Search Results - "Bracho, Olena"

Laminin-coated electrodes improve cochlear implant function and post-insertion neuronal survival by Bas, Esperanza, Anwar, Mir R., Goncalves, Stefania, Dinh, Christine T., Bracho, Olena R., Chiossone, Juan A., Van De Water, Thomas R.

“…The benefits of Cochlear implant (CI) technology depend among other factors on the proximity of the electrode array to the spiral ganglion neurons. Laminin, a…”
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Combination Therapy with c-Met and Src Inhibitors Induces Caspase-Dependent Apoptosis of Merlin-Deficient Schwann Cells and Suppresses Growth of Schwannoma Cells by Fuse, Marisa A, Plati, Stephani Klingeman, Burns, Sarah S, Dinh, Christine T, Bracho, Olena, Yan, Denise, Mittal, Rahul, Shen, Rulong, Soulakova, Julia N, Copik, Alicja J, Liu, Xue Zhong, Telischi, Fred F, Chang, Long-Sheng, Franco, Maria Clara, Fernandez-Valle, Cristina

“…Neurofibromatosis type 2 (NF2) is a nervous system tumor disorder caused by inactivation of the merlin tumor suppressor encoded by the gene. Bilateral…”
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Preclinical assessment of MEK1/2 inhibitors for neurofibromatosis type 2–associated schwannomas reveals differences in efficacy and drug resistance development by Fuse, Marisa A, Dinh, Christine T, Vitte, Jeremie, Kirkpatrick, Joanna, Mindos, Thomas, Plati, Stephani Klingeman, Young, Juan I, Huang, Jie, Carlstedt, Annemarie, Franco, Maria Clara, Brnjos, Konstantin, Nagamoto, Jackson, Petrilli, Alejandra M, Copik, Alicja J, Soulakova, Julia N, Bracho, Olena, Yan, Denise, Mittal, Rahul, Shen, Rulong, Telischi, Fred F, Morrison, Helen, Giovannini, Marco, Liu, Xue-Zhong, Chang, Long-Sheng, Fernandez-Valle, Cristina

“…Abstract Background Neurofibromatosis type 2 (NF2) is a genetic tumor-predisposition disorder caused by NF2/merlin tumor suppressor gene inactivation. The…”
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Tumor-Associated Macrophages in Vestibular Schwannoma and Relationship to Hearing by Nisenbaum, Eric, Misztal, Carly, Szczupak, Mikhaylo, Thielhelm, Torin, Peña, Stefanie, Mei, Christine, Goncalves, Stefania, Bracho, Olena, Ma, Ruixuan, Ivan, Michael E., Morcos, Jacques, Telischi, Fred, Liu, Xue-Zhong, Fernandez-Valle, Cristina, Dinh, Christine T.

“…Objective (1) Characterize the distribution of M1 and M2 macrophages in vestibular schwannomas by hearing status. (2) Develop assays to assess monocyte…”
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Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells by Petrilli, Alejandra M, Garcia, Jeanine, Bott, Marga, Klingeman Plati, Stephani, Dinh, Christine T, Bracho, Olena R, Yan, Denise, Zou, Bing, Mittal, Rahul, Telischi, Fred F, Liu, Xue-Zhong, Chang, Long-Sheng, Welling, D Bradley, Copik, Alicja J, Fernández-Valle, Cristina

“…Neurofibromatosis type 2 (NF2) is a genetic syndrome that predisposes individuals to multiple benign tumors of the central and peripheral nervous systems,…”
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Circumvention of Learning Increases Intoxication Efficacy of Nematicidal Engineered Bacteria by Bracho, Olena R, Manchery, Cyril, Haskell, Evan C, Blanar, Christopher A, Smith, Robert P

“…Synthetic biology holds promise to engineer systems to treat diseases. One critical, yet underexplored, facet of designing such systems is the interplay…”
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Modulation of BDNF–TRKB Interactions on Schwann Cell-induced Oral Squamous Cell Carcinoma Dispersion In Vitro by Ein, Liliana, Mei, Christine, Bracho, Olena, Bas, Esperanza, Monje, Paula, Weed, Donald, Sargi, Zoukaa, Thomas, Giovana, Dinh, Christine

“…Background/Aim: Perineural invasion (PNI) is a significant pathological feature in head and neck cancer. The molecular mechanisms of PNI are poorly understood…”
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Co-targeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells by Hardin, Haley M., Dinh, Christine T., Huegel, Julianne, Petrilli, Alejandra M., Bracho, Olena, Allaf, Abdulrahman, Karajannis, Matthias A., Griswold, Anthony J., Ivan, Michael E., Morcos, Jacques, Gultekin, Sakir H., Telischi, Fred F., Liu, Xue Zhong, Fernandez-Valle, Cristina

“…Neurofibromatosis Type 2 (NF2) is a tumor predisposition syndrome caused by germline inactivating mutations in the NF2 gene encoding the merlin tumor…”
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Abstract 4924: Evaluation of the efficacy of curcumin and Y15 in platinum resistant ovarian cancer cells by Levy, Arkene S., Rathinavelu, Appu, Coelho, Nicole, Ramnot, Amanda, Kanagasabai, Thanigaivelan, Bracho, Olena, Smith, Robert

“…Abstract Curcumin, a compound derived from turmeric (Curcuma longa), inhibits the proliferation of multiple cancer cell types, including ovarian, pulmonary,…”
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Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells by Hardin, Haley M, Dinh, Christine T, Huegel, Julianne, Petrilli, Alejandra M, Bracho, Olena, Allaf, Abdulrahman M, Karajannis, Matthias A, Griswold, Anthony J, Ivan, Michael E, Morcos, Jacques, Gultekin, Sakir H, Telischi, Fred F, Liu, Xue Zhong, Fernandez-Valle, Cristina

