Search Results - "Braam, Mitchell J.S."

A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell–derived Islets by Ramzy, Adam, Belmonte, Paul J, Braam, Mitchell J S, Ida, Shogo, Wilts, Emily M, Levings, Megan K, Rezania, Alireza, Kieffer, Timothy J

“…Abstract For the past century, insulin injections have saved millions of lives, but glycemic instability is still a persistent challenge for people with…”
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SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling by Oudhoff, Menno J., Braam, Mitchell J.S., Freeman, Spencer A., Wong, Denise, Rattray, David G., Wang, Jia, Antignano, Frann, Snyder, Kimberly, Refaeli, Ido, Hughes, Michael R., McNagny, Kelly M., Gold, Michael R., Arrowsmith, Cheryl H., Sato, Toshiro, Rossi, Fabio M.V., Tatlock, John H., Owen, Dafydd R., Brown, Peter J., Zaph, Colby

“…Intestinal tumorigenesis is a result of mutations in signaling pathways that control cellular proliferation, differentiation, and survival. Mutations in the…”
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Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation by Antignano, Frann, Burrows, Kyle, Hughes, Michael R, Han, Jonathan M, Kron, Ken J, Penrod, Nadia M, Oudhoff, Menno J, Wang, Steven Kai Hao, Min, Paul H, Gold, Matthew J, Chenery, Alistair L, Braam, Mitchell J S, Fung, Thomas C, Rossi, Fabio M V, McNagny, Kelly M, Arrowsmith, Cheryl H, Lupien, Mathieu, Levings, Megan K, Zaph, Colby

“…Inflammatory bowel disease (IBD) pathogenesis is associated with dysregulated CD4⁺ Th cell responses, with intestinal homeostasis depending on the balance…”
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Human A2-CAR T Cells Reject HLA-A2 + Human Islets Transplanted Into Mice Without Inducing Graft-versus-host Disease by Ellis, Cara E, Mojibian, Majid, Ida, Shogo, Fung, Vivian C W, Skovsø, Søs, McIver, Emma, O'Dwyer, Shannon, Webber, Travis D, Braam, Mitchell J S, Saber, Nelly, Sasaki, Shugo, Lynn, Francis C, Kieffer, Timothy J, Levings, Megan K

“…Type 1 diabetes is an autoimmune disease characterized by T-cell-mediated destruction of pancreatic beta-cells. Islet transplantation is an effective therapy,…”
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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells by Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.

“…SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple signaling and disease related pathways with a broad diversity of reported…”
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Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture by Braam, Mitchell J. S., Zhao, Jia, Liang, Shenghui, Ida, Shogo, Kloostra, Nick K., Iworima, Diepiriye G., Tang, Mei, Baker, Robert K., Quiskamp, Nina, Piret, James M., Kieffer, Timothy J.

“…The generation of functional β-cells from human pluripotent stem cells (hPSCs) for cell replacement therapy and disease modeling of diabetes is being…”
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Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters by Zhao, Jia, Liang, Shenghui, Braam, Mitchell J S, Baker, Robert K, Iworima, Diepiriye G, Quiskamp, Nina, Kieffer, Timothy J

“…Differentiation of human pluripotent stem cells (hPSCs) into insulin-secreting beta cells provides material for investigating beta cell function and diabetes…”
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