Search Results - "Brabander, Justin"

Age-related changes in plasma biomarkers and their association with mortality in COVID-19 by Michels, Erik H A, Appelman, Brent, de Brabander, Justin, van Amstel, Rombout B E, Chouchane, Osoul, van Linge, Christine C A, Schuurman, Alex R, Reijnders, Tom D Y, Sulzer, Titia A L, Klarenbeek, Augustijn M, Douma, Renée A, Bos, Lieuwe D J, Wiersinga, W Joost, Peters-Sengers, Hessel, van der Poll, Tom, van Agtmael, Michiel, Algera, Anne Geke, Appelman, Brent, van Baarle, Floor, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Bugiani, Marianna, Bulle, Esther, Buis, David T P, Chouchane, Osoul, Cloherty, Alex, Dijkstra, Mirjam, Dongelmans, Dave A, Dujardin, Romein W G, Elbers, Paul, Fleuren, Lucas, Geerlings, Suzanne, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M, Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W, de Jong, Hanna K, de Jong, Menno D, Koning, Rutger, Lemkes, Bregje, Lim, Endry H T, van Mourik, Niels, Nellen, Jeaninne, Nossent, Esther J, Olie, Sabine, Paulus, Frederique, Peters, Edgar, Pina-Fuentes, Dan A I, van der Poll, Tom, Preckel, Bennedikt, Prins, Jan M, Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C F J, Schinkel, Michiel, Schultz, Marcus J, Schrauwen, Femke A P, Schuurman, Alex, Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A, Smeele, Patrick, Smit, Marry, Stijnis, Cornelis S, Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa M, Tuinman, Pieter R, van der Valk, Marc, Veelo, Denise P, Volleman, Carolien, de Vries, Heder, Vught, Lonneke A, van Vugt, Michèle, Wouters, Dorien, Zwinderman, A H Koos, Brouwer, Matthijs C, Wiersinga, W Joost, Vlaar, Alexander P J, van de Beek, Diederik

“…Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these…”
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Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia by Schuurman, Alex R, Reijnders, Tom DY, Saris, Anno, Ramirez Moral, Ivan, Schinkel, Michiel, de Brabander, Justin, van Linge, Christine, Vermeulen, Louis, Scicluna, Brendon P, Wiersinga, W Joost, Vieira Braga, Felipe A, van der Poll, Tom

“…The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease…”
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Intramuscular adipose tissue at level Th12 is associated with survival in COVID‐19 by Viddeleer, Alain R., Raaphorst, Joost, Min, Minoesch, Beenen, Ludo F.M., Scheerder, Maeke J., Vlaar, Alexander P.J., Beudel, Martijn, Hemke, Robert, Bruin, Sanne, Schuurmans, Alex, Koning, Rutger, Agtmael, Michiel, Algera, Anne Geke, Baarle, Frank, Bax, Diane, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, Brabander, Justin, Bree, Godelieve, Bugiani, Marianna, Bulle, Esther, Chouchane, Osoul, Cloherty, Alex, Dongelmans, Dave A., Elbers, Paul, Fleuren, Lucas, Geerlings, Suzanne, Geerts, Bart, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., Jong, Menno D., Mourik, Niels, Nossent, Esther J., Nellen, Jeaninne, Paulus, Frederique, Reijnders, Tom, Peters, Edgar, Poll, Tom, Preckel, Bennedikt, Prins, Jan M., Raasveld, Jorinde, Schinkel, Michiel, Schultz, Marcus J., Sigaloff, Kim, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa, Valk, Marc, Veelo, Denise, Vries, Heder, Vugt, Michèle, Wouters, Dorien, Zwinderman, A. H (Koos), Brouwer, Matthijs C., Wiersinga, W. Joost, Vlaar, Alexander P.J., Beek, Diederik

“…Sarcopenia, as an example of abnormal body composition, is defined as a significant loss of skeletal muscle mass (muscle wasting) and muscle strength and…”
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Proteomic profiling of neutrophils and plasma in community-acquired pneumonia reveals crucial proteins in diverse biological pathways linked to clinical outcome by Michels, Erik H. A., Chouchane, Osoul, de Brabander, Justin, de Vos, Alex F., Faber, Daniël R., Douma, Renée A., Smit, Eva R., Wiersinga, W. Joost, Biggelaar, Maartje van den, Poll, Tom van der, Hoogendijk, Arie J.

