Search Results - "Brüggemann, Roger"
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Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis
Published in Intensive care medicine (01-08-2021)“…Purpose Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive…”
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Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion
Published in Intensive care medicine (01-08-2020)“…Purpose Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of…”
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Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial
Published in JAMA : the journal of the American Medical Association (20-02-2018)“…IMPORTANCE: Results of studies on use of prophylactic haloperidol in critically ill adults are inconclusive, especially in patients at high risk of delirium…”
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Pharmacokinetics and Pharmacodynamics of Posaconazole
Published in Drugs (New York, N.Y.) (01-05-2020)“…Posaconazole is typically used for preventing invasive yeast and mold infections such as invasive aspergillosis in high-risk immunocompromised patients. The…”
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Cost Evaluation of Dried Blood Spot Home Sampling as Compared to Conventional Sampling for Therapeutic Drug Monitoring in Children
Published in PloS one (12-12-2016)“…Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in…”
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Aspergillus Test Profiles and Mortality in Critically Ill COVID-19 Patients
Published in Journal of clinical microbiology (18-11-2021)“…The literature regarding COVID-19-associated pulmonary aspergillosis (CAPA) has shown conflicting observations, including survival of CAPA patients not…”
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Drug‐drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4
Published in Transplant infectious disease (01-10-2017)“…Patients undergoing treatment with immunosuppressant drugs following solid organ or hematopoietic stem cell transplantation are at particular risk for…”
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Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents
Published in Clinical infectious diseases (15-05-2009)“…There are currently a number of licensed azole antifungal drugs; however; only 4 (namely, fluconazole, itraconazole, posaconazole, and voriconazole) are used…”
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Efficacy of Posaconazole against Three Clinical Aspergillus fumigatus Isolates with Mutations in the cyp51A Gene
Published in Antimicrobial Agents and Chemotherapy (01-02-2010)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance
Published in The Lancet infectious diseases (01-06-2021)“…Severe acute respiratory syndrome coronavirus 2 causes direct damage to the airway epithelium, enabling aspergillus invasion. Reports of COVID-19-associated…”
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Pharmacokinetics and Target Attainment of Antibiotics in Critically Ill Children: A Systematic Review of Current Literature
Published in Clinical pharmacokinetics (01-02-2020)“…Background Pharmacokinetics (PK) are severely altered in critically ill patients due to changes in volume of distribution (Vd) and/or drug clearance (Cl). This…”
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Prophylaxis Against Invasive Fungal Disease for Neutropenic Children and Young Adults
Published in JAMA : the journal of the American Medical Association (10-03-2020)Get full text
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Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters
Published in Expert opinion on drug metabolism & toxicology (04-03-2018)“…The rising prevalence of obesity confronts clinicians with dosing problems in the (extreme) overweight population. Obesity has a great impact on key organs…”
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High Variability in Isavuconazole Unbound Fraction in Clinical Practice: A Call to Reconsider Pharmacokinetic/Pharmacodynamic Targets and Breakpoints
Published in Clinical pharmacokinetics (01-12-2023)“…Isavuconazole exposure–response relationships have been studied with a focus on total rather than unbound exposure, assuming a constant unbound fraction of 1%…”
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Pharmacodynamics of isavuconazole in an Aspergillus fumigatus mouse infection model
Published in Antimicrobial agents and chemotherapy (01-05-2015)“…Azole resistance is an emerging problem in Aspergillus fumigatus which translates into treatment failure. Alternative treatments with new azoles may improve…”
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Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B
Published in Clinical infectious diseases (02-05-2019)“…Abstract Since its introduction in the 1990s, liposomal amphotericin B (LAmB) continues to be an important agent for the treatment of invasive fungal diseases…”
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Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study
Published in Pharmaceutical research (01-08-2019)“…Purpose Tobramycin is an aminoglycoside antibiotic of which the 24 h exposure correlates with efficacy. Recently, we found that clearance of the aminoglycoside…”
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International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus
Published in Drug resistance updates (01-07-2015)“…Abstract An international expert panel was convened to deliberate the management of azole-resistant aspergillosis. In culture-positive cases, in vitro…”
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Population Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies
Published in Clinical pharmacokinetics (01-12-2023)“…Background and Objectives Isavuconazole is a broad-spectrum antifungal agent for the management of invasive fungal disease. Optimised drug exposure is critical…”
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Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial
Published in Intensive care medicine (01-06-2021)“…Purpose Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant…”
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