Search Results - "Bräuner‐Osborne, H"

The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function by Clemmensen, C, Smajilovic, S, Wellendorph, P, Bräuner‐Osborne, H

“…GPRC6A (GPCR, class C, group 6, subtype A) is a class C GPCR that has been cloned from human, mouse and rat. Several groups have shown that the receptor is…”
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Molecular basis for amino acid sensing by family C G‐protein‐coupled receptors by Wellendorph, P, Bräuner‐Osborne, H

“…Family C of human G‐protein‐coupled receptors (GPCRs) is constituted by eight metabotropic glutamate receptors, two γ‐aminobutyric acid type B (GABAB1–2)…”
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Pharmacological characterization of mouse GPRC6A, an L‐α‐amino‐acid receptor modulated by divalent cations by Christiansen, B, Hansen, K B, Wellendorph, P, Bräuner‐Osborne, H

“…Background and purpose: GPRC6A is a novel member of family C of G protein‐coupled receptors with so far unknown function. We have recently described both human…”
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The orthosteric GABAA receptor ligand Thio‐4‐PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors by Hoestgaard‐Jensen, K, O'Connor, R M, Dalby, N O, Simonsen, C, Finger, B C, Golubeva, A, Hammer, H, Bergmann, M L, Kristiansen, U, Krogsgaard‐Larsen, P, Bräuner‐Osborne, H, Ebert, B, Frølund, B, Cryan, J F, Jensen, A A

“…Background and Purpose Explorations into the heterogeneous population of native GABA type A receptors (GABAARs) and the physiological functions governed by the…”
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Different domains of the glucagon and glucagon‐like peptide‐1 receptors provide the critical determinants of ligand selectivity by Runge, S, Wulff, B S, Madsen, K, Bräuner‐Osborne, H, Knudsen, L B

“…Glucagon and glucagon‐like peptide‐1 (GLP‐1) are homologous peptide hormones with important functions in glucose metabolism. The receptors for glucagon and…”
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1,2,3-Triazolyl amino acids as AMPA receptor ligands by Stanley, N.J., Pedersen, D. Sejer, Nielsen, B., Kvist, T., Mathiesen, J.M., Bräuner-Osborne, H., Taylor, D.K., Abell, A.D.

“…The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and…”
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Ligands for Glutamate Receptors:  Design and Therapeutic Prospects by Bräuner-Osborne, Hans, Egebjerg, Jan, Nielsen, Elsebet Ø, Madsen, Ulf, Krogsgaard-Larsen, Povl

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Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors by Madsen, Ulf, Bräuner-Osborne, Hans, Frydenvang, Karla, Hvene, Lise, Johansen, Tommy N, Nielsen, Birgitte, Sánchez, Connie, Stensbøl, Tine B, Bischoff, Francois, Krogsgaard-Larsen, Povl

“…Using ibotenic acid (2) as a lead, two series of 3-isoxazolol amino acid ligands for (S)-glutamic acid (Glu, 1) receptors have been developed. Whereas…”
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Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure by Krogsgaard-Larsen, P, Ebert, B, Lund, TM, Bräuner-Osborne, H, Sløk, FA, Johansen, TN, Brehm, L, Madsen, U

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Sequence and Expression Pattern of a Novel Human Orphan G-Protein-Coupled Receptor, GPRC5B, a Family C Receptor with a Short Amino-Terminal Domain by Bräuner-Osborne, Hans, Krogsgaard-Larsen, Povl

“…Query of GenBank with the amino acid sequence of human metabotropic glutamate receptor subtype 2 (mGluR2) identified a predicted gene product of unknown…”
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Pharmacology of (S)‐homoquisqualic acid and (S)‐2‐amino‐5‐phosphonopentanoic acid [(S)‐AP5] at cloned metabotropic glutamate receptors by Bräuner‐Osborne, Hans, Krogsgaard‐Larsen, Povl

“…In this study we have determined the pharmacological profile of (S)‐quisqualic acid, (S)‐2‐amino‐4‐phosphonobutyric acid ((S)‐AP4) and their higher homologues…”
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview by Alexander, Stephen PH, Kelly, Eamonn, Marrion, Neil V, Peters, John A, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Buneman, O Peter, Cidlowski, John A, Christopoulos, Arthur, Davenport, Anthony P, Abbracchio, M‐P, Aldrich, R, Attali, B, Bäck, M, Bathgate, R, Bettler, B, Biel, M, Birdsall, NJ, Boison, D, Bräuner‐osborne, H, Bröer, S, Burnstock, G, Calo, G, Catterall, WA, Chan, SL, Chazot, P, Chiang, N, Chung, J‐J, Clapham, DE, Clapp, L, Connor, MA, Davies, P, Dawson, PA, Dent, G, Fong, TM, Fowler, CJ, Frantz, A, Fuller, P, Gershengorn, MA, Goldstein, SAN, Goudet, C, Hammond, JR, Hancox, JC, Hanson, J, Hanukoglu, I, Hollenberg, AN, Holliday, ND, Hoyer, D, Inui, KI, Irving, AJ, Ishii, S, Jacobson, KA, Jensen, R, Jockers, R, Karnik, S, Kellenberger, S, Kennedy, C, Kerr, ID, Kihara, Y, Larhammar, D, Leach, K, Lecca, D, Leprince, J, Macewan, D, Maguire, JJ, Marshall, F, Mazella, J, Mcardle, CA, Mitolo, V, Mizuno, H, Mouillac, B, Panaro, MA, Perez‐reyes, E, Pertwee, RG, Pisegna, JR, Plant, LD, Poyner, DR, Pyne, S, Ramachandran, R, Ren, D, Sanger, G, Sanguinetti, MC, Schulte, G, Schulz, S, Segaloff, DL, Singh, KD, Slesinger, PA, Sobey, CG, Stoddart, LA, Thwaites, D, Toll, L, Trimmer, JS, Vaudry, H, Vilargada, J‐P, Wei, AD, Woodruff, TM, Ye, RD, Zajac, J‐M