“…Neutrophils play a dichotomous role in community-acquired pneumonia (CAP), providing protection and potentially causing damage. Existing research on neutrophil…”
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25-Hydroxyvitamin D concentrations do not affect the humoral or cellular immune response following SARS-CoV-2 mRNA vaccinations by Lavell, A.H.A., Schramade, A.E., Sikkens, J.J., van der Straten, K., van Dort, K.A., Slim, M.A., Appelman, B., van Vught, L.A., Vlaar, A.P.J., Kootstra, N.A., van Gils, M.J., Smulders, Y.M., de Jongh, R.T., Bomers, M.K., Appelman, Brent, Beek van de, Diederik, Bomers, Marije K., Brabander de, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, Gils van, Marit J., Jong de, Menno D., Lavell, Ayesha H.A., Mourik van, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Straten van der, Karlijn, Smulders, Yvo M., Vlaar, Alexander P.J., Vught van, Lonneke A., Wiersinga, W. Joost

“…•BNT162b2 or mRNA-1273 induced antibodies are not affected by 25(OH)D concentration.•BNT162b2 induced T cell responses are not associated with 25(OH)D…”
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Pre-PCI versus immediate post-PCI Impella initiation in acute myocardial infarction complicated by cardiogenic shock by Hemradj, Veemal V, Karami, Mina, Sjauw, Krischan D, Engström, Annemarie E, Ouweneel, Dagmar M, de Brabander, Justin, Vis, Marije M, Wykrzykowska, Joanna J, Beijk, Marcel A, Koch, Karel T, Baan, Jan, de Winter, Robbert J, Piek, Jan J, Driessen, Antoine H. G, Lagrand, Wim K, Vlaar, Alexander P. J, Ottervanger, Jan Paul, Henriques, José P. S

“…Background In selected patients with an acute myocardial infarction (AMI) complicated by Cardiogenic shock (CS), mechanical circulatory support with Impella…”
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Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward by de Brabander, Justin, Michels, Erik H A, van Linge, Christine C A, Chouchane, Osoul, Douma, Renée A, Reijnders, Tom D Y, Schuurman, Alex R, van Engelen, Tjitske S R, Wiersinga, W Joost, van der Poll, Tom

“…Dexamethasone improves clinical outcomes in COVID-19 patients requiring supplementary oxygen. We investigated possible mechanisms of action by comparing…”
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The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees by Van Coillie, Julie, Pongracz, Tamas, Rahmöller, Johann, Chen, Hung-Jen, Geyer, Chiara Elisabeth, van Vught, Lonneke A., Buhre, Jana Sophia, Šuštić, Tonći, van Osch, Thijs Luc Junior, Steenhuis, Maurice, Hoepel, Willianne, Wang, Wenjun, Lixenfeld, Anne Sophie, Nouta, Jan, Keijzer, Sofie, Linty, Federica, Visser, Remco, Larsen, Mads Delbo, Martin, Emily Lara, Künsting, Inga, Lehrian, Selina, von Kopylow, Vera, Kern, Carsten, Lunding, Hanna Bele, de Winther, Menno, van Mourik, Niels, Rispens, Theo, Graf, Tobias, Slim, Marleen Adriana, Minnaar, René Peter, Bomers, Marije Kristianne, Sikkens, Jonne Jochum, Vlaar, Alexander P.J., van der Schoot, C. Ellen, den Dunnen, Jeroen, Wuhrer, Manfred, Ehlers, Marc, Vidarsson, Gestur, Antinori, Spinello, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W.

“…Afucosylated IgG1 responses have only been found against membrane-embedded epitopes, including anti-S in SARS-CoV-2 infections. These responses, intrinsically…”
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The host response in different aetiologies of community-acquired pneumonia by Schuurman, Alex R., Reijnders, Tom D.Y., van Engelen, Tjitske S.R., Léopold, Valentine, de Brabander, Justin, van Linge, Christine, Schinkel, Michiel, Pereverzeva, Liza, Haak, Bastiaan W., Brands, Xanthe, Kanglie, Maadrika M.N.P., van den Berk, Inge A.H., Douma, Renée A., Faber, Daniël R., Nanayakkara, Prabath W.B., Stoker, Jaap, Prins, Jan M., Scicluna, Brendon P., Wiersinga, W. Joost, van der Poll, Tom

“…Community-acquired pneumonia (CAP) can be caused by a variety of pathogens, of which Streptococcus pneumoniae, Influenza and currently SARS-CoV-2 are the most…”
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Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines by Van Coillie, Julie, Pongracz, Tamas, Šuštić, Tonći, Wang, Wenjun, Nouta, Jan, Le Gars, Mathieu, Keijzer, Sofie, Linty, Federica, Cristianawati, Olvi, Keijser, Jim B.D., Visser, Remco, van Vught, Lonneke A., Slim, Marleen A., van Mourik, Niels, Smit, Merel J., Sander, Adam, Schmidt, David E., Steenhuis, Maurice, Rispens, Theo, Nielsen, Morten A., Mordmüller, Benjamin G., Vlaar, Alexander P.J., Ellen van der Schoot, C., Roozendaal, Ramon, Wuhrer, Manfred, Vidarsson, Gestur, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, de Jongh, Willem A., Salanti, Ali, Theander, Thor G., McCall, Matthew B.B., Esen, Meral

“…IgG antibodies are important mediators of vaccine-induced immunity through complement- and Fc receptor-dependent effector functions. Both are influenced by the…”
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Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients by Koning, Rutger, Bastard, Paul, Casanova, Jean-Laurent, Brouwer, Matthijs C., van de Beek, Diederik

