Search Results - "Braasch, Dwaine A."

RNA Interference in Mammalian Cells by Chemically-Modified RNA by Braasch, Dwaine A, Jensen, Susan, Liu, Yinghui, Kaur, Kiran, Arar, Khalil, White, Michael A, Corey, David R

“…RNA interference (RNAi) is proving to be a robust and versatile technique for controlling gene expression in mammalian cells. To fully realize its potential in…”
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Biodistribution of phosphodiester and phosphorothioate siRNA by BRAASCH, Dwaine A, PAROO, Zain, CONSTANTINESCU, Anca, GANG REN, ÖZ, Orhan K, MASON, Ralph P, COREY, David R

“…Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led to high expectations for in…”
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Implications of High-Affinity Hybridization by Locked Nucleic Acid Oligomers for Inhibition of Human Telomerase by Elayadi, Anissa N, Braasch, Dwaine A, Corey, David R

“…Oligonucleotides that contain locked nucleic acid (LNA) bases have remarkably high affinity for complementary RNA and DNA sequences. This increased affinity…”
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Detection of in Situ Early Corrosion on Polymer-Coated Metal Substrates by Braasch, Dwaine A, Gillis, Mathew, Pramanik, Monoj, Ferguson, Richard C, Delatte, David, Blanton, Michael, Rawlins, James Wayne

“…Protective coating systems (PCS) are a common and facile method to protect metal substrates from corrosion. The corrosion control performance of polymer-coated…”
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Lumenal adenosine and AMP rapidly increase glucose transport by intact small intestine by Kimura, Yasuhiro, Turner, Jerrold R, Braasch, Dwaine A, Buddington, Randal K

“…Adenosine modulates the intestinal functions of secretion, motility, and immunity, yet little is known about the regulation of nutrient absorption. Therefore,…”
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Enhanced Strand Invasion by Peptide Nucleic Acid−Peptide Conjugates by Kaihatsu, Kunihiro, Braasch, Dwaine A, Cansizoglu, Ahmet, Corey, David R

“…Efficient and selective recognition of DNA by proteins is due to sequence-specific interactions with a target site and nonselective electrostatic interactions…”
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Use of Fluorescent Probes to Determine Molecular Architecture in Phase Separating Epoxy Systems by Davis, Kevin B, Braasch, Dwaine A, Pramanik, Monoj, Rawlins, James W

“…A novel route for morphological characterization of phase separating toughener and cross-linker for epoxy matrices has been investigated using fluorescence…”
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Degradation of ricin in castor seed meal by temperature and chemical treatment by Barnes, Daniel J., Baldwin, Brian S., Braasch, Dwaine A.

“…Oil from the seed of the castor plant ( Ricinus communis L.) is an important commodity for a number of industries, ranging from pharmaceuticals to renewable…”
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Destruction of Opportunistic Pathogens via Polymer Nanoparticle-Mediated Release of Plant-Based Antimicrobial Payloads by Amato, Dahlia N., Amato, Douglas V., Mavrodi, Olga V., Braasch, Dwaine A., Walley, Susan E., Douglas, Jessica R., Mavrodi, Dmitri V., Patton, Derek L.

“…The synthesis of antimicrobial thymol/carvacrol‐loaded polythioether nanoparticles (NPs) via a one‐pot, solvent‐free miniemulsion thiol‐ene photopolymerization…”
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Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design by Braasch, Dwaine A., Liu, Yinghui, Corey, David R.

“…Use of antisense oligonucleotides is a versatile strategy for achieving control of gene expression. Unfortunately, the interpretation of antisense‐induced…”
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Ricin accumulation and degradation during castor seed development and late germination by Barnes, Daniel J., Baldwin, Brian S., Braasch, Dwaine A.

“…The castor plant ( Ricinus communis L.) is a euphorb, commonly grown for its high seed oil content. The seed also contains a deadly toxin known as ricin (RCA…”
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Novel Antisense and Peptide Nucleic Acid Strategies for Controlling Gene Expression by Braasch, Dwaine A, Corey, David R

“…Antisense oligonucleotides have the potential to make revolutionary contributions to basic science and medicine. Oligonucleotides can bind mRNA and inhibit…”
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Using Aldehyde Synergism To Direct the Design of Degradable Pro-Antimicrobial Networks by Amato, Dahlia N, Amato, Douglas V, Adewunmi, Yetunde, Mavrodi, Olga V, Parsons, Keith H, Swilley, Sarah N, Braasch, Dwaine A, Walker, William D, Mavrodi, Dmitri V, Patton, Derek L

“…We describe the design and synthesis of degradable, dual-release, pro-antimicrobial poly­(thioether acetal) networks derived from synergistic pairs of aromatic…”
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Validating bioluminescence imaging as a high-throughput, quantitative modality for assessing tumor burden by Paroo, Zain, Bollinger, Robert A, Braasch, Dwaine A, Richer, Edmond, Corey, David R, Antich, Peter P, Mason, Ralph P

“…Bioluminescence imaging (BLI) is a highly sensitive tool for visualizing tumors, neoplastic development, metastatic spread, and response to therapy. Although…”
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Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA by Braasch, Dwaine A, Corey, David R

“…Locked nucleic acid is an RNA derivative in which the ribose ring is constrained by a methylene linkage between the 2′-oxygen and the 4′-carbon. This…”
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Inhibition of Gene Expression Inside Cells by Peptide Nucleic Acids:  Effect of mRNA Target Sequence, Mismatched Bases, and PNA Length by Doyle, Donald F, Braasch, Dwaine A, Janowski, Bethany A, Corey, David R

“…Genome sequencing has revealed thousands of novel genes, placing renewed emphasis on chemical approaches for controlling gene expression. Antisense oligomers…”
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Synthesis and purification of peptide nucleic acids by Braasch, Dwaine A, Nulf, Christopher J, Corey, David R

“…Peptide nucleic acids (PNAs) are DNA analogs in which the normal phosphodiester backbone is replaced by 2-aminoethyl glycine linkages. Hybridization of PNAs…”
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Imaging Gene Expression in the Brain In Vivo in a Transgenic Mouse Model of Huntington's Disease with an Antisense Radiopharmaceutical and Drug-Targeting Technology by Lee, Hwa Jeong, Boado, Ruben J, Braasch, Dwaine A, Corey, David R, Pardridge, William M

“…Disease-specific genes of unknown function can be imaged in vivo with antisense radiopharmaceuticals, providing the transcellular transport of these molecules…”
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Efficient and Isoform-Selective Inhibition of Cellular Gene Expression by Peptide Nucleic Acids by Liu, Yinghui, Braasch, Dwaine A, Nulf, Christopher J, Corey, David R

“…Peptide nucleic acids (PNAs) are a potentially powerful approach for the recognition of cellular mRNA and the inhibition of gene expression. Despite their…”
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Lipid-mediated introduction of peptide nucleic acids into cells by Braasch, Dwaine A, Corey, David R

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