Search Results - "Brace, E J"

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2 by Walker, Lauren J, Summers, Daniel W, Sasaki, Yo, Brace, E J, Milbrandt, Jeffrey, DiAntonio, Aaron

“…Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and…”
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Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity by Brace, E. J., Essuman, Kow, Mao, Xianrong, Palucki, John, Sasaki, Yo, Milbrandt, Jeff, DiAntonio, Aaron

“…SARM1 is the founding member of the TIR-domain family of NAD + hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent…”
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SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury by Brace, E J, Wu, Chunlai, Valakh, Vera, DiAntonio, Aaron

“…The Wallenda (Wnd)/dual leucine zipper kinase (DLK)-Jnk pathway is an evolutionarily conserved MAPK signaling pathway that functions during neuronal…”
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The E3 ligase Highwire promotes synaptic transmission by targeting the NAD‐synthesizing enzyme dNmnat by Russo, Alexandra, Goel, Pragya, Brace, EJ, Buser, Chris, Dickman, Dion, DiAntonio, Aaron

“…The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila . Highwire regulates synaptic…”
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SARM1 activation triggers axon degeneration locally via NAD+destruction by Gerdts, Josiah, Brace, E.J., Sasaki, Yo, DiAntonio, Aaron, Milbrandt, Jeffrey

“…Axon degeneration is an intrinsic self-destruction program that underlies axon loss during injury and disease. Sterile alpha and TIR motif–containing 1 (SARM1)…”
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Models of axon regeneration in Drosophila by Brace, E.J., DiAntonio, Aaron

“…Maintaining neuronal connectivity in the face of injury and disease is a major challenge for the nervous system. The great length of axons makes them…”
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Models of Axon Degeneration in Drosophila Larvae by Brace, E J, DiAntonio, Aaron

“…The fruit fly Drosophila melanogaster has been a powerful model to study axonal biology including axon degeneration and regeneration (Brace et al., J Neurosci…”
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The scaffold protein POSH regulates axon outgrowth by Taylor, Jennifer, Chung, Kwan-Ho, Figueroa, Claudia, Zurawski, Jonathan, Dickson, Heather M, Brace, E J, Avery, Adam W, Turner, David L, Vojtek, Anne B

“…How scaffold proteins integrate signaling pathways with cytoskeletal components to drive axon outgrowth is not well understood. We report here that the…”
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Skp1p Regulates Soi3p/Rav1p Association with Endosomal Membranes but Is Not Required for Vacuolar ATPase Assembly by Brace, E J, Parkinson, Leah P, Fuller, Robert S

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins by Sipos, György, Brickner, Jason H, Brace, E J, Chen, Linyi, Rambourg, Alain, Kepes, Francois, Fuller, Robert S

“…SOI3 was identified by a mutation, soi3-1, that suppressed a mutant trans-Golgi network (TGN) localization signal in the Kex2p cytosolic tail. SOI3, identical…”
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Trapping, detection and reaction of very large single molecular ions by mass spectrometry by Smith, R. D, Cheng, X, Brace, J. E, Hofstadler, S. A, Anderson, G. A

“…Electrospray-ionization (ESI) mass spectrometry is an important technique for measuring molecular weights and studying the structures of large molecules of…”
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