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Microbial Burden-associated Cytokine Storm May Explain Nonresolving Acute Respiratory Distress Syndrome in Patients with COVID-19 / Reply by Yasuma, Taro, D'Alessandro-Gabazza, Corina N, Kobayashi, Tetsu, Gabazza, Esteban C, Fujimoto, Hajime, Kullberg, Robert F J, de Brabander, Justin, Boers, Leonoor S, Bos, Lieuwe D J, Wiersinga, W Joost

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Reply to: Microbial Burden-associated Cytokine Storm May Explain Non-Resolving ARDS in COVID-19 Patients by Kullberg, Robert F J, de Brabander, Justin, Boers, Leonoor S, Bos, Lieuwe D J, Wiersinga, W Joost

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Indoleamine 2,3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19 by Guo, Lihui, Schurink, Bernadette, Roos, Eva, Nossent, Esther J, Duitman, Jan Willem, Vlaar, Alexander PJ, Valk, Paul, Vaz, Frédéric M, Yeh, Syun‐Ru, Geeraerts, Zachary, Dijkhuis, Annemiek, Vught, Lonneke, Bugiani, Marianna, Lutter, René

“…COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19 patients, we found extensive accumulation of the tryptophan…”
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Monocyte state 1 (MS1) cells in critically ill patients with sepsis or non-infectious conditions: association with disease course and host response by Leite, Giuseppe G F, de Brabander, Justin, Michels, Erik H A, Butler, Joe M, Cremer, Olaf L, Scicluna, Brendon P, Sweeney, Timothy E, Reyes, Miguel, Salomao, Reinaldo, Peters-Sengers, Hessel, van der Poll, Tom

“…Sepsis is a life-threatening condition arising from an aberrant host response to infection. Recent single-cell RNA sequencing investigations identified an…”
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Immunomodulation and endothelial barrier protection mediate the association between oral imatinib and mortality in hospitalised COVID-19 patients by de Brabander, Justin, Duijvelaar, Erik, Schippers, Job R, Smeele, Patrick J, Peters-Sengers, Hessel, Duitman, Jan Willem, Aman, Jurjan, Bogaard, Harm Jan, van der Poll, Tom, Bos, Lieuwe D J

“…Imatinib reduced 90-day mortality in hospitalised coronavirus disease 2019 (COVID-19) patients in a recent clinical trial, but the biological effects that…”
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Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia by Michels, Erik H A, Appelman, Brent, de Brabander, Justin, van Amstel, Rombout B E, van Linge, Christine C A, Chouchane, Osoul, Reijnders, Tom D Y, Schuurman, Alex R, Sulzer, Titia A L, Klarenbeek, Augustijn M, Douma, Renée A, Bos, Lieuwe D J, Wiersinga, W Joost, Peters-Sengers, Hessel, van der Poll, Tom

“…Lymphopenia in coronavirus disease (COVID-19) is associated with increased mortality. To explore the association between lymphopenia, host response…”
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Lung Microbiota of Critically Ill Patients with COVID-19 Are Associated with Nonresolving Acute Respiratory Distress Syndrome by Kullberg, Robert F J, de Brabander, Justin, Boers, Leonoor S, Biemond, Jason J, Nossent, Esther J, Heunks, Leo M A, Vlaar, Alexander P J, Bonta, Peter I, van der Poll, Tom, Duitman, JanWillem, Bos, Lieuwe D J, Wiersinga, W Joost

“…Bacterial lung microbiota are correlated with lung inflammation and acute respiratory distress syndrome (ARDS) and altered in severe coronavirus disease…”
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The alveolar fibroproliferative response in moderate to severe COVID-19-related acute respiratory distress syndrome and 1-yr follow-up by Zhang, Shiqi, Boers, Leonoor S, de Brabander, Justin, van den Heuvel, Laura B, Blok, Siebe G, Kullberg, Robert F J, Smids-Dierdorp, Barbara S, Dekker, Tamara, Aberson, Hella L, Meijboom, Lilian J, Vlaar, Alexander P J, Heunks, Leo, Nossent, Esther J, van der Poll, Tom, Bos, Lieuwe D J, Duitman, JanWillem

“…COVID-19-related acute respiratory distress syndrome (ARDS) can lead to long-term pulmonary fibrotic lesions. Alveolar fibroproliferative response (FPR) is a…”
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Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia by Philippot, Quentin, Fekkar, Arnaud, Gervais, Adrian, Le Voyer, Tom, Boers, Leonoor S., Conil, Clément, Bizien, Lucy, de Brabander, Justin, Duitman, Jan Willem, Romano, Alessia, Rosain, Jérémie, Blaize, Marion, Migaud, Mélanie, Jeljeli, Maxime, Hammadi, Boualem, Desmons, Aurore, Marchal, Astrid, Mayaux, Julien, Zhang, Qian, Jouanguy, Emmanuelle, Borie, Raphael, Crestani, Bruno, Luyt, Charles Edouard, Adle-Biassette, Homa, Sene, Damien, Megarbane, Bruno, Cobat, Aurélie, Bastard, Paul, Bos, Lieuwe D. J., Casanova, Jean-Laurent, Puel, Anne

“…Autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) are found in the blood of at least 15% of unvaccinated patients with life-threatening COVID-19…”
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