Search Results - "Brändli, André W."

Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus by Wheeler, Grant N., Brändli, André W.

“…Chemical genetics uses small molecules to modulate protein function and, in principle, has the potential to perturb any biochemical event in a complex cellular…”
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WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors by Motamedi, Fariba Jian, Badro, Danielle A., Clarkson, Michael, Rita Lecca, M, Bradford, Stephen T., Buske, Fabian A., Saar, Kathrin, Hübner, Norbert, Brändli, André W., Schedl, Andreas

“…Kidney organogenesis requires the tight control of proliferation, differentiation and apoptosis of renal progenitor cells. How the balance between these…”
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miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo by Leslie Pedrioli, Deena M., Karpanen, Terhi, Dabouras, Vasilios, Jurisic, Giorgia, van de Hoek, Glenn, Shin, Jay W., Marino, Daniela, Kälin, Roland E., Leidel, Sebastian, Cinelli, Paolo, Schulte-Merker, Stefan, Brändli, André W., Detmar, Michael

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy by Dietzel, Steffen, Pircher, Joachim, Nekolla, A Katharina, Gull, Mazhar, Brändli, André W, Pohl, Ulrich, Rehberg, Markus

“…Determination of blood flow velocity and related hemodynamic parameters is an important aspect of physiological studies which in many settings requires…”
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Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis by Kälin, Roland E., Kretz, Martin P., Meyer, Andrea M., Kispert, Andreas, Heppner, Frank L., Brändli, André W.

“…Apelin and its G protein-coupled receptor APJ play important roles in blood pressure regulation, body fluid homeostasis, and possibly the modulation of immune…”
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Functional genetic targeting of embryonic kidney progenitor cells ex vivo by Junttila, Sanna, Saarela, Ulla, Halt, Kimmo, Manninen, Aki, Pärssinen, Heikki, Lecca, M Rita, Brändli, André W, Sims-Lucas, Sunder, Skovorodkin, Ilya, Vainio, Seppo J

“…The embryonic mammalian metanephric mesenchyme (MM) is a unique tissue because it is competent to generate the nephrons in response to Wnt signaling. An ex…”
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Organization of the pronephric kidney revealed by large-scale gene expression mapping by Raciti, Daniela, Reggiani, Luca, Geffers, Lars, Jiang, Qiuhong, Bacchion, Francesca, Subrizi, Astrid E, Clements, Dave, Tindal, Christopher, Davidson, Duncan R, Kaissling, Brigitte, Brändli, André W

“…The pronephros, the simplest form of a vertebrate excretory organ, has recently become an important model of vertebrate kidney organogenesis. Here, we…”
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The prepattern transcription factor Irx3 directs nephron segment identity by Reggiani, Luca, Raciti, Daniela, Airik, Rannar, Kispert, Andreas, Brändli, André W

“…The nephron, the basic structural and functional unit of the vertebrate kidney, is organized into discrete segments, which are composed of distinct renal…”
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An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis by Kälin, Roland E., Bänziger-Tobler, Nadja E., Detmar, Michael, Brändli, André W.

“…Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor…”
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Genome-wide gene expression profiling reveals renal genes regulated during metabolic acidosis by Nowik, Marta, Lecca, M. Rita, Velic, Ana, Rehrauer, Hubert, Brandli, Andre W, Wagner, Carsten A

“…1 Institute of Physiology and Zurich Center for Human Integrative Physiology (ZIHP), University of Zurich 2 Institute of Pharmaceutical Sciences, Department of…”
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The FGFRL1 Receptor Is Shed from Cell Membranes, Binds Fibroblast Growth Factors (FGFs), and Antagonizes FGF Signaling in Xenopus Embryos by Steinberg, Florian, Zhuang, Lei, Beyeler, Michael, Kälin, Roland E., Mullis, Primus E., Brändli, André W., Trueb, Beat

“…FGFRL1 (fibroblast growth factor receptor like 1) is the fifth and most recently discovered member of the fibroblast growth factor receptor (FGFR) family. With…”
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A role for all-trans-retinoic acid in the early steps of lymphatic vasculature development by Marino, Daniela, Dabouras, Vasilios, Brändli, André W, Detmar, Michael

“…The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence…”
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Chemical Screening and Toxicity Testing by Brändli, André W

“…The chemical space is vast, encompassing potentially billions of natural and synthetic molecules, which are for the most part uncharted with regard to their…”
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Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis by Maurus, Daniel, Héligon, Christophe, Bürger-Schwärzler, Anja, Brändli, André W, Kühl, Michael

“…Wnt‐4 is expressed in developing neural and renal tissue and is required for renal tubulogenesis in mouse and Xenopus. The function of Wnt‐4 in neural…”
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Heat-shock mediated overexpression of HNF1β mutations has differential effects on gene expression in the Xenopus pronephric kidney by Sauert, Kathrin, Kahnert, Stefan, Roose, Magdalena, Gull, Mazhar, Brändli, André W, Ryffel, Gerhart U, Waldner, Christoph

“…The transcription factor HNF1B, encoded by the TCF2 gene, plays an important role in the organogenesis of vertebrates. In humans, heterozygous mutations of…”
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Screening of Chemical Libraries Using Xenopus Embryos and Tadpoles for Phenotypic Drug Discovery by Gull, Mazhar, Schmitt, Stefan M, Kälin, Roland E, Brändli, André W

“…Phenotypic drug discovery assesses the effect of small molecules on the phenotype of cells, tissues, or whole organisms without a priori knowledge of the…”
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Functional characterization of two 20β-hydroxysteroid dehydrogenase type 2 homeologs from Xenopus laevis reveals multispecificity by Tokarz, Janina, Schmitt, Stefan M., Möller, Gabriele, Brändli, André W., Adamski, Jerzy

“…•Identification of amphibian 20β-HSD type 2 enzymes.•Cortisone is not a physiological substrate for X. laevis 20β-HSD type 2 enzymes.•Substrate…”
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Engineering Xenopus embryos for phenotypic drug discovery screening by Schmitt, Stefan M., Gull, Mazhar, Brändli, André W.

“…Many rare human inherited diseases remain untreatable despite the fact that the disease causing genes are known and adequate mouse disease models have been…”
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Gene expression analysis defines the proximal tubule as the compartment for endocytic receptor-mediated uptake in the Xenopus pronephric kidney by Christensen, Erik I., Raciti, Daniela, Reggiani, Luca, Verroust, Pierre J., Brändli, André W.

“…Endocytic receptors in the proximal tubule of the mammalian kidney are responsible for the reuptake of numerous ligands, including lipoproteins, sterols,…”
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Encoding chemistry by Neri, Dario, Brändli, André W

“…A new methodology combining small molecules and phage-displayed peptides enables the isolation of chemically modified bicyclic peptides capable of…”
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