Search Results - "Braam, R."

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes by Braam, Stefan R, Tertoolen, Leon, van de Stolpe, Anja, Meyer, Thomas, Passier, Robert, Mummery, Christine L

“…Recent withdrawals of prescription drugs from clinical use because of unexpected side effects on the heart have highlighted the need for more reliable cardiac…”
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A prospective validation of the HEART score for chest pain patients at the emergency department by Backus, B.E, Six, A.J, Kelder, J.C, Bosschaert, M.A.R, Mast, E.G, Mosterd, A, Veldkamp, R.F, Wardeh, A.J, Tio, R, Braam, R, Monnink, S.H.J, van Tooren, R, Mast, T.P, van den Akker, F, Cramer, M.J.M, Poldervaart, J.M, Hoes, A.W, Doevendans, P.A

“…Abstract Background The focus of the diagnostic process in chest pain patients at the emergency department is to identify both low and high risk patients for…”
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Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells by Van Hoof, Dennis, Muñoz, Javier, Braam, Stefan R., Pinkse, Martijn W.H., Linding, Rune, Heck, Albert J.R., Mummery, Christine L., Krijgsveld, Jeroen

“…Pluripotent stem cells self-renew indefinitely and possess characteristic protein-protein networks that remodel during differentiation. How this occurs is…”
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Recognition of cognitive impairment and depressive symptoms in older patients with heart failure by Oud, F. M. M., Spies, P. E., Braam, R. L., van Munster, B. C.

“…Introduction Cognitive impairment and depression in patients with heart failure (HF) are common comorbidities and are associated with increased morbidity,…”
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Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK by Graichen, Ralph, Xu, Xiuqin, Braam, Stefan R., Balakrishnan, Thavamalar, Norfiza, Siti, Sieh, Shirly, Soo, Set Yen, Tham, Su Chin, Mummery, Christine, Colman, Alan, Zweigerdt, Robert, Davidson, Bruce P.

“…Human embryonic stem cells (hESC) can differentiate to cardiomyocytes in vitro but with generally poor efficiency. Here, we describe a novel method for the…”
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Intracavitary course of right coronary artery by Bouhuijzen, L. J., Kardux, J. J., Braam, R. L.

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Nuclear myocardial perfusion imaging in stable angina pectoris: Sometimes being wrong is all right by Dedic, A., Braam, R. L.

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Plasma Membrane Proteomics of Human Embryonic Stem Cells and Human Embryonal Carcinoma Cells by Dormeyer, Wilma, van Hoof, Dennis, Braam, Stefan R, Heck, Albert J. R, Mummery, Christine L, Krijgsveld, Jeroen

“…Human embryonic stem cells (hESCs) are of immense interest in regenerative medicine as they can self-renew indefinitely and can give rise to any adult cell…”
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Feeder-free culture of human embryonic stem cells in conditioned medium for efficient genetic modification by Denning, Chris, Mummery, Christine L, Braam, Stefan R, Matsa, Elena, Young, Lorraine E, Passier, Robert

“…Realizing the potential of human embryonic stem cells (hESCs) in research and commercial applications requires generic protocols for culture, expansion and…”
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Differences at surgery between patients with bicuspid and tricuspid aortic valves by Cozijnsen, L., van der Zaag-Loonen, H. J., Cozijnsen, M. A., Braam, R. L., Heijmen, R. H., Bouma, B. J., Mulder, B. J. M.

“…Aim To determine differences in surgical procedures and clinical characteristics at the time of surgery between native bicuspid aortic valves (BAV) and…”
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Family screening in patients with isolated bicuspid aortic valve: Restriction to those with aortic dilatation is not justified by Cozijnsen, L., Braam, R. L., Bakker-de Boo, M., Otten, A. M., Post, J. G., Schermer, T., Bouma, B. J., Mulder, B. J. M.

