Search Results - "Braciale, TJ"

Activation, Differentiation, and Migration of Naive Virus-Specific CD8+ T Cells during Pulmonary Influenza Virus Infection by Lawrence, Christopher W, Braciale, Thomas J

“…The low precursor frequency of individual virus-specific CD8(+) T cells in a naive host makes the early events of CD8(+) T cell activation, proliferation, and…”
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Respiratory syncytial virus infection suppresses lung CD8 + T-cell effector activity and peripheral CD8 + T-cell memory in the respiratory tract by Braciale, Thomas J, Chang, Jun

“…Respiratory syncytial virus (RSV) is a major cause of morbidity from respiratory infection in infants, young children and the elderly. No effective vaccine…”
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Lymph Node Dendritic Cells Control CD8 + T Cell Responses through Regulated FasL Expression by Legge, Kevin L., Braciale, Thomas J.

“…The lethal outcome of high-dose pulmonary virus infection is thought to reflect high-level, sustained virus replication and associated lung inflammation prior…”
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Accelerated Migration of Respiratory Dendritic Cells to the Regional Lymph Nodes Is Limited to the Early Phase of Pulmonary Infection by Legge, Kevin L, Braciale, Thomas J

“…Respiratory dendritic cells (RDC) are believed to play a central role in the induction of adaptive immune responses to pulmonary infection. Herein we examine…”
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Preferential migration of effector CD8+ T cells into the interstitium of the normal lung by Galkina, Elena, Thatte, Jayant, Dabak, Vrushali, Williams, Mark B, Ley, Klaus, Braciale, Thomas J

“…The respiratory tract is a primary site of infection and exposure to environmental antigens and an important site of memory T cell localization. We analyzed…”
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Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection by Yao, S, Jiang, L, Moser, E K, Jewett, L B, Wright, J, Du, J, Zhou, B, Davis, S D, Krupp, N L, Braciale, T J, Sun, J

“…Respiratory syncytial virus (RSV) infection is a leading cause of severe lower respiratory tract illness in young infants, the elderly and immunocompromised…”
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Frequency, Specificity, and Sites of Expansion of CD8+ T Cells during Primary Pulmonary Influenza Virus Infection by Lawrence, Christopher W, Ream, Rebecca M, Braciale, Thomas J

“…We have used intracellular cytokine staining and MHC class I tetramer binding in conjunction with granzyme B protease expression and in vivo BrdU uptake to…”
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Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection by Srikiatkhachorn, A, Braciale, T J

“…T lymphocytes play a pivotal role in the immune response during viral infections. In a murine model of experimental respiratory syncytial virus (RSV)…”
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Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation by Kittlesen, D J, Chianese-Bullock, K A, Yao, Z Q, Braciale, T J, Hahn, Y S

“…Hepatitis C virus (HCV) is an important human pathogen that is remarkably efficient at establishing persistent infection. The HCV core protein is the first…”
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Resistance to and recovery from lethal influenza virus infection in B lymphocyte-deficient mice by Graham, M B, Braciale, T J

“…In the adaptive immune response to most viruses, both the cellular and humoral arms of the immune system play complementary roles in eliminating virus and…”
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Visualization and Characterization of Respiratory Syncytial Virus F-Specific CD8+ T Cells During Experimental Virus Infection by Chang, Jun, Srikiatkhachorn, Anon, Braciale, Thomas J

“…CTL play a major role in the clearance of respiratory syncytial virus (RSV) during experimental pulmonary infection. The fusion (F) glycoprotein of RSV is a…”
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Immunopathology in RSV Infection Is Mediated by a Discrete Oligoclonal Subset of Antigen-Specific CD4 + T Cells by Varga, Steven M, Wang, Xiaoting, Welsh, Raymond M, Braciale, Thomas J

“…Vaccination with the respiratory syncytial virus (RSV) attachment (G) protein results in immune-mediated lung injury after natural RSV infection with…”
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LFA-1 is required for retention of effector CD8 T cells in mouse lungs by Thatte, Jayant, Dabak, Vrushali, Williams, Mark B., Braciale, Thomas J., Ley, Klaus

“…The adhesion molecules involved in the migration and retention of activated effector CD8 T cells in the lung microcirculation and their recruitment into lung…”
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Cutting Edge: Lipid Raft Integrity Affects the Efficiency of MHC Class I Tetramer Binding and Cell Surface TCR Arrangement on CD8+ T Cells by Drake, Donald R., III, Braciale, Thomas J

“…Physically distinct cholesterol/sphingolipid-rich plasma membrane microdomains, so-called lipid rafts, have been recognized to play an important regulatory…”
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Comparative Activities of Oseltamivir and A-322278 in Immunocompetent and Immunocompromised Murine Models of Influenza Virus Infection by Ison, Michael G., Mishin, Vasiliy P., Braciale, Thomas J., Hayden, Frederick G., Gubareva, Larisa V.

“…We developed an immunocompromised murine model of influenza virus infection and demonstrated comparable efficacy of oral oseltamivir and A-322278 (both given…”
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Influenza virus-specific CD4+ T helper type 2 T lymphocytes do not promote recovery from experimental virus infection by Graham, M B, Braciale, V L, Braciale, T J

“…T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity. Although viral-specific CD8+ and CD4+ T cells have been shown to…”
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Induction of Th-1 and Th-2 Responses by Respiratory Syncytial Virus Attachment Glycoprotein Is Epitope and Major Histocompatibility Complex Independent by Srikiatkhachorn, A, Chang, W, Braciale, T J

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Transient Loss of MHC Class I Tetramer Binding after CD8+ T Cell Activation Reflects Altered T Cell Effector Function by Drake, Donald R., III, Ream, Rebecca M, Lawrence, Christopher W, Braciale, Thomas J

“…Engagement of the Ag receptor on naive CD8+ T cells by specific peptide-MHC complex triggers their activation/expansion/differentiation into effector CTL. The…”
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Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection by Srikiatkhachorn, A, Braciale, T J

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Improved Effector Activity and Memory CD8 T Cell Development by IL-2 Expression during Experimental Respiratory Syncytial Virus Infection by Chang, Jun, Choi, So Young, Jin, Hyun Tak, Sung, Young Chul, Braciale, Thomas J

“…Respiratory syncytial virus (RSV) is a major cause of lower respiratory infection in young children and the elderly. Studies of mice suggest that RSV…”
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