Search Results - "Brûlé, Sébastien"

Protein intrinsic viscosity determination with the Viscosizer TD instrument: reaching beyond the initially expected applications by Brûlé, Sébastien, Leroux, Raffaele, England, Patrick, Raynal, Bertrand

“…Intrinsic viscosity is a key hydrodynamic parameter to understand molecular structure and hydration, as well as intramolecular interactions. Commercially…”
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Fast and efficient purification of SARS-CoV-2 RNA dependent RNA polymerase complex expressed in Escherichia coli by Madru, Clément, Tekpinar, Ayten Dizkirici, Rosario, Sandrine, Czernecki, Dariusz, Brûlé, Sébastien, Sauguet, Ludovic, Delarue, Marc

“…To stop the COVID-19 pandemic due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which caused more than 2.5 million deaths to date, new…”
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Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress by Martinez, Mariano, Bouillon, Anthony, Brûlé, Sébastien, Raynal, Bertrand, Haouz, Ahmed, Alzari, Pedro M, Barale, Jean-Christophe

“…Malaria symptoms are associated with the asexual multiplication of within human red blood cells (RBCs) and fever peaks coincide with the egress of daughter…”
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Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases by Raia, Pierre, Carroni, Marta, Henry, Etienne, Pehau-Arnaudet, Gérard, Brûlé, Sébastien, Béguin, Pierre, Henneke, Ghislaine, Lindahl, Erik, Delarue, Marc, Sauguet, Ludovic

“…PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2)…”
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Biochemical characterization of the respiratory syncytial virus N 0 -P complex in solution by Esneau, Camille, Raynal, Bertrand, Roblin, Pierre, Brûlé, Sébastien, Richard, Charles-Adrien, Fix, Jenna, Eléouët, Jean-François, Galloux, Marie

“…As all the viruses belonging to the order, the nonsegmented negative-strand RNA genome of respiratory syncytial virus (RSV) is encapsidated by the viral…”
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMP dehydrogenases by Gedeon, Antoine, Ayoub, Nour, Brûlé, Sébastien, Raynal, Bertrand, Karimova, Gouzel, Gelin, Muriel, Mechaly, Ariel, Haouz, Ahmed, Labesse, Gilles, Munier‐Lehmann, Hélène

“…Inosine 5′‐monophosphate (IMP) dehydrogenase (IMPDH) is an ubiquitous enzyme that catalyzes the NAD+‐dependent oxidation of inosine 5′‐monophosphate into…”
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins by Zhu, Yanlei, Alvarez, Flavio, Wolff, Nicolas, Mechaly, Ariel, Brûlé, Sébastien, Neitthoffer, Benoit, Etienne-Manneville, Sandrine, Haouz, Ahmed, Boëda, Batiste, Caillet-Saguy, Célia

“…The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1)…”
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The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors by Balbino, Bianca, Herviou, Pauline, Godon, Ophélie, Stackowicz, Julien, Goff, Odile Richard-Le, Iannascoli, Bruno, Sterlin, Delphine, Brûlé, Sébastien, Millot, Gael A, Harris, Faith M, Voronina, Vera A, Nadeau, Kari C, Macdonald, Lynn E, Murphy, Andrew J, Bruhns, Pierre, Reber, Laurent L

“…Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of omalizumab is…”
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Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein by Gransagne, Marion, Aymé, Gabriel, Brier, Sébastien, Chauveau-Le Friec, Gaëlle, Meriaux, Véronique, Nowakowski, Mireille, Dejardin, François, Levallois, Sylvain, Dias de Melo, Guilherme, Donati, Flora, Prot, Matthieu, Brûlé, Sébastien, Raynal, Bertrand, Bellalou, Jacques, Goncalves, Pedro, Montagutelli, Xavier, Di Santo, James P., Lazarini, Françoise, England, Patrick, Petres, Stéphane, Escriou, Nicolas, Lafaye, Pierre

“…The current COVID-19 pandemic illustrates the importance of obtaining reliable methods for the rapid detection of SARS-CoV-2. A highly specific and sensitive…”
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An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins by Eshghi, Azad, Gaultney, Robert A., England, Patrick, Brûlé, Sébastien, Miras, Isabelle, Sato, Hiromi, Coburn, Jenifer, Bellalou, Jacques, Moriarty, Tara J., Haouz, Ahmed, Picardeau, Mathieu

“…Pathogenic Leptospira bacteria are the causative agents of leptospirosis, a zoonotic disease affecting animals and humans worldwide. These pathogenic species…”
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Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses by Demarta‐Gatsi, Claudia, Rivkin, Anna, Di Bartolo, Vincenzo, Peronet, Roger, Ding, Shuai, Commere, Pierre‐Henri, Guillonneau, François, Bellalou, Jacques, Brûlé, Sébastien, Abou Karam, Paula, Cohen, Sidney R., Lagache, Thibault, Janse, Chris J., Regev‐Rudzki, Neta, Mécheri, Salaheddine