“…Aim To determine the prevalence of undiagnosed bicuspid aortic valve (BAV) and isolated aortic dilatation in first-degree relatives (FDRs) of patients with…”
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Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models by Kraushaar, Udo, Meyer, Thomas, Hess, Dietmar, Gepstein, Lior, Mummery, Christine L, Braam, Stefan R, Guenther, Elke

“…The field of cardiac safety pharmacology has been experiencing exciting changes over the recent years. Drug induced arrhythmia of the torsade des pointes types…”
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Addition of FFRct in the diagnostic pathway of patients with stable chest pain to reduce unnecessary invasive coronary angiography (FUSION): Rationale and design for the multicentre, randomised, controlled FUSION trial by Sharma, S. P., Hirsch, A., Hunink, M. G. M., Cramer, M. J. M., Mohamed Hoesein, F. A. A., Geluk, C. A., Kramer, G., Gratama, J. W. C., Braam, R. L., van der Zee, P. M., Yassi, W., Wolters, S. L., Gürlek, C., Pundziute, G., Vliegenthart, R., Budde, R. P. J.

“…Background Coronary computed tomography angiography (CCTA) is widely used in the diagnostic work-up of patients with stable chest pain. CCTA has an excellent…”
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Enhancement of polymeric immunoglobulin receptor transcytosis by biparatopic VHH by Emmerson, Chris D, van der Vlist, Els J, Braam, Myrthe R, Vanlandschoot, Peter, Merchiers, Pascal, de Haard, Hans J W, Verrips, C Theo, van Bergen en Henegouwen, Paul M P, Dolk, Edward

“…The polymeric immunoglobulin receptor (pIgR) ensures the transport of dimeric immunoglobulin A (dIgA) and pentameric immunoglobulin M (pIgM) across epithelia…”
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Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation by Braam, Stefan R., Nauw, Roy, Ward-van Oostwaard, Dorien, Mummery, Christine, Passier, Robert

“…In recent years the differentiation efficiency of human embryonic stem cells (hESCs) to cardiomyocytes has improved considerably. In general, hESC‐derived…”
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Prognostic factors in infective endocarditis in general hospitals in the Netherlands by van den Brink, F., Hasenaar, J., Winia, V., Klomp, M., Van Vlies, B., Nicastia, D., Groenmeijer, B., Braam, R., Jaarsma, W., Funke Kupper, A. J.

“…Introduction Despite advances in treatment, infective endocarditis (IE) still ranks amongst the most lethal infectious diseases. We sought to determine…”
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Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes by Braam, S R, Tertoolen, L, Casini, S, Matsa, E, Lu, H R, Teisman, A, Passier, R, Denning, C, Gallacher, D J, Towart, R, Mummery, C L

“…Unexpected induction of arrhythmias in the heart is still one of the major risks of new drugs despite recent improvements in cardiac safety assays. Here we…”
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Feeder‐Free Monolayer Cultures of Human Embryonic Stem Cells Express an Epithelial Plasma Membrane Protein Profile by Van Hoof, Dennis, Braam, Stefan R., Dormeyer, Wilma, Ward‐van Oostwaard, Dorien, Heck, Albert J.R., Krijgsveld, Jeroen, Mummery, Christine L.

“…Human embryonic stem cells (hESCs) are often cocultured on mitotically inactive fibroblast feeder cells to maintain their undifferentiated state. Under these…”
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The vertical ground reaction force and the pressure distribution on the claws of dairy cows while walking on a flat substrate by van der Tol, P P J, Metz, J H M, Noordhuizen-Stassen, E N, Back, W, Braam, C R, Weijs, W A

“…The pressure distribution under the bovine claw while walking was measured to test the hypotheses that the vertical ground reaction force is unevenly…”
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Frictional forces required for unrestrained locomotion in dairy cattle by van der Tol, P P J, Metz, J H M, Noordhuizen-Stassen, E N, Back, W, Braam, C R, Weijs, W A

“…Most free-stall housing systems in the Netherlands are equipped with slatted or solid concrete floors with manure scrapers. A slipping incident occurs when the…”
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