Braciale and his colleagues show…”
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Respiratory dendritic cell subsets differ in their capacity to support the induction of virus-specific cytotoxic CD8+ T cell responses by Kim, Taeg S, Braciale, Thomas J

“…Dendritic cells located at the body surfaces, e.g. skin, respiratory and gastrointestinal tract, play an essential role in the induction of adaptive immune…”
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Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8+ T Cell Differentiation by a CD24-Dependent Mechanism by Kim, Taeg S., Gorski, Stacey A., Hahn, Steven, Murphy, Kenneth M., Braciale, Thomas J.

“…The contribution of different DC subsets to effector and memory CD8+ T cell generation during infection and the mechanism by which DCs controls these fate…”
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Expression of IL-5 receptor alpha by murine and human lung neutrophils by Gorski, Stacey A, Lawrence, Monica G, Hinkelman, Amy, Spano, MarthaJoy M, Steinke, John W, Borish, Larry, Teague, W Gerald, Braciale, Thomas J

“…The role of eosinophilia in atopic diseases, including asthma, is well established, as is the well-known role of IL-5 as a major eosinophilopoeitin and…”
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Immune surveillance by rhinovirus-specific circulating CD4+ and CD8+ T lymphocytes by Steinke, John W, Liu, Lixia, Turner, Ronald B, Braciale, Thomas J, Borish, Larry

“…It is difficult to experimentally infect volunteers with RV strains to which the subject demonstrates serological immunity. However, in RV challenges, viral…”
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The cell cycle time of CD8+ T cells responding in vivo is controlled by the type of antigenic stimulus by Yoon, Heesik, Kim, Taeg S, Braciale, Thomas J

“…A hallmark of cells comprising the mammalian adaptive immune system is the requirement for these rare naïve T (and B) lymphocytes directed to a specific…”
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Immunity to viruses by Braciale, Thomas J., Hahn, Young S.

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Influenza-infected neutrophils within the infected lungs act as antigen presenting cells for anti-viral CD8(+) T cells by Hufford, Matthew M, Richardson, Graham, Zhou, Haixia, Manicassamy, Balaji, García-Sastre, Adolfo, Enelow, Richard I, Braciale, Thomas J

“…Influenza A virus (IAV) is a leading cause of respiratory tract disease worldwide. Anti-viral CD8(+) T lymphocytes responding to IAV infection are believed to…”
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Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner by Moser, Emily K, Hufford, Matthew M, Braciale, Thomas J

“…Influenza A virus (IAV) infection in the respiratory tract triggers robust innate and adaptive immune responses, resulting in both virus clearance and lung…”
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CD4 + T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs by Braciale, Thomas J, Sun, Jie, Dodd, Haley, Moser, Emily K, Sharma, Rahul

“…CTLs can produce the regulatory cytokine IL-10 to prevent excess inflammation during clearance of viruses. Braciale and colleagues now unravel the molecular…”
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Role of T cell immunity in recovery from influenza virus infection by Sun, Jie, Braciale, Thomas J

“…•Local interaction between APCs and T cells controls influenza T cell responses.•Effector T cells use multiple mechanisms to restrict influenza…”
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Type I IFN signaling facilitates the development of IL‐10‐producing effector CD8+ T cells during murine influenza virus infection by Jiang, Li, Yao, Shuyu, Huang, Su, Wright, Jeffrey, Braciale, Thomas J., Sun, Jie

“…Recent evidence has suggested that IL‐10‐producing effector CD8+ T cells play an important role in regulating excessive inflammation during acute viral…”
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Bronchoalveolar lavage cytokine patterns in children with severe neutrophilic and paucigranulocytic asthma by Steinke, John W., Lawrence, Monica G., Teague, W. Gerald, Braciale, Thomas J., Patrie, James T., Borish, Larry

“…Asthma is a complex heterogeneous disease occurring in adults and children that is characterized by distinct inflammatory patterns. While numerous studies have…”
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Antiviral CD8+ T cell effector activities in situ are regulated by target cell type by Hufford, Matthew M, Kim, Taeg S, Sun, Jie, Braciale, Thomas J

“…Cytotoxic T lymphocytes (CTLs) play a prominent role in the resolution of viral infections through their capacity both to mediate contact-dependent lysis of…”
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Leptin Receptor Deficiency Impairs Lymph Node Development and Adaptive Immune Response by Cardani-Boulton, Amber, Sung, Sun-Sang J, Petri, Jr, William A, Hahn, Young S, Braciale, Thomas J

“…Activation and clonal expansion of the Ag-specific adaptive immune response in the draining lymph node is essential to clearing influenza A virus infections…”
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