Search Results - "Brügel, A."

From source terrains of the Eastern Alps to the Molasse Basin: Detrital record of non-steady-state exhumation by Kuhlemann, J., Dunkl, I., Brügel, A., Spiegel, C., Frisch, W.

“…Fission-track cooling ages of detrital apatite (AFT) in the East Alpine Molasse Basin display age groups corresponding to geodynamic events in the orogen since…”
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The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-α) production by Laughlin, Steven K., Clark, Michael P., Djung, Jane F., Golebiowski, Adam, Brugel, Todd A., Sabat, Mark, Bookland, Roger G., Laufersweiler, Matthew J., VanRens, John C., Townes, Jennifer A., De, Biswanath, Hsieh, Lily C., Xu, Susan C., Walter, Richard L., Mekel, Marlene J., Janusz, Michael J.

“…[Display omitted] 4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-α) inhibitors, which contain a novel isoxazolone…”
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Development of Orally Bioavailable Bicyclic Pyrazolones as Inhibitors of Tumor Necrosis Factor-α Production by Clark, Michael P, Laughlin, Steven K, Laufersweiler, Matthew J, Bookland, Roger G, Brugel, Todd A, Golebiowski, Adam, Sabat, Mark P, Townes, Jennifer A, VanRens, John C, Djung, Jane F, Natchus, Michael G, De, Biswanath, Hsieh, Lily C, Xu, Susan C, Walter, Rick L, Mekel, Marlene J, Heitmeyer, Sandra A, Brown, Kimberly K, Juergens, Karen, Taiwo, Yetunde O, Janusz, Michael J

“…2-Aryl-3-pyrimidinyl based tumor necrosis factor-α (TNF-α) inhibitors, which contain a novel bicyclic pyrazolone core, are described. Many showed low-nanomolar…”
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Intramolecular Diels−Alder Cyclizations of (E)-1-Nitro-1,7,9-decatrienes:  Synthesis of the AB Ring System of Norzoanthamine by Williams, David R, Brugel, Todd A

“…Cyclizations of substituted (E)-1-nitro-1,7,9-decatrienes under thermal and Lewis acid conditions have led to the formation of decalin ring systems with…”
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Investigations of Pd-Catalyzed Aryl Substitution Reactions. A Case Study towards Zoanthenol by R. Williams, David, C. Ihle, David, A. Brugel, Todd, Patnaik, Samarjit

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Nineteen polymorphic microsatellite markers from two African Vanilla species: across-species transferability and diversity in a wild population of V. humblotii from Mayotte by Gigant, R., Brugel, A., De Bruyn, A., Risterucci, A. M., Guiot, V., Viscardi, G., Humeau, L., Grisoni, M., Besse, P.

“…There is a serious lack of information on the genetic diversity and population dynamics of the 110 tropical Vanilla species, although these are keys elements…”
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Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1 by Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.

“…A series of isoquinuclidines and bicyclic analogs were investigated as inhibitors of glycine uptake for the treatment of schizophrenia. Dimethylbenzamide 9…”
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Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity by Peters, Matthew F., Zacco, Anna, Gordon, John, Maciag, Carla M., Litwin, Linda C., Thompson, Carolann, Schroeder, Patricia, Sygowski, Linda A., Piser, Timothy M., Brugel, Todd A.

“…The κ-opioid receptor plays a central role in mediating the response to stressful life events. Inhibiting κ-opioid receptor signaling is proposed as a…”
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N-Functionalization of Poly(ethylene glycol)-Linked Mono- and Bis-dioxocyclams as Potential Ligands for Gd3 by Brugel, Todd A, Hegedus, L. S

“…A number of highly functionalized dioxocyclams with acetic acid side chains on the secondary amine sites and ethylene glycol side chains on 6 and 13-positions…”
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The development of monocyclic pyrazolone based cytokine synthesis inhibitors by Golebiowski, Adam, Townes, Jennifer A., Laufersweiler, Matthew J., Brugel, Todd A., Clark, Michael P., Clark, Cynthia M., Djung, Jane F., Laughlin, Steven K., Sabat, Mark P., Bookland, Roger G., VanRens, John C., De, Biswanath, Hsieh, Lily C., Janusz, Michael J., Walter, Richard L., Webster, Mark E., Mekel, Marlene J.

“…[Display omitted] 4-Aryl-5-pyrimidyl based cytokine synthesis inhibitors that contain a novel monocyclic, pyrazolone heterocyclic core are described. Many of…”
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The development of novel inhibitors of tumor necrosis factor-α (TNF-α) production based on substituted [5,5]-bicyclic pyrazolones by Laufersweiler, Matthew J, Brugel, Todd A, Clark, Michael P, Golebiowski, Adam, Bookland, Roger G, Laughlin, Steven K, Sabat, Mark P, Townes, Jennifer A, VanRens, John C, De, Biswanath, Hsieh, Lily C, Heitmeyer, Sandra A, Juergens, Karen, Brown, Kimberly K, Mekel, Marlene J, Walter, Richard L, Janusz, Michael J

“…Graphic Novel substituted [5,5]-bicyclic pyrzazolones are presented as inhibitors of tumor necrosis factor-α (TNF-α) production. Many of these compounds show…”
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The development of new bicyclic pyrazole-based cytokine synthesis inhibitors by Townes, Jennifer A., Golebiowski, Adam, Clark, Michael P., Laufersweiler, Matthew J., Brugel, Todd A., Sabat, Mark, Bookland, Roger G., Laughlin, Steve K., VanRens, John C., De, Biswanath, Hsieh, Lily C., Xu, Susan C., Janusz, Michael J., Walter, Richard L.