“…The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties…”
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The Concise Guide to PHARMACOLOGY 2015/16: Overview by Alexander, Stephen PH, Kelly, Eamonn, Marrion, Neil, Peters, John A, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Catterall, William A, Cidlowski, John A, Davenport, Anthony P, Fabbro, Doriano, Fan, Grace, Davies, Jamie A, Aldrich, R, Attali, B, Bäck, Ml, Bathgate, R, Birdsall, NJ, Bryant, C, Burris, T, Calo, G, Chan, SL, Chandy, KG, Christopoulos, A, Chung, J‐J, Clapham, DE, Coons, L, Dautzenberg, FM, Dent, G, Douglas, SD, Dubocovich, ML, Farndale, R, Fowler, CJ, Gainetdinov, RR, Gershengorn, MA, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hay, DL, Hoyer, D, Inui, KI, Ishii, S, Jan, LY, Jensen, R, Jetten, A, Jockers, R, Kanai, Y, Kang, HS, Karnik, S, Kerr, ID, Larhammar, D, Lolait, SJ, Macewan, D, Maguire, JJ, May, JM, Mazella, J, Mcardle, CA, Mcdonnell, DP, Miller, LJ, Mitolo, V, Monk, PN, Murphy, PM, Norel, X, Oakley, R, Palmer, LG, Panaro, MA, Pertwee, RG, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Prossnitz, ER, Pyne, S, Rondard, P, Sackin, H, Safi, R, Sanguinetti, MC, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Toll, L, Trimmer, JS, Tsai, M‐J, Tsai, SY, Usdin, TB, Vilargada, J‐P, Vore, M, Ward, DT, Wei, AD, Willars, GB, Winrow, C, Wulff, H, Young, M, Zajac, J‐M

“…The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links…”
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Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis by Spalding, T A, Burstein, E S, Brauner-Osborne, H, Hill-Eubanks, D, Brann, M R

“…We have isolated a mutant m5 muscarinic receptor that mediates robust functional responses in the absence of agonists. This constitutively active receptor was…”
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3-Pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing by Zimmermann, Diane, Janin, Yves Louis, Brehm, Lotte, Bräuner-Osborne, Hans, Ebert, Bjarke, Johansen, Tommy Nørskov, Madsen, Ulf, Krogsgaard-Larsen, Povl

“…We have previously shown that the higher homologue of ( S)-glutamic acid [( S)-Glu], ( S)-α-aminoadipic acid [( S)-α-AA] is selectively recognized by the mGlu…”
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Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors by Bräuner-Osborne, Hans, Nielsen, Birgitte, Stensbøl, Tine B, Johansen, Tommy N, Skjærbæk, Niels, Krogsgaard-Larsen, Povl

“…The pharmacology of (2 S,4 R)-4-methylglutamic acid, (2 S,4 S)-4-methylglutamic acid and ( S)- and ( R)-4-methyleneglutamic acids (obtained in high chemical…”
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The Agonist-binding Domain of the Calcium-sensing Receptor Is Located at the Amino-terminal Domain by Bräuner-Osborne, Hans, Jensen, Anders A., Sheppard, Paul O., O'Hara, Patrick, Krogsgaard-Larsen, Povl

“…The calcium-sensing receptor (CaR) is a G-protein-coupled receptor that displays 19–25% sequence identity to the γ-aminobutyric acid type B (GABA B ) and…”
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Agonists and Inverse Agonists for the Herpesvirus 8-encoded Constitutively Active Seven-transmembrane Oncogene Product, ORF-74 by Rosenkilde, Mette M., Kledal, Thomas N., Bräuner-Osborne, Hans, Schwartz, Thue W.

“…A number of CXC chemokines competed with similar, nanomolar affinity against 125I-interleukin-8 (IL-8) binding to ORF-74, a constitutively active…”
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Synthesis and Pharmacology of a New AMPA−Kainate Receptor Agonist with Potent Convulsant Activity by Conti, Paola, De Amici, Marco, De Sarro, Giovambattista, Stensbøl, Tine Bryan, Bräuner-Osborne, Hans, Madsen, Ulf, De Micheli, Carlo

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Functional partial agonism at cloned human muscarinic acetylcholine receptors by Bräuner-Osborne, Hans, Ebert, Bjarke, Brann, Mark R., Falch, Erik, Krogsgaard-Larsen, Povl

“…We have previously defined the concept of functional partial agonism as the partial agonist responses recorded in brain slices after administration of full…”
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