“…Protozoan pathogens secrete nanosized particles called extracellular vesicles (EVs) to facilitate their survival and chronic infection. Here, we show the…”
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Dengue virus NS1 protein conveys pro‐inflammatory signals by docking onto high‐density lipoproteins by Benfrid, Souheyla, Park, Kyu‐Ho, Dellarole, Mariano, Voss, James E, Tamietti, Carole, Pehau‐Arnaudet, Gérard, Raynal, Bertrand, Brûlé, Sébastien, England, Patrick, Zhang, Xiaokang, Mikhailova, Anastassia, Hasan, Milena, Ungeheuer, Marie‐Noëlle, Petres, Stéphane, Biering, Scott B, Harris, Eva, Sakuntabhai, Anavaj, Buchy, Philippe, Duong, Veasna, Dussart, Philippe, Coulibaly, Fasséli, Bontems, François, Rey, Félix A, Flamand, Marie

“…The dengue virus nonstructural protein 1 (NS1) is a secreted virulence factor that modulates complement, activates immune cells and alters endothelial…”
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Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone by Tello Rubio, Bruno, Bugault, Florence, Baudon, Blandine, Raynal, Bertrand, Brûlé, Sébastien, Morel, Jean-David, Saint-Auret, Sarah, Blanchard, Nicolas, Demangel, Caroline, Guenin-Macé, Laure

“…Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of Buruli ulcer disease. Altough bacterially derived…”
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The anti‐FcεRI antibody MAR‐1 depletes basophils and cross‐reacts with myeloid cells through its Fc portion by Worrall, William P. M., Kamphuis, Jasper B. J., Stackowicz, Julien, Mougel, Aurélie, Mauré, Emilie, Pecalvel, Cyprien, Brûlé, Sébastien, Bruhns, Pierre, Guilleminault, Laurent, Reber, Laurent L.

“…In humans, the high-affinity IgE receptor FcεRI is expressed as a tetramer in mast cells (MCs) and basophils, and as a trimer in additional myeloid cell…”
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Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners by Zhu, Yanlei, Delhommel, Florent, Cordier, Florence, Lüchow, Susanne, Mechaly, Ariel, Colcombet-Cazenave, Baptiste, Girault, Virginie, Pepermans, Elise, Bahloul, Amel, Gautier, Candice, Brûlé, Sébastien, Raynal, Bertrand, Hoos, Sylviane, Haouz, Ahmed, Caillet-Saguy, Célia, Ivarsson, Ylva, Wolff, Nicolas

“…Hearing is a mechanical and neurochemical process, which occurs in the hair cells of inner ear that converts the sound vibrations into electrical signals…”
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The Pga59 cell wall protein is an amyloid forming protein involved in adhesion and biofilm establishment in the pathogenic yeast Candida albicans by Mourer, Thierry, El Ghalid, Mennat, Pehau-Arnaudet, Gérard, Kauffmann, Brice, Loquet, Antoine, Brûlé, Sébastien, Cabral, Vitor, d’Enfert, Christophe, Bachellier-Bassi, Sophie

“…The human commensal fungus Candida albicans can attach to epithelia or indwelling medical devices and form biofilms, that are highly tolerant to antifungal…”
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A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells by Voegele, Alexis, Sadi, Mirko, O'Brien, Darragh Patrick, Gehan, Pauline, Raoux‐Barbot, Dorothée, Davi, Maryline, Hoos, Sylviane, Brûlé, Sébastien, Raynal, Bertrand, Weber, Patrick, Mechaly, Ariel, Haouz, Ahmed, Rodriguez, Nicolas, Vachette, Patrice, Durand, Dominique, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre

“…The molecular mechanisms and forces involved in the translocation of bacterial toxins into host cells are still a matter of intense research. The adenylate…”
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The Immunomodulatory Effect of IrSPI, a Tick Salivary Gland Serine Protease Inhibitor Involved in Ixodes ricinus Tick Feeding by Blisnick, Adrien A, Šimo, Ladislav, Grillon, Catherine, Fasani, Fabienne, Brûlé, Sébastien, Le Bonniec, Bernard, Prina, Eric, Marsot, Maud, Relmy, Anthony, Blaise-Boisseau, Sandra, Richardson, Jennifer, Bonnet, Sarah I

“…Ticks are the most important vectors of pathogens affecting both domestic and wild animals worldwide. Hard tick feeding is a slow process-taking up to several…”
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs by Gedeon, Antoine, Ayoub, Nour, Brûlé, Sébastien, Raynal, Bertrand, Karimova, Gouzel, Gelin, Muriel, Mechaly, Ariel, Haouz, Ahmed, Labesse, Gilles, Munier-Lehmann, Hélène

“…Inosine 5'-monophosphate dehydrogenase (IMPDH) is a^ ubiquitous enzyme that catalyzes the NAD+ -dependent oxidation of inosine 5'-monophosphate into xanthosine…”
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CyaA toxin translocation across host cell plasma membrane requires hijacking of calmodulin by Voegele, Alexis, Sadi, Mirko, O'Brien, Darragh P., Gehan, Pauline, Hoos, Sylviane, Brûlé, Sébastien, Raynal, Bertrand, Mechaly, Ariel, Haouz, Ahmed, Rodriguez, Nicolas, Vachette, Patrice, Durand, Dominique, Brier, Sébastien, Ladant, Daniel, Chenal, Alexandre

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