“…Neurofibromatosis Type 2 (NF2) is a tumor predisposition syndrome caused by germline inactivating mutations in the NF2 gene encoding the merlin tumor…”
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CUDC907, a dual phosphoinositide-3 kinase/histone deacetylase inhibitor, promotes apoptosis of NF2 Schwannoma cells by Huegel, Julianne, Dinh, Christine T, Martinelli, Maria, Bracho, Olena, Rosario, Rosa, Hardin, Haley, Estivill, Michael, Griswold, Anthony, Gultekin, Sakir, Liu, Xue-Zhong, Fernandez-Valle, Cristina

“…Neurofibromatosis Type 2 (NF2) is a rare tumor disorder caused by pathogenic variants of the merlin tumor suppressor encoded by . Patients develop vestibular…”
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Effect of AR42 in Primary Vestibular Schwannoma Cells and a Xenograft Model of Vestibular Schwannoma by Misztal, Carly, Bracho, Olena, Bas, Esperanza, Estivill, Michael, Ivan, Michael E., Morcos, Jacques, Bhatia, Rita, Telischi, Fred, Liu, Xue-Zhong, Gultekin, Sakir H., Fernandez-Valle, Cristina, Dinh, Christine T.

“…AR42, a histone deacetylase (HDAC) inhibitor, reduces viability of primary vestibular schwannoma (VS) cells and delays tumor progression and hearing loss (HL)…”
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Cytokine Profiling of Cyst Fluid and Tumor-Associated Macrophages in Cystic Vestibular Schwannoma by Nisenbaum, Eric, Wiefels, Matthew, Telischi, Julia, Marasigan, Mikhail, Kanumuri, Vivek, Pena, Stefanie, Thielhelm, Torin, Bracho, Olena, Bhatia, Rita, Scaglione, Tricia, Telischi, Fred, Fernandez-Valle, Cristina, Liu, Xue-Zhong, Luther, Evan, Morcos, Jacques, Ivan, Michael, Dinh, Christine T

“…The vestibular schwannoma (VS) secretome can initiate monocyte recruitment and macrophage polarization to M1 (proinflammatory) and/or M2 (protumorigenic)…”
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Fluorescent Detection of Vestibular Schwannoma Using Intravenous Sodium Fluorescein In Vivo by Szczupak, Mikhaylo, Peña, Stefanie A., Bracho, Olena, Mei, Christine, Bas, Esperanza, Fernandez-Valle, Cristina, Liu, Xue-Zhong, Telischi, Fred F., Ivan, Michael, Dinh, Christine T.

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Fluorescent Detection of Vestibular Schwannoma Using Intravenous Sodium Fluorescein In Vivo by Szczupak, Mikhaylo, Peña, Stefanie A., Bracho, Olena, Mei, Christine, Bas, Esperanza, Fernandez-Valle, Cristina, Liu, Xue-Zhong, Telischi, Fred F., Ivan, Michael, Dinh, Christine T.

“…Vestibular schwannoma (VS) are intracranial tumors caused by merlin deficiency. Sodium fluorescein (SF) is a fluorescent compound that accumulates in various…”
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RAD51 Inhibitor and Radiation Toxicity in Vestibular Schwannoma by Thielhelm, Torin P., Nourbakhsh, Aida, Welford, Scott M., Mellon, Eric A., Bracho, Olena, Ivan, Michael E., Telischi, Fred, Fernandez-Valle, Cristina, Dinh, Christine T.

“…Objective To describe the RAD51 response (DNA repair) to radiation-induced DNA damage in patient-derived vestibular schwannoma (VS) cells and investigate the…”
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Abstract 1860: MDM2 stabilizes and induces HIF-1α levels during reoxygenation of cancer cells by Kanagasabai, Thanigaivelan, Chand, Rohin, Kaur, AmyAman, Dhandayuthapani, Sivanesan, Bracho, Olena, Rathinavelu, Appu

“…Abstract Hypoxia stimulates several pathways that are critical to cancer cell growth and survival, including activation of vascular endothelial growth factor…”
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A Xenograft Model of Vestibular Schwannoma and Hearing Loss by Dinh, Christine T, Bracho, Olena, Mei, Christine, Bas, Esperanza, Fernandez-Valle, Cristina, Telischi, Fred, Liu, Xue-Zhong

“…HYPOTHESIS:Microsurgical implantation of mouse merlin-deficient Schwann cells (MD-SC) into the cerebellopontine angle of immunodeficient rats will initiate…”
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Primary Vestibular Schwannoma Cells Activate p21 and RAD51-Associated DNA Repair Following Radiation-Induced DNA Damage by Thielhelm, Torin P., Goncalves, Stefania, Welford, Scott, Mellon, Eric A., Bracho, Olena, Estivill, Michael, Brown, Clifford, Morcos, Jacques, Ivan, Michael E., Telischi, Fred, Fernandez-Valle, Cristina, Dinh, Christine T.

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Inhibition of tropomyosine receptor kinase B on the migration of human Schwann cell and dispersion of oral tongue squamous cell carcinoma in vitro by Ein, Liliana, Bracho, Olena, Mei, Christine, Patel, Jaimin, Boyle, Thomas, Monje, Paula, Fernandez‐Valle, Cristina, Bas, Esperanza, Thomas, Giovana, Weed, Donald, Sargi, Zoukaa, Dinh, Christine

“…Background Schwann cells (SC) may play an important role in perineural invasion (PNI) by promoting cancer cell dispersion. Brain‐derived neurotrophic factor…”
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