“…4-Aryl-5-pyrimidyl-based cytokine synthesis inhibitors of TNF-α production, which contain a novel bicyclic pyrazole heterocyclic core, are described. Many of…”
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The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck) by Sabat, Mark, VanRens, John C., Laufersweiler, Matthew J., Brugel, Todd A., Maier, Jennifer, Golebiowski, Adam, De, Biswanath, Easwaran, Vijayasurian, Hsieh, Lily C., Walter, Richard L., Mekel, Marlene J., Evdokimov, Artem, Janusz, Michael J.

“…This communication details the synthesis, biological activity, and binding mode of a novel class of 2-benzimidazole substituted pyrimidines. The most potent…”
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4-Aryl piperazine and piperidine amides as novel mGluR5 positive allosteric modulators by Xiong, Hui, Brugel, Todd A., Balestra, Michael, Brown, Dean G., Brush, Kelly A., Hightower, Caprice, Hinkley, Lindsay, Hoesch, Valerie, Kang, James, Koether, Gerard M., McCauley, John P., McLaren, Francis M., Panko, Laura M., Simpson, Thomas R., Smith, Reed W., Woods, James M., Brockel, Becky, Chhajlani, Vijay, Gadient, Reto A., Spear, Nathan, Sygowski, Linda A., Zhang, Minli, Arora, Jalaj, Breysse, Nathalie, Wilson, Julie M., Isaac, Methvin, Slassi, Abdelmalik, King, Megan M.

“…Positive allosteric modulation of metabotropic glutamate receptor 5 (mGluR5) is regarded as a potential novel treatment for schizophrenic patients. Herein we…”
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SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2 by Brugel, Todd A., Smith, Reed W., Balestra, Michael, Becker, Christopher, Daniels, Thalia, Koether, Gerard M., Throner, Scott R., Panko, Laura M., Brown, Dean G., Liu, Ruifeng, Gordon, John, Peters, Matthew F.

“…Additional SAR for an extended set of structural modification to key moieties of a novel series of selective kappa opioid receptor antagonists based on a…”
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Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3) by Clark, Michael P., George, Kelly M., Bookland, Roger G., Chen, Jack, Laughlin, Steven K., Thakur, Kumar D., Lee, Wenlin, Davis, Jan R., Cabrera, Ed J., Brugel, Todd A., VanRens, John C., Laufersweiler, Matthew J., Maier, Jennifer A., Sabat, Mark P., Golebiowski, Adam, Easwaran, Vijay, Webster, Mark E., De, Biswanath, Zhang, George

“…A new class of bicyclic pyrrolopyrimidine-based Janus kinase 3 (JAK-3) inhibitors are described. Many of these inhibitors showed low nanomolar activity against…”
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Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1 by Brugel, Todd A., Smith, Reed W., Balestra, Michael, Becker, Christopher, Daniels, Thalia, Hoerter, Tiffany N., Koether, Gerard M., Throner, Scott R., Panko, Laura M., Folmer, James J., Cacciola, Joseph, Hunter, Angela M., Liu, Ruifeng, Edwards, Philip D., Brown, Dean G., Gordon, John, Ledonne, Norman C., Pietras, Mark, Schroeder, Patricia, Sygowski, Linda A., Hirata, Lee T., Zacco, Anna, Peters, Matthew F.

“…Discovery and SAR studies of a novel series of potent and selective kappa opioid receptor antagonists containing an 8-azabicylo[3.2.1]octane core is described…”
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Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1 by Varnes, Jeffrey G., Forst, Janet M., Hoerter, Tiffany N., Holmquist, Christopher R., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Wang, Xia, Potts, William M., Wood, Michael W., Alhambra, Cristóbal, Brugel, Todd A., Albert, Jeffrey S.

“…A series of novel GlyT1 inhibitors is described. A novel series of glycine transporter 1 (GlyT1) inhibitors is described. Scoping of the heterocycle moiety of…”
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The development of novel 1,2-dihydro-pyrimido[4,5- c]pyridazine based inhibitors of lymphocyte specific kinase (Lck) by Sabat, Mark, VanRens, John C., Brugel, Todd A., Maier, Jennifer, Laufersweiler, Matthew J., Golebiowski, Adam, De, Biswanath, Easwaran, Vijayasurian, Hsieh, Lily C., Rosegen, Jeff, Berberich, Steve, Suchanek, Eric, Janusz, Michael J.

“…This communication details the synthesis, biological activity, and proposed binding mode of a novel class of tri-cyclic derivatives of…”
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Development of N-4,6-pyrimidine- N-alkyl- N′-phenyl ureas as orally active inhibitors of lymphocyte specific tyrosine kinase by Maier, Jennifer A., Brugel, Todd A., Sabat, Mark, Golebiowski, Adam, Laufersweiler, Matthew J., VanRens, John C., Hopkins, Corey R., De, Biswanath, Hsieh, Lily C., Brown, Kimberly K., Easwaran, Vijayasurian, Janusz, Michael J.

“…A new class of lymphocyte specific tyrosine kinase (lck) inhibitors based on an N-4,6-pyrimidine- N-alkyl- N′-phenyl urea scaffold is described. A new class of